Abstract

One aspect of the present disclosure relates to a compound including a photosensitizer and an imidazopyridine derivative, a liposome including the compound, and a photodynamic therapeutic composition containing the compound or the liposome. According to exemplary embodiments of the present invention, a photosensitizer and an imidazopyridine derivative that can specifically target TSPO are contained to enhance the targeting capability, leading to high binding affinity for biomarkers. In addition, liposomes are utilized not only to prevent unwanted effects on other organs in the body, but also to selectively target tumors, thereby enabling very safe photodynamic therapy. In addition, according to exemplary embodiments of the present invention, a photodynamic therapeutic composition can be provided that can be effectively used in cancer treatment as a substitute for existing anticancer drugs.

IPC Classes  ?

• A61K 47/54 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
• A61K 9/127 - Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
• A61K 41/00 - Medicinal preparations obtained by treating materials with wave energy or particle radiation
• A61K 51/04 - Organic compounds
• A61P 35/00 - Antineoplastic agents

Abstract

The present invention relates to a novel microorganism and a use thereof for preventing, alleviating, or treating intestinal diseases. The strain according to one embodiment has effects of inhibiting intestinal atrophy and reducing bloody stools, and thus is useful for the prevention, amelioration, or treatment of intestinal diseases. In addition, since the strain is significantly reduced in the patient group, the strain can be used for early diagnosis of intestinal diseases or selection of a risk group.

IPC Classes  ?

• C12N 1/20 - BacteriaCulture media therefor
• A61K 35/742 - Spore-forming bacteria, e.g. Bacillus coagulans, Bacillus subtilis, clostridium or Lactobacillus sporogenes
• A61P 1/00 - Drugs for disorders of the alimentary tract or the digestive system
• C12R 1/145 - Clostridium

Abstract

The present invention relates to an apparatus and a method for generating a dental examination result report, which are capable of simply creating an examination result and automatically generating, on the basis of the created examination result, a dental examination result report to be provided to an examinee, the apparatus comprising: a dental examination opinion input template DB for storing a dental examination opinion input template standardized for each dental examination item; a dental examination opinion input unit for receiving an examination opinion related to a dental examination through the dental examination opinion input template; a dental examination result report generation unit which generates a dental examination result report on the basis of the received examination opinion, and which generates, on the basis of the received examination opinion, a dental examination result report including a dental arch image in which a dental examination result of the examinee is visually displayed; and a dental examination result report provision unit for providing, through a standardized result report template, the dental examination result report generated by the dental examination result report generation unit.

IPC Classes  ?

• G16H 15/00 - ICT specially adapted for medical reports, e.g. generation or transmission thereof
• G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
• G06F 3/048 - Interaction techniques based on graphical user interfaces [GUI]
• G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
• G16H 50/50 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
• G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
• A61B 6/51 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body partsApparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific clinical applications for dentistry
• G16H 20/30 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to physical therapies or activities, e.g. physiotherapy, acupressure or exercising
• G06N 3/0464 - Convolutional networks [CNN, ConvNet]
• G06N 3/044 - Recurrent networks, e.g. Hopfield networks

Abstract

Disclosed are an apparatus and a method for determining whether a target heart has returned to spontaneous circulation according to an embodiment. The apparatus for determining whether a target heart has returned to spontaneous circulation according to an embodiment comprises: one or more processors; and one or more memories storing instructions executed by the one or more processors. The one or more processors: determine the opened/closed state of a valve within the target heart on the basis of first bio-signal generated in response to the physical activity of the target heart; and determine whether the target heart has returned to spontaneous circulation on the basis of the opened/closed state of the valve.

IPC Classes  ?

• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 5/11 - Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb
• A61B 5/318 - Heart-related electrical modalities, e.g. electrocardiography [ECG]

Abstract

The present invention relates to a system, a device, and a method for providing medical examination information and feedback by utilizing image processing and artificial intelligence technology. The method may comprise the steps of: acquiring a medical image by photographing a part of the body of a subject to be examined by a medical examination device; extracting, from the medical image, medical information including first information related to usability of the medical examination device and second information related to a standardized examination index; identifying whether the medical information satisfies a specified rule; and providing feedback information notifying that the rule fails to be satisfied when at least a part of the medical information fails to satisfy the rule. The present invention can improve usability (or performance capability) of a medical examination device (e.g., endoscope) and/or a quality of a medical examination (e.g., the accuracy and/or efficiency of diagnosis). In addition, the present invention can improve the accuracy and/or completeness of an interpretation.

IPC Classes  ?

• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
• G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
• G16H 30/20 - ICT specially adapted for the handling or processing of medical images for handling medical images, e.g. DICOM, HL7 or PACS
• G16H 70/20 - ICT specially adapted for the handling or processing of medical references relating to practices or guidelines
• G16H 40/60 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices
• G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
• G06N 3/0464 - Convolutional networks [CNN, ConvNet]
• G06N 3/045 - Combinations of networks
• G06T 7/00 - Image analysis

Abstract

The present invention provides a two-fluid nozzle for supplying a medicinal fluid and gas into the abdominal cavity. A two-fluid nozzle, according to one embodiment, may comprise: a first nozzle cap having a mixing space in which a medicinal fluid and gas are mixed, and having an injection hole formed therein through which the mixed fluid is injected; a second nozzle cap having an internal space and coupled to the first nozzle cap; and a nozzle part disposed in the internal space, wherein the nozzle part may have a medicinal fluid flow space, in which the medicinal fluid flows, at the central portion thereof, and a gas flow space, in which the gas flows, at the peripheral portion thereof surrounding the central portion, and the first nozzle cap may be formed in a dome shape.

IPC Classes  ?

• A61M 13/00 - Insufflators for therapeutic or disinfectant purposes
• A61M 31/00 - Devices for introducing or retaining media, e.g. remedies, in cavities of the body
• A61M 11/02 - Sprayers or atomisers specially adapted for therapeutic purposes operated by air pressure applied to the liquid to be sprayed or atomised
• A61M 3/02 - EnemataIrrigators

Abstract

One aspect of the present disclosure relates to a method for providing motor impairment-related information, comprising the steps of: (a) measuring a brain network index according to movement performance of an affected side part of a subject; and (b) comparing the brain network index measured in step (a) with a brain network index according to movement performance of an unaffected side part of the subject. In addition, another aspect of the present disclosure relates to a device for providing a motor impairment-related information that provides a brain network index obtained according to movement performance of a subject. The method or device for providing motor impairment-related information of the present invention according to the present disclosure has an excellent effect of providing information on prognosis for motor impairment, motor impairment-related diagnosis, or motor impairment-related rehabilitation.

IPC Classes  ?

• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 5/291 - Bioelectric electrodes therefor specially adapted for particular uses for electroencephalography [EEG]
• A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers
• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems

Abstract

The present invention provides a system for maintaining the temperature of a patient. The temperature maintenance system according to an embodiment comprises: a first temperature maintenance unit that directly delivers a first heat source to an exposed part of a patient; and an air supply unit that supplies air to block the first heat source emitted from the first temperature maintenance unit, from being discharged from the exposed part, wherein the first temperature maintenance unit may not be in contact with both the exposed part and the patient's body.

IPC Classes  ?

• A61N 5/06 - Radiation therapy using light
• A61F 7/00 - Heating or cooling appliances for medical or therapeutic treatment of the human body

Abstract

The embodiments relate to a smart terminal for acquiring medical information related to electrocardiographic auditory aspects, the smart terminal having: one or more processors; and a memory for storing instructions executed by the one or more processors, the instructions, when executed by the one or more processors, enabling the one or more processors to acquire sounds of the body of a subject by means of at least one audio unit connected to a body of the smart terminal, and acquire an electrocardiogram of the body of the subject by means of a plurality of electrocardiogram units included in the smart terminal, wherein a portion of the electrocardiogram units, among the plurality of electrocardiogram units, and the at least one audio unit form a unit array disposed toward a body part of the subject.

IPC Classes  ?

• A61B 5/346 - Analysis of electrocardiograms
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 7/00 - Instruments for auscultation
• A61B 7/04 - Electric stethoscopes
• A61B 8/00 - Diagnosis using ultrasonic, sonic or infrasonic waves
• G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems

Abstract

The disclosure features compositions and methods for the treatment of sensorineural hearing loss and auditory neuropathy, particularly forms of the disease that are associated with biallelic missense mutations in otoferlin (OTOE), by way of OTOE gene therapy. The disclosure provides a variety of compositions that include a first nucleic acid vector that contains a polynucleotide encoding an N-terminal portion of an OTOE isoform 5 protein and a second nucleic acid vector that contains a polynucleotide encoding a C-terminal portion of an OTOE isoform 5 protein. These vectors can be used to increase the expression of OTOE in a subject, such as a human subject suffering from sensorineural hearing loss.

IPC Classes  ?

• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
• C07K 14/47 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from mammals
• C12N 15/864 - Parvoviral vectors
• A61P 27/16 - Otologicals

Abstract

The present invention relates to: a sonosensitizer composition that does not exhibit phototoxicity, the sonosensitizer composition comprising a phthalocyanine compound with paramagnetic ions bonded thereto, or a pharmaceutically acceptable salt thereof; and a use thereof. According to an aspect, a sonosensitizer composition comprising a phthalocyanine compound with paramagnetic ions of copper (II) or nickel (II) bonded thereto or a pharmaceutically acceptable salt thereof can effectively kill cancer cells, by exhibiting excellent ROS generation activity when exposed to ultrasound, without exhibiting phototoxicity, which is one of the side effects of conventional photosensitizers. In addition, the sonosensitizer composition has sonodynamic properties, improved tumor specificity, and excellent biocompatibility, and thus can be effectively used as an anticancer agent. Meanwhile, the present invention was achieved with the support of the following in-hospital research project under the supervision of Seoul National University Bundang Hospital. [In-Hospital Research Project Supporting Present Invention] [MSRI Project Number] 13-2021-0003 [Specialized Research Management Agency] Seoul National University Bundang Hospital [Project Name] Development of tumor-targeting high-sensitivity ultrasound-responsive agent using focused ultrasound equipment and research on immunomodulatory mechanism [Contribution Rate] 50% [Main Organization] Seoul National University Bundang Hospital [Research Period] 01 March 2021 - 31 August 2024

IPC Classes  ?

• A61K 41/00 - Medicinal preparations obtained by treating materials with wave energy or particle radiation
• A61K 31/555 - Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
• A61P 35/00 - Antineoplastic agents

Abstract

The present invention provides a nozzle unit for supplying medicinal liquid and gas into the abdominal cavity. The nozzle unit according to one embodiment may comprise: a nozzle for discharging the medicinal liquid; a nozzle cap coupled to the nozzle to form a mixing space therein in which the medicinal liquid and the gas are mixed, and having a spray hole formed in the lower part thereof for spraying a fluid in which the medicinal liquid and the gas are mixed; a first conduit inserted into the nozzle for transferring the medicinal liquid to the nozzle; and a second conduit surrounding the first conduit and inserted into the nozzle cap for transferring the gas to the mixing space, wherein a space formed between the first conduit and the second conduit may be in fluid communication with the mixing space.

IPC Classes  ?

• A61M 13/00 - Insufflators for therapeutic or disinfectant purposes
• A61M 11/02 - Sprayers or atomisers specially adapted for therapeutic purposes operated by air pressure applied to the liquid to be sprayed or atomised
• A61M 31/00 - Devices for introducing or retaining media, e.g. remedies, in cavities of the body
• A61M 3/02 - EnemataIrrigators
• A61M 25/00 - CathetersHollow probes

Abstract

Embodiments relate to a smart terminal for acquiring medical information including an auditory aspects, comprising one or more processors and a memory for storing instructions executed by the one or more processors, wherein the instructions, when executed by the one or more processors, allow the one or more processors to cause: at least one acoustic unit connected to the body of the smart terminal to acquire body sound of a subject; a data processing module included in the smart terminal to process, in a preset data format, raw body information about body sound and/or a body electrocardiogram, so as to generate medical information about the subject; and a pressure switch included in the smart terminal to generate an electrical signal when switched by the pressure applied thereto.

IPC Classes  ?

• A61B 5/346 - Analysis of electrocardiograms
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons

Abstract

KCNB2GHSRNOS2CAPN10FASNKCNH6DIS3L2NR0B2NR0B2(Nuclear Receptor Subfamily 0 Group B Member 2).

IPC Classes  ?

• C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material

Abstract

The present invention relates to an artificial intelligence-based device and method for determining amyloid PET positivity, wherein a normal-appearing white matter dominance ratio is used and amyloid PET positivity is automatically determined based on machine learning, thereby improving the accuracy and sensitivity of amyloid PET positivity determination. The device comprises: an image acquisition unit for acquiring PET and MRI images of the brain of a diagnostic subject administered with a contrast agent, the images being acquired through tomographic scanning; a segmentation unit for segmenting normal-appearing white matter (NAWM) and white matter hyperintensity (WMH) from a fluid attenuated inversion recovery (FLAIR) image obtained from the MRI image; a standardized uptake value ratio (SUVR) calculation unit for calculating a global standardized uptake value ratio (SUVR) and a standardized uptake value ratio in normal-appearing white matter (NAWM SUVR), on the basis of the PET image and the NAWM region segmented by the segmentation unit; and an amyloid PET positivity determination unit for determining amyloid PET positivity by inputting the global SUVR and the NAWM dominance ratio (NDR) into a pre-trained prediction model, wherein the NDR is a value obtained by dividing the global SUVR by the NAWM SUVR.

IPC Classes  ?

• A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
• A61B 6/03 - Computed tomography [CT]
• A61B 6/50 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body partsApparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific clinical applications
• A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems

Abstract

The present invention relates to a lung mimicking microphysiological system including a porous membrane including lung organoids or lung organoid-derived transitional differentiated cells, macrophages, and vascular endothelial cells; and a manufacturing method thereof. More specifically, the system of the present invention has high utility as a lung immune response-mimetic air-fluid interface microphysiological system. The system of the present invention can be exposed to an external infectious agent or a drug under the same conditions as the lung in vivo, thus can conduct a wide range of research, including modeling of lung immune responses by external infectious agents and a test for therapeutic drug efficacy according to lung infectious agents, and further can also be utilized in in vitro toxicity evaluation, disease modeling, new drug development, precision medicine, and the like.

IPC Classes  ?

• C12M 3/00 - Tissue, human, animal or plant cell, or virus culture apparatus
• C12M 1/00 - Apparatus for enzymology or microbiology
• C12M 1/12 - Apparatus for enzymology or microbiology with sterilisation, filtration, or dialysis means
• C12N 5/071 - Vertebrate cells or tissues, e.g. human cells or tissues

Abstract

Disclosed herein is a pharmaceutical composition for preventing or treating endometriosis, comprising fraxetin. When used as a pharmaceutical composition for preventing or treating endometriosis and complications associated therewith, with fraxetin or a pharmaceutically acceptable salt thereof as an active ingredient, the present disclosure offers effective management of endometriosis with fewer side effects compared to surgery and hormone therapy and thus can be advantageously used as a therapeutic agent for endometriosis and complications associated therewith.

IPC Classes  ?

• A61K 31/37 - Coumarins, e.g. psoralen
• A61K 31/145 - Amines, e.g. amantadine having sulfur atoms, e.g. thiurams (N—C(S)—S—C(S)—N or N—C(S)—S—S—C(S)—N)Sulfinylamines (—N=SO)Sulfonylamines (—N=SO2)
• A61K 31/57 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
• A61P 15/00 - Drugs for genital or sexual disordersContraceptives

Abstract

The present invention relates to a system for providing feedback about the quality of real-time chest compressions for cardiopulmonary resuscitation, and a method therefor. According to the present invention, the system for providing feedback about the quality of real-time chest compressions for cardiopulmonary resuscitation comprises: one or two gloves; a first sensor which is attached to and detached from one side of the glove so as to measure the acceleration of chest compressions by a performer in real time; a second sensor which is attached to and detached from the other side of the glove so as to measure the pressure of the chest compressions by the performer in real time; and a control device which receives, in real time, the acceleration of chest compressions and the pressure of the chest compressions measured by the first sensor and the second sensor, so as to determine the current step and state of the chest compressions according to an algorithm, and which displays feedback about the determined quality of the chest compressions.

IPC Classes  ?

• A61H 31/00 - Artificial respiration by a force applied to the chestHeart stimulation, e.g. heart massage
• G09B 23/28 - Models for scientific, medical, or mathematical purposes, e.g. full-sized device for demonstration purposes for medicine
• A41D 19/00 - Gloves

Abstract

The present invention provides a reboa catheter. The reboa catheter according to an embodiment comprises: a catheter tube including a tip portion and a branch portion; and a balloon portion which is formed between the tip portion and the branch portion and inflates in a blood vessel to close at least a portion of the blood vessel at a target point, wherein the tip portion is formed at a front end of the catheter tube and inserted into a blood vessel, the branch portion is formed at an end of the catheter tube and branched, and at least one blood pressure measurement hole configured to measure blood pressure in the blood vessel may be formed in the catheter tube.

IPC Classes  ?

• A61B 17/12 - Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
• A61B 5/0215 - Measuring pressure in heart or blood vessels by means inserted into the body
• A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges

Abstract

This apparatus for predicting a sleep stage from brainwave signals by using a neural network includes: an input unit for receiving an input of a brainwave signal; a memory unit for storing a neural network model; and a processor connected to the memory unit and controlling the apparatus, wherein the input unit receives the brainwave signals from four electrode channels, the processor extracts a plurality of sequential epochs having a specific time window from the brainwave signals input from the four electrode channels and obtains output data by inputting the extracted plurality of epochs as input data to the neural network model, and the neural network model is trained to predict a sleep stage for each epoch by receiving inputs of the plurality of sequential epochs and includes a plurality of first neural network regions allocated for each epoch, and a second neural network region for processing data obtained by concatenating all pieces of data that have passed through the plurality of first neural network regions.

IPC Classes  ?

• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 5/372 - Analysis of electroencephalograms
• A61B 5/291 - Bioelectric electrodes therefor specially adapted for particular uses for electroencephalography [EEG]
• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
• G06N 3/045 - Combinations of networks

Abstract

The present invention relates to a peptide binding to both a VEGF receptor and a PDGF receptor, a use thereof, and a selection method therefor.

IPC Classes  ?

• A61K 38/18 - Growth factorsGrowth regulators
• A61P 27/02 - Ophthalmic agents
• A61P 35/00 - Antineoplastic agents
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

Abstract

The present application relates to an animal or cell having a myostatin gene in which 12 base pairs of the second exon are deleted. The present application may also comprise a composition capable of manipulating the deletion of 12 base pairs of a myostatin gene to construct the animal or the cell. The present application also relates to use of the composition for increasing muscle.

IPC Classes  ?

• A01K 67/0276 - Knock-out vertebrates
• C07K 14/475 - Growth factorsGrowth regulators
• C12N 5/071 - Vertebrate cells or tissues, e.g. human cells or tissues
• C12N 9/22 - Ribonucleases
• C12N 15/11 - DNA or RNA fragmentsModified forms thereof
• C12N 15/85 - Vectors or expression systems specially adapted for eukaryotic hosts for animal cells

Abstract

The present invention relates to a vascular clip for blood flow control, wherein the vascular clip is based on a shape-memory polymer and serves to partially occlude a vessel through which excessive blood flow passes due to the incomplete automatic regulatory function thereof so as to induce normal blood flow and release the occlusion when the automatic regulatory function recovers, the occlusion is released, whereby when applied as a device to substitute for the lost automatic regulatory function of the vessel, the vascular clip can prevent cerebral hyperperfusion syndrome in advance, thus solving problems caused by the syndrome and can eliminate the risks of removal surgery, thus providing safety and convenience for patients.

IPC Classes  ?

• A61B 17/122 - Clamps or clips, e.g. for the umbilical cord
• A61B 17/00 - Surgical instruments, devices or methods
• A61L 31/14 - Materials characterised by their function or physical properties

Abstract

The present invention relates to a synthetic medical data generation system and method for predicting postoperative complications. According to the present invention, the synthetic medical data generation system is provided, the system comprising: a medical data acquisition unit for acquiring an input vector in a form in which structured medical data related to clinical information of a patient and unstructured medical data in a text form recorded for the patient are arranged according to configuration rules; an embedding unit for embedding, in consideration of data type, the structured medical data and the unstructured medical data included in the input vector; and a synthetic medical data generation unit, which integrally learns the embedded input vector through a pre-trained deep learning-based synthetic data generation model, thereby generating structured synthetic medical data having the same form as the structured medical data.

IPC Classes  ?

• G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
• G16H 50/50 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
• G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
• G06N 20/00 - Machine learning

Abstract

The present invention relates to an apparatus and a method for detecting landmarks for evaluating breast aesthetics based on artificial intelligence, which enable detection of landmarks used for evaluating breast aesthetics by utilizing a deep learning model, and is characterized by including: an image acquisition unit configured to acquire a photograph of a breast to be evaluated for aesthetics; and landmarks detection unit configured to input the breast photograph acquired through the image acquisition unit into a pre-trained landmark detection model to detect landmarks used for evaluating breast aesthetics.

IPC Classes  ?

• G06V 40/10 - Human or animal bodies, e.g. vehicle occupants or pedestriansBody parts, e.g. hands
• G06V 10/32 - Normalisation of the pattern dimensions
• G06V 10/44 - Local feature extraction by analysis of parts of the pattern, e.g. by detecting edges, contours, loops, corners, strokes or intersectionsConnectivity analysis, e.g. of connected components
• G06V 10/82 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using neural networks

Abstract

ER71ER71. In the present invention, the differentiation into vascular endothelial cells has been optimized by identifying the differentiation efficiency according to various culture additives. In addition, the vascular endothelial cells thus obtained have enhanced immune tolerance properties and enable hindlimb salvage through angiogenesis in a mouse model of hindlimb ischemia, and thus the vascular endothelial cells prepared by the method of the present invention are expected to be usefully employable for the treatment of cardio-cerebrovascular diseases without exhibiting immune rejection when injected in vivo.

IPC Classes  ?

• C12N 5/071 - Vertebrate cells or tissues, e.g. human cells or tissues
• C07K 14/47 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from mammals
• A61K 35/44 - VesselsVascular smooth muscle cellsEndothelial cellsEndothelial progenitor cells
• A61K 35/28 - Bone marrowHaematopoietic stem cellsMesenchymal stem cells of any origin, e.g. adipose-derived stem cells
• A61P 9/00 - Drugs for disorders of the cardiovascular system
• A61P 9/10 - Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Abstract

Disclosed herein are mesoporous ceria nanoparticles for the prevention, treatment, or alleviation of ophthalmic diseases. In one aspect, having mesoporous structure with high surface area and pore size and mimicking the catalytic properties of catalase and superoxide dismutase (SOD), the mesoporous ceria nanoparticles of the present invention have excellent ability to scavenge reactive oxygen species, exhibit anti-inflammatory effects, demonstrate biocompatibility without causing acute side effects or ocular toxicity in the retina, and are recognized to provide protective effects against cellular damage and protect damaged retinal pigment epithelial (RPE) cells and photoreceptors under high oxidative stress. Therefore, the nanoparticles can be utilized for the prevention, treatment, or alleviation of macular degeneration and various oxidative stress-mediated ophthalmic diseases.

IPC Classes  ?

• A61K 9/51 - Nanocapsules
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61P 27/02 - Ophthalmic agents
• A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]
• A61P 39/06 - Free radical scavengers or antioxidants
• A61K 33/24 - Heavy metalsCompounds thereof
• A61K 38/00 - Medicinal preparations containing peptides
• A61K 39/00 - Medicinal preparations containing antigens or antibodies

Abstract

In an aspect, the present disclosure relates to a method for predicting bone mineral density, the method comprising the steps of: measuring a plantar pressure while a subject walks; and predicting bone mineral density on the basis of the measured plantar pressure. In addition, in another aspect, the present disclosure relates to a computer program stored in a medium so as to execute, in combination with hardware, the method for predicting bone mineral density. In yet another aspect, the present disclosure relates to a bone mineral density prediction device for executing the method for predicting bone mineral density, the bone mineral density prediction device comprises: a measurement module for measuring a plantar pressure while a subject walks; and a prediction module for predicting the bone mineral density on the basis of the measured plantar pressure.

IPC Classes  ?

• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 5/103 - Measuring devices for testing the shape, pattern, size or movement of the body or parts thereof, for diagnostic purposes

Abstract

In an aspect, the present disclosure relates to a method for assisting diagnosis of osteoporosis, comprising the steps of: measuring plantar pressure when a subject walks; and predicting the possibility of the subject being diagnosed with osteoporosis on the basis of the measured plantar pressure. In addition, in another aspect, the present disclosure relates to a computer program stored in a medium to execute the method for assisting diagnosis of osteoporosis, in combination with hardware. In another aspect, the present disclosure relates to an apparatus for assisting diagnosis of osteoporosis, performing the method for assisting diagnosis of osteoporosis, the apparatus comprising: a measurement module for measuring plantar pressure when a subject walks; and a prediction module for predicting the possibility of the subject being diagnosed with osteoporosis on the basis of the measured plantar pressure.

IPC Classes  ?

• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 5/103 - Measuring devices for testing the shape, pattern, size or movement of the body or parts thereof, for diagnostic purposes

Abstract

The present invention relates to a pharmaceutical composition for preventing or treating colorectal cancer comprising estrogen and an anti-PD-L1 antibody, and a composition comprising estrogen for promoting anti-cancer effects of an anti-PD-L1 antibody. Particularly, a combination therapy of estrogen and an anti-PD-L1 antibody carried out in a colorectal cancer model exhibits synergistic effects in tumor growth inhibition that are greater than those of when each is used alone, and induces changes in tumor-related cell populations, and thus is effective as a treatment in precision medicine.

IPC Classes  ?

• A61K 31/566 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. oestrane, oestradiol having an oxo group in position 17, e.g. oestrone
• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• A61P 35/00 - Antineoplastic agents
• C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants

Abstract

A device for analyzing a medical image by using artificial intelligence according to an embodiment: inputs a medical image to a first model to extract a feature vector that a second model uses to perform a first task; inputs the feature vector to the second model to cause the second model to perform the task; provides a first medical result describing a health state based on the medical image on the basis of an output result of the second model; and performs a second task requested by a user of the device for the first medical result, wherein the second task comprises: a first additional task of transferring the first medical result to the outside; and a second additional task of performing secondary analysis including at least one of assisted decision-making and difference analysis on the first medical result.

IPC Classes  ?

• G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
• G16H 30/20 - ICT specially adapted for the handling or processing of medical images for handling medical images, e.g. DICOM, HL7 or PACS
• G16H 50/50 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
• G16H 80/00 - ICT specially adapted for facilitating communication between medical practitioners or patients, e.g. for collaborative diagnosis, therapy or health monitoring
• G06F 3/0482 - Interaction with lists of selectable items, e.g. menus
• G06F 3/04817 - Interaction techniques based on graphical user interfaces [GUI] based on specific properties of the displayed interaction object or a metaphor-based environment, e.g. interaction with desktop elements like windows or icons, or assisted by a cursor's changing behaviour or appearance using icons
• G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
• A61B 5/318 - Heart-related electrical modalities, e.g. electrocardiography [ECG]
• A61B 6/50 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body partsApparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific clinical applications
• G06N 3/0464 - Convolutional networks [CNN, ConvNet]

Abstract

Provided are a patient monitoring device capable of not only protecting patient personal information but also conveniently linking vital sign data to an electronic medical record (EMR) server, and an electronic medical record (EMR) system comprising same. The patient monitoring device comprises: a scanner for recognizing personal identification information of a patient by scanning a barcode attached to the patient's wrist; a sensor attached to the patient so as to measure vital sign data; a first display for displaying the vital sign data measured by the sensor in real time; a controller for generating a QR code by combining the vital sign data measured at a predetermined time point with the personal identification information in response to a first execution event; and a second display for displaying the QR code in response to a second execution event.

IPC Classes  ?

• G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
• G16H 15/00 - ICT specially adapted for medical reports, e.g. generation or transmission thereof
• G16H 80/00 - ICT specially adapted for facilitating communication between medical practitioners or patients, e.g. for collaborative diagnosis, therapy or health monitoring
• A61B 5/021 - Measuring pressure in heart or blood vessels
• A61B 5/08 - Measuring devices for evaluating the respiratory organs
• A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
• A61B 5/024 - Measuring pulse rate or heart rate
• A61B 5/01 - Measuring temperature of body parts
• A61B 5/318 - Heart-related electrical modalities, e.g. electrocardiography [ECG]
• G06Q 50/10 - Services

Abstract

The present invention relates to a prodrug compound activated by a fibroblast activation protein (FAP).

IPC Classes  ?

• C07D 401/14 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
• A61K 31/496 - Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
• A61P 43/00 - Drugs for specific purposes, not provided for in groups
• A61K 47/54 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
• A61K 31/404 - Indoles, e.g. pindolol
• A61K 31/4439 - Non-condensed pyridinesHydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
• A61K 31/501 - PyridazinesHydrogenated pyridazines not condensed and containing further heterocyclic rings

Abstract

A head-up system for cardiopulmonary resuscitation is disclosed. The device relates to a device for supporting the head of a patient during cardiopulmonary resuscitation and, more specifically, to a head-up system for cardiopulmonary resuscitation, and a control method therefor, the system positioning the head of the patient to be higher than the heart and horizontally tilting the head of the patient such that neck bending is prevented so that the airway and blood vessels are open, and thus cerebral perfusion pressure and cerebral blood flow during cardiopulmonary resuscitation can be increased, and, simultaneously, preventing force that compresses the chest during cardiopulmonary resuscitation from being absorbed and reduced.

IPC Classes  ?

• A61H 31/00 - Artificial respiration by a force applied to the chestHeart stimulation, e.g. heart massage
• A61G 1/04 - Parts, details or accessories, e.g. head-, foot-, or like rests specially adapted for stretchers
• A61G 1/01 - Sheets specially adapted for use as or with stretchers

Abstract

The present invention relates to an apparatus and method for screening for autism on the basis of user gaze monitoring. According to the present invention, the apparatus for screening for autism on the basis of user gaze monitoring, comprises: a user monitoring unit that monitors the gaze and movement of a user through a camera while image content is output on a display, and obtains real-time gaze coordinates; a layer analysis unit that extracts a plurality of elements of interest including the entire area and a partial area of each object related to an object and a character appearing in an image of the display for each hour, and divides the image into a plurality of types of layers according to the type of the element of interest; a time-series data deriving unit that derives, on the basis of the plurality of types of layers and the real-time gaze coordinates, time-series response data in which a time interval, during which the user gazed at the element of interest on each type of layer while watching the image, is recorded for each time; and a determination unit for determining autism by applying the time-series response data to a pre-constructed autism screening model.

IPC Classes  ?

• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 5/16 - Devices for psychotechnicsTesting reaction times
• A61B 3/113 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for determining or recording eye movement
• A61B 3/00 - Apparatus for testing the eyesInstruments for examining the eyes
• G16H 10/20 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for electronic clinical trials or questionnaires
• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
• G16H 50/50 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders

Abstract

The present invention relates to a method and apparatus for automatically inspecting a change in output and performance of a mechanical wave generating device for irradiating mechanical waves, such as shock waves and ultrasonic waves, on the basis of an ultrasonic image by using artificial intelligence technology. A method for monitoring the output and/or the performance of the mechanical wave generating device on the basis of the ultrasonic image by using AI uses an ultrasonic imaging device configured to obtain an ultrasonic image for imaging acoustic characteristics of a medium through which the mechanical waves propagates, and AI for recognizing and learning the ultrasonic image. The output and/or the performance of the mechanical wave generating device can be monitored through the ultrasonic image of the medium to which the mechanical waves are irradiated.

IPC Classes  ?

• A61B 8/00 - Diagnosis using ultrasonic, sonic or infrasonic waves
• G06N 20/00 - Machine learning

Abstract

The present invention relates to a device for supporting the head of a patient during cardiopulmonary resuscitation and, more specifically, to a head-up system for cardiopulmonary resuscitation using an airbag and a method of controlling same. The head-up system is configured such that the patient's head is positioned higher than the heart to increase cerebral perfusion pressure and cerebral blood flow during cardiopulmonary resuscitation while the patient's head is tilted horizontally to prevent neck flexion so as to maintain airway and vascular patency. In addition, the head-up system is configured such that the compressive force applied to the chest during cardiopulmonary resuscitation is not absorbed or reduced.

IPC Classes  ?

• A61H 31/00 - Artificial respiration by a force applied to the chestHeart stimulation, e.g. heart massage
• A61G 1/04 - Parts, details or accessories, e.g. head-, foot-, or like rests specially adapted for stretchers
• A61G 1/01 - Sheets specially adapted for use as or with stretchers

Abstract

The present invention relates to a ligand compound that is activated by or binds to a fibroblast activation protein (FAP).

IPC Classes  ?

• C07D 401/12 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
• A61K 49/00 - Preparations for testing in vivo
• A61K 51/04 - Organic compounds
• A61K 31/4439 - Non-condensed pyridinesHydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
• A61P 43/00 - Drugs for specific purposes, not provided for in groups
• A61K 47/54 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
• A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit

Abstract

A method for training an artificial intelligence model for image compatibility of different OCT equipment according to an embodiment of the present invention may include the steps of: acquiring a training data set including a plurality of first eyeball images photographed by first OCT equipment and a plurality of second eyeball images photographed by second OCT equipment; and training the artificial intelligence model to enable mutual conversion between the first eyeball images and the second eyeball images, wherein in a training process of the artificial intelligence model, a loss function designed by targeting a boundary of a retinal nerve fiber layer included in each eyeball image may be used.

IPC Classes  ?

• A61B 3/00 - Apparatus for testing the eyesInstruments for examining the eyes
• A61B 3/10 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions
• A61B 3/12 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes
• G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
• G06N 3/088 - Non-supervised learning, e.g. competitive learning

Abstract

Provided are a method and an apparatus for predicting blood loss in a patient undergoing surgery. The method for predicting blood loss comprises the steps of: detecting a gauze image from a first image of a surgical site of a patient; setting a reference blood color of the patient on the basis of the first image; inputting the reference blood color and the gauze image to a pre-trained blood loss estimation model to estimate the ratio of blood and body fluid absorbed in the gauze; and predicting the amount of lost blood absorbed in the gauze on the basis of the estimated ratio of blood and body fluid.

IPC Classes  ?

• A61B 5/02 - Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
• A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
• G16H 30/20 - ICT specially adapted for the handling or processing of medical images for handling medical images, e.g. DICOM, HL7 or PACS
• G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing

Abstract

22in vitroin vivoin vivo experiments, and thus the present invention may be useful as a regeneration accelerating agent due to having improved bioactivity and antioxidant effects.

IPC Classes  ?

• A61K 9/50 - Microcapsules
• A61K 9/10 - DispersionsEmulsions
• A61K 38/18 - Growth factorsGrowth regulators
• A61P 39/06 - Free radical scavengers or antioxidants
• A61P 17/02 - Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
• A61P 35/00 - Antineoplastic agents
• A23L 33/10 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives
• A61K 8/11 - Encapsulated compositions
• A61Q 19/00 - Preparations for care of the skin

Abstract

A method for providing a user interface for controlling a magnetic catheter by changing an external magnetic field, including steps of: acquiring a k-th subject spatial image by photographing a subject space from a k-th subject spatial absolute coordinate point, displaying a k-th selection indicating symbol at a k-th subject spatial relative coordinate point, which is a relative coordinate point selected by a user with respect to the k-th subject spatial absolute coordinate point as its origin, displaying a k-th visualized coordinate space to expose a yaw and a pitch of a current direction of the magnetic catheter, and continuously exposing the yaw and the pitch of the current direction of the magnetic catheter as time passes.

IPC Classes  ?

• A61M 25/01 - Introducing, guiding, advancing, emplacing or holding catheters

Abstract

The present invention relates to a combination regimen of Decitabine and Belotecan for preventing or treating ovarian cancer, and provides a pharmaceutical composition for preventing or treating ovarian cancer, the pharmaceutical composition being characterized by comprising Decitabine or a pharmaceutically acceptable salt or solvate thereof as an active ingredient, wherein the pharmaceutical composition is administered in combination with Belotecan or a pharmaceutically acceptable salt or solvate thereof.

IPC Classes  ?

• A61K 31/706 - Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
• A61K 31/4745 - QuinolinesIsoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenanthrolines
• A61P 35/00 - Antineoplastic agents
• A61P 35/04 - Antineoplastic agents specific for metastasis
• A23L 33/10 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives
• A23K 20/137 - Heterocyclic compounds containing two hetero atoms, of which at least one is nitrogen

Abstract

The present invention relates to an antibody or an antigen-binding fragment thereof comprising a single domain antibody specifically binding to mesothelin, an antibody conjugate comprising same, a pharmaceutical composition for preventing or treating cancer or a tumor, and a composition for diagnosing or monitoring cancer or a tumor. When the antibody or composition comprising same is used, mesothelin-related cancer or tumors can be effectively prevented, treated, or diagnosed.

IPC Classes  ?

• C07K 16/30 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
• A61K 47/68 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
• A61P 35/00 - Antineoplastic agents
• G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer
• A61K 39/00 - Medicinal preparations containing antigens or antibodies

Abstract

A method and device for providing clinical evaluation information by using an image are provided. The method for providing clinical evaluation information by using an image includes the steps of: actively or passively acquiring a photographed image, estimating a 3D posture of a person using only one of depth information and 2D body coordinate information of the person, obtained based on the photographed image, or by integrating the two pieces of information, analyzing a clinical determination criteria indicator according to the person's posture, on the basis of the 3D posture to analyze the person's motion, and generating and providing person's clinical evaluation information based on the clinical determination criteria indicator.

IPC Classes  ?

• G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
• G06T 7/246 - Analysis of motion using feature-based methods, e.g. the tracking of corners or segments
• G06T 7/70 - Determining position or orientation of objects or cameras
• G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment

Abstract

Disclosed is a micro-medical robot-based guidewire for vascular intervention. The guidewire includes: a core shaft; an outer coil surrounding an outer circumference of a distal portion of the core shaft; a tip end to which a front end of the core shaft and/or a front end of the outer coil is connected; an outer joining unit configured to connect a rear end of the outer coil and a rear end of the core shaft; an inner joining unit, disposed inside the outer coil, configured to connect the outer coil and an outer surface of the core shaft; and at least two magnetic bodies, disposed at a specific section in the inner space of the outer coil, wherein each of the magnetic bodies with each through-hole being formed at each center thereof is configured to allow the front end of the core shaft to go through said each through-hole.

IPC Classes  ?

• A61B 34/30 - Surgical robots
• A61B 34/00 - Computer-aided surgeryManipulators or robots specially adapted for use in surgery
• A61L 31/02 - Inorganic materials
• A61L 31/08 - Materials for coatings
• A61M 25/01 - Introducing, guiding, advancing, emplacing or holding catheters
• A61M 25/09 - Guide wires

Abstract

The present invention relates to a method for training a model for predicting abdominal surgery information, which is performed by a computing device, the method comprising a step of training an artificial neural network model by using medical image data and masking data labeled with the degree of adhesion between the peritoneum and organs such that, when a medical image is input, the model outputs abdominal surgery-related information of the input medical image.

IPC Classes  ?

• G16H 50/50 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
• G16H 30/20 - ICT specially adapted for the handling or processing of medical images for handling medical images, e.g. DICOM, HL7 or PACS
• G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
• G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
• G06N 3/08 - Learning methods
• A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
• A61B 6/03 - Computed tomography [CT]
• A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging

Abstract

The present invention relates to a mechanical wave generating apparatus for irradiating mechanical waves such as shock waves, ultrasonic waves, or the like. The mechanical wave generating apparatus comprises: a mechanical wave generating unit for generating mechanical waves; a mechanical wave sensor for sensing the mechanical waves generated by the mechanical wave generating unit; and a monitoring unit for automatically monitoring sound output information of the mechanical wave generating unit by using a signal recorded by the mechanical wave sensor.

IPC Classes  ?

• A61B 17/225 - Surgical instruments, devices or methods for extracorporeal shock wave lithotripsy [ESWL], e.g. by using ultrasonic waves
• A61N 7/00 - Ultrasound therapy
• A61B 17/00 - Surgical instruments, devices or methods

Abstract

The present invention provides a scleral marker and a marking apparatus comprising same. The marking apparatus according to an embodiment comprises: a body; a connection part extending from the body in the longitudinal direction of the body; and a marking part coupled to the connection part, wherein the marking part includes a plurality of markers in contact with an eyeball, the markers can be disposed to be spaced apart from each other by a predetermined distance while forming an arc having a curvature corresponding to the eyeball, the plurality of markers comprise a first marker and a second marker, and the first marker and the second marker may be disposed in directions orthogonal to each other when viewed from above.

IPC Classes  ?

• A61F 9/007 - Methods or devices for eye surgery
• A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
• A61B 17/00 - Surgical instruments, devices or methods

Abstract

The present specification relates to a microRNA biomarker for metabolic disease prediction or diagnosis, and more specifically, by measuring the expression levels of miR 122-5p, miR 93-5p, miR 17-5p, miR 20a-5p, miR 20b-5p, and miR 106a-5p, metabolic disease may be predicted or diagnosed with high accuracy, or a prognosis of metabolic disease may be predicted.

IPC Classes  ?

• C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material

Abstract

An apparatus for predicting homologous recombination deficiency (HRD) using artificial intelligence, according to the present invention, comprises: a data collection unit that collects transcript data, gene expression level data, and homologous recombination deficiency score data of various types of cancer patients; a first candidate gene selection unit; a first prediction model generation unit; a second candidate gene selection unit; a third candidate gene selection unit; a second prediction model generation unit; and a homologous recombination deficiency prediction value calculation unit. Accordingly, homologous recombination deficiency for individual samples can be more accurately predicted.

IPC Classes  ?

• G16B 40/20 - Supervised data analysis
• G16B 25/10 - Gene or protein expression profilingExpression-ratio estimation or normalisation
• G16B 30/10 - Sequence alignmentHomology search
• G16B 45/00 - ICT specially adapted for bioinformatics-related data visualisation, e.g. displaying of maps or networks
• G06N 20/00 - Machine learning
• G16B 20/20 - Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection

Abstract

Disclosed is an apparatus for evaluating a virtual surgery based on an evaluation index. The present embodiment provides an apparatus for evaluating a virtual surgery based on an evaluation index, which is capable of: generating an evaluation index based on an average point of three-dimensional coordinates which are obtained through a repeated performance of a virtual simulation by an operating surgeon (evaluator) with a high surgical skill level; and extracting the three-dimensional coordinates obtained in a process of performing the virtual simulation by a surgeon-in-training (subject) with a low surgical skill level and comparing the same with the above-generated evaluation index so as to evaluate the virtual surgery performed by the surgeon-in-training.

IPC Classes  ?

• G09B 23/28 - Models for scientific, medical, or mathematical purposes, e.g. full-sized device for demonstration purposes for medicine
• G09B 23/30 - Anatomical models

Abstract

The present invention relates to a decellularized nerve conduit prepared using a supercritical fluid extraction process. More specifically, the present invention relates to a decellularized nerve conduit having optimized mechanical properties such as tensile strength and elastic restoring force by using a supercritical fluid extraction process. The nerve conduit according to the present invention is decellularized without a surfactant treatment, so that not only are mechanical properties maintained, but there is no toxicity due to residual surfactant, and transplant rejection is minimized, so that the nerve conduit can be usefully employed in treating patients with nerve defects.

IPC Classes  ?

• A61F 2/04 - Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
• A61L 27/36 - Materials for prostheses or for coating prostheses containing ingredients of undetermined constitution or reaction products thereof

Abstract

The present specification relates to a system for measuring the metastatic potential of cancer cells and a method for measuring the metastatic potential of cancer cells by using same, the system comprising a microenvironment mimicking part and a measurement unit, in which the microenvironment mimicking part comprises: a primary tumor layer including cancer cells and vascular endothelial cells; and a metastasis layer including a gel. The system according to an aspect of the present invention has excellent effects such as being able to co-culture cancer cells and vascular endothelial cells, mimic the metastasis of cancer cells that is caused by a vascular layer formed by vascular endothelial cells during co-culture, easily observe and measure the metastatic potential of cancer cells by using a marker that is expressed specifically in cancer cells, and mimic the metastasis of cancer cells and measure the metastatic potential thereof.

IPC Classes  ?

• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing
• C12N 5/071 - Vertebrate cells or tissues, e.g. human cells or tissues
• C12N 5/09 - Tumour cells

Abstract

The objective of the present invention is to provide a brain water monitoring method and apparatus based on near-infrared spectroscopy, which can non-invasively and accurately measure the brain water activity of brain tissue according to sleep-wakefulness and a sleep structure on the basis of near-infrared spectroscopy without injecting a contrast agent, an aqueous solution, or the like to the human body (intravenously or intrathecally). To achieve the objective, the present invention comprises: a calculation step of calculating the fractions of oxidized hemoglobin, reduced hemoglobin, and water on the basis of signals measured by near-infrared spectroscopy; an extraction step of extracting a pure water fraction from the water fraction calculated in the calculation step; and an output step of outputting the water fraction extracted in the extraction step.

IPC Classes  ?

• A61B 5/1455 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using optical sensors, e.g. spectral photometrical oximeters
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 5/03 - Measuring fluid pressure within the body other than blood pressure, e.g. cerebral pressure
• A61M 27/00 - Drainage appliances for wounds, or the like

Abstract

A method for automatically evaluating the smoothness of voluntary movements of an infant, according to one embodiment of the present invention, comprises the steps of: obtaining a two-dimensional video of the infant who is moving voluntarily; obtaining position coordinate data of joints of the infant for each frame of the video by using a deep learning-based pose prediction model; and quantifying the smoothness of the voluntary movements of the infant on the basis of the position coordinate data of the joints.

IPC Classes  ?

• A61B 5/11 - Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb
• G06N 3/0464 - Convolutional networks [CNN, ConvNet]

Abstract

The present invention relates to a method for predicting reactivity to anticancer drugs by analyzing genomic DNA methylation status and, more specifically to a method for predicting reactivity to anticancer drugs by analyzing the methylation status of adjacent CpG sites in genomic DNA. The method of the present invention can accurately predict reactivity to anticancer drugs by using the methylation disorderness of CpG sites in genomic DNA, and thus can be very useful in the selection of drugs for cancer patient treatment.

IPC Classes  ?

• C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer

Abstract

A method for providing auxiliary information on dysphagia by using voice analysis, the method comprising: obtaining, via a sensor array, the pre-food swallowing voice or vibration and the post-food swallowing voice or vibration of the subject, respectively, and providing auxiliary information on dysphagia by comparing one or more characteristic values of each of said voice or vibration, wherein said auxiliary information on dysphagia comprises characteristic information about the residue state concerning one or more of the following: whether food has been aspirated into the airway after food swallowing by the subject, the presence or absence of residues, the location of residues, and the amount of residues.

IPC Classes  ?

• G10L 25/66 - Speech or voice analysis techniques not restricted to a single one of groups specially adapted for particular use for comparison or discrimination for extracting parameters related to health condition
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons

Abstract

The present invention relates to: a DNA methylation biomarker for the early diagnosis of metabolic dysfunction–associated steatohepatitis and the diagnosis of high-risk metabolic dysfunction–associated steatohepatitis; and a use thereof. Using the composition and the method of the present invention not only enables the early diagnosis of metabolic dysfunction–associated steatohepatitis but also enables the diagnosis of high-risk metabolic dysfunction–associated steatohepatitis, and makes it possible to obtain data with very stable numerical values based on DNA methylation from small amounts of blood, and can reduce diagnosis costs.

IPC Classes  ?

• C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material

Abstract

The present invention relates to a composition for preventing, alleviating and/or treating alopecia or gray hair (or poliosis), and the like, and was completed by confirming that an aldehyde dehydrogenase 2 (ALDH2) activator promotes hair follicle formation and hair growth and has an excellent effect on inhibiting the oxidative stress of hair follicles. Therefore, the ALDH2 activator according to the present invention can be used as a preparation for preventing, alleviating and/or treating alopecia and gray hair. Furthermore, combined treatment of the ALDH2 activator and minoxidil exhibited better alopecia prevention and treatment effects. Therefore, ALDH2 according to the present invention not only effectively promotes hair growth by itself, but also is expected to be usefully used in combination with minoxidil in the medical, beauty and food fields in order to prevent, alleviate and treat alopecia.

IPC Classes  ?

• A61K 31/36 - Compounds containing methylenedioxyphenyl groups, e.g. sesamin
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 31/506 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
• A61P 17/14 - Drugs for dermatological disorders for baldness or alopecia

Abstract

Provided is a cognitive impairment determination method that discloses a model for determining cognitive impairment based on a gait feature value measured by an accelerometer attached to a subject, discloses a configuration for determining cognitive impairment by using a model including a mathematical linear regression equation that includes a gait speed and step time variability as predictors by receiving personal data and gait data, easily and quickly screens for cognitive impairment, such as dementia, regardless of a root cause, and accurately determines even cognitive impairment in an early stage.

IPC Classes  ?

• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 5/11 - Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb
• A61B 5/16 - Devices for psychotechnicsTesting reaction times
• G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation

Abstract

The present application relates to a DNA methylation biomarker for diagnosing liver fibrosis and a use thereof. By using a composition and a method of the present invention, liver fibrosis can be diagnosed, data can be obtained from a small amount of blood with very stable values based on DNA methylation, and diagnosis costs can be reduced.

IPC Classes  ?

• C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material

Abstract

Provided is an intraperitoneal fluid injection system. An intraperitoneal fluid injection system according to an embodiment of the present invention comprises: a shaft which is partially inserted into a fluid injection target; an injection nozzle which is attached to one end of the shaft while forming a certain angle with respect to a direction in which the shaft extends and comprises a nozzle tip configured to inject a fluid; and a driving unit which is configured to rotate the shaft about the longitudinal axis of the shaft as a rotational axis.

IPC Classes  ?

• A61M 11/00 - Sprayers or atomisers specially adapted for therapeutic purposes
• A61M 11/06 - Sprayers or atomisers specially adapted for therapeutic purposes of the injector type
• A61M 31/00 - Devices for introducing or retaining media, e.g. remedies, in cavities of the body

Abstract

The present invention relates to an anticancer agent leakage prevention system comprising: a sealing unit which is attached to the outside of a human body and has a first space therein; a sealing unit discharge unit connected to the sealing unit so as to discharge an anticancer agent leaked in the first space; a cover unit surrounding the human body and having a second space therein; and a cover unit discharge unit connected to the cover unit so as to discharge the anticancer agent leaked in the second space. The system accordingly prevents the anticancer agent from leaking to the outside.

IPC Classes  ?

• A61M 11/00 - Sprayers or atomisers specially adapted for therapeutic purposes
• A61M 13/00 - Insufflators for therapeutic or disinfectant purposes
• A61M 31/00 - Devices for introducing or retaining media, e.g. remedies, in cavities of the body
• A61B 50/00 - Containers, covers, furniture or holders specially adapted for surgical or diagnostic appliances or instruments, e.g. sterile covers

Abstract

The present invention relates to a novel spiro-hydantoin derivative exhibiting metalloprotease ADAMTS-4 inhibitory activity, and a use thereof. The spiro-hydantoin derivative according to the present invention is useful for the prevention or treatment of diseases caused by liver injury such as a fatty liver and liver cirrhosis.

IPC Classes  ?

• C07D 405/12 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
• A61K 31/4184 - 1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
• A61K 31/496 - Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
• A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
• A61P 43/00 - Drugs for specific purposes, not provided for in groups
• C07D 235/02 - Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
• C07D 401/12 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
• C07D 403/12 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a chain containing hetero atoms as chain links
• C07D 409/12 - Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
• C07D 405/14 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Abstract

According to an embodiment of the present disclosure, a method of detecting a white matter lesion based on a medical image performed by a computing device is disclosed. The method may include: receiving a medical image including at least one brain region; and estimating a first white matter lesion and a second white matter lesion based on the medical image using a pre-trained neural network model.

IPC Classes  ?

• G06T 7/11 - Region-based segmentation

Abstract

Provided is a method for preventing, alleviating or treating dry eye syndrome or meibomian gland dysfunction that may be caused by environmental stress or various diseases, including administering 1,5-O-dicaffeoylquinic acid which reduces corneal epithelial loss, increases the amount of tear production, inhibits inflammation of the lacrimal and meibomian glands, increases the area of the meibomian gland, increases the survival rate of corneal epithelial cells in a hyperosmotic environment, and can inhibit cell death, and thus is expected to be used as a therapeutic agent for various eye diseases.

IPC Classes  ?

• A61K 31/7028 - Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
• A61P 27/04 - Artificial tearsIrrigation solutions

Abstract

A device for training an ear lobe crease detection model according to one embodiment comprises: one or more processors; and a memory for storing commands executed by the one or more processors, wherein the one or more processors are configured to: select some slices as learning target slices from MRI volume data generated by an MRI device photographing the head of a target patient; generate learning data to be used in a deep learning-based segmentation model that detects an ear lobe crease from the MRI volume data on the basis of the learning target slices; and train the model to detect an ear lobe crease from the MRI volume data by inputting the learning data into the deep learning-based segmentation model.

IPC Classes  ?

• A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
• G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients

Abstract

The present invention relates to an injectable hydrogel rod using a crosslinked hydrogel, a method for manufacturing same, and biomedical use thereof. According to the present invention, by adjusting the contents of a polymer, an enzyme and hydrogen peroxide to a certain ratio to manufacture an injectable hydrogel rod, the initial release amount of a drug injected into the hydrogel rod is controlled, and thus, compared to existing hydrogel-based injectable implants, the hydrogel rod exhibits sustained release above an effective concentration for a long period of time and greatly reduces elimination into surrounding tissues, which may result in an increased therapeutic effect and remarkably reduced side effects.

IPC Classes  ?

• A61L 27/52 - Hydrogels or hydrocolloids
• A61L 27/02 - Inorganic materials
• A61L 27/14 - Macromolecular materials
• A61L 27/54 - Biologically active materials, e.g. therapeutic substances

Abstract

The present disclosure relates to a method of detecting an integration site of a vector in a genome. According to the method of the present disclosure, it is possible to simply and quickly analyze a quantitative integration site of a viral vector with respect to a plurality of DNA motifs (sites) in a genome. Therefore, it can be useful for monitoring the safety and effectiveness of a gene therapy agent.

IPC Classes  ?

• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
• C12N 15/86 - Viral vectors
• C12Q 1/686 - Polymerase chain reaction [PCR]
• G16B 30/10 - Sequence alignmentHomology search

Abstract

The present specification discloses an intraocular drug delivery system using magnetic nanoparticles. In an aspect, unlike existing drug delivery systems, the drug delivery system of the present invention can adjust and control, from outside the eyeball, drug movement and a drug release position after intraocular drug injection, and can replace repeated expensive injection treatments, and thus can reduce burden on patients, medical personnel, and national healthcare finances.

IPC Classes  ?

• A61K 41/00 - Medicinal preparations obtained by treating materials with wave energy or particle radiation
• A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 31/573 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
• A61P 27/02 - Ophthalmic agents

Abstract

The present invention relates to a method for producing a heterograft, comprising the steps of: (a) decellularizing porcine pericardial tissue; (b) treating the decellularized porcine pericardial tissue with alpha-galactosidase to remove a galactose-alpha-1,3-galactose (α-Gal) xenoantigen; (c) treating the porcine pericardial tissue from which the α-Gal xenoantigen has been removed, with peptide-N-glycosidase F to remove non-Gal xenoantigens, including N-glycolneuramic acid (Neu5Gc); and (d) treating the porcine pericardial tissue from which the α-Gal xenoantigen and the non-Gal xenoantigens have been removed, with glutaraldehyde and fixing same. Also, the present invention relates to a heterograft (e.g., a prosthetic heart valve) produced by the production method

IPC Classes  ?

• C12N 9/80 - Hydrolases (3.) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides

Abstract

In the present invention process, the inventors have confirmed that the intracellular ATP and mitochondrial membrane potentials of cells isolated from hearing-impaired patients having mutations in the BCAP31 gene are significantly lower than those of normal persons. The finding indicates that the hearing-impaired patients having mutations in the BCAP31 gene have significantly lower-functioning mitochondria. In addition, susceptibility to cisplatin-induced cytotoxicity has also been confirmed to increase. On the other hand, treating lymphoid cell lines of the hearing-impaired patients with isolated mitochondria derived from stem cells has been confirmed to increase the activity of intracellular mitochondria and reduce cisplatin-induced cytotoxicity. Furthermore, the functioning of intracellular mitochondria has also been confirmed to recover when the isolated mitochondria derived from stem cells were applied to lymphocyte cell lines derived from hearing-impaired patients having mutations in the ferredoxin reductase (FDXR) gene, and fibroblasts derived from hearing-impaired patients having mitochondrial gene mutation (m.A1555G). Therefore, the mitochondria according to the present invention can effectively alleviate or treat hereditary hearing impairment.

IPC Classes  ?

• A61K 35/12 - Materials from mammalsCompositions comprising non-specified tissues or cellsCompositions comprising non-embryonic stem cellsGenetically modified cells
• A61K 35/28 - Bone marrowHaematopoietic stem cellsMesenchymal stem cells of any origin, e.g. adipose-derived stem cells
• A61P 27/16 - Otologicals
• C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material

Abstract

The present invention relates to: a compound including a novel structure capable of specifically bonding to a prostate specific membrane antigen (PSMA); and a use of the compound for imaging, diagnosing, or treating prostate cancer.

IPC Classes  ?

• A61K 51/04 - Organic compounds
• A61K 51/12 - Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes
• A61K 49/00 - Preparations for testing in vivo
• C07D 273/01 - Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups having one nitrogen atom
• C07D 311/82 - Xanthenes
• C07D 209/18 - Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
• C07D 233/64 - Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine

Abstract

The present invention relates to a method for optimizing percutaneous pulmonary artery valve insertion by using a patient-specific model and in vitro simulation circulation through 3D printing, to find an optimal percutaneous pulmonary artery valve size and an optimal insertion position in order to increase a success rate of the percutaneous pulmonary artery valve insertion. In this regard, the present invention includes the steps of: obtaining a computed tomography (CT) image by performing CT on a heart; generating a 3D printing file format after performing 3D modeling by subdividing the heart and blood vessels on the basis of the CT image; and manufacturing an outflow path model (10) corresponding to an outflow path of the right ventricle of a person to be photographed by performing 3D printing using the 3D printing file.

IPC Classes  ?

• A61F 2/24 - Heart valves
• G09B 23/30 - Anatomical models
• B33Y 80/00 - Products made by additive manufacturing
• B33Y 50/00 - Data acquisition or data processing for additive manufacturing

Abstract

Disclosed in the present specification are a composition for improving, enhancing, or restoring the function of pancreatic β cells aged by pregnancy and childbirth, and biomarkers for predicting or diagnosing the function of pancreatic β cells aged by pregnancy and childbirth. In one aspect, the composition of the present invention can effectively enhance the proliferation of pancreatic β cells aged by pregnancy, childbirth, and multiple births by containing dasatinib and quercetin, and the biomarkers of the present invention are used such that conditions caused by pregnancy, childbirth and multiple births, such as an increased cellular stress of pancreatic β cells, impaired cellular respiration and secretory function, or decreased cell proliferation capacity can be predicted or diagnosed.

IPC Classes  ?

• A61K 31/506 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
• A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
• A61P 3/10 - Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
• A23L 33/10 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives
• C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

Abstract

According to various embodiments, there may be provided a method and apparatus for realizing an operation of an object on the basis of hand movement in a mixed reality, the method comprising the steps of: realizing a three-dimensional reconstruction model generated for a specific patient in a mixed reality space; detecting an insertion object provided to function with the three-dimensional reconstruction model and a hand of a user manipulating the insertion object; determining movement of the insertion object corresponding to hand movement of the user; and realizing the movement of the insertion object inserted into the three-dimensional reconstruction model.

IPC Classes  ?

• G06F 3/01 - Input arrangements or combined input and output arrangements for interaction between user and computer
• G06T 19/00 - Manipulating 3D models or images for computer graphics
• G06F 3/0484 - Interaction techniques based on graphical user interfaces [GUI] for the control of specific functions or operations, e.g. selecting or manipulating an object, an image or a displayed text element, setting a parameter value or selecting a range
• A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
• A61B 6/03 - Computed tomography [CT]
• A61B 8/08 - Clinical applications

Abstract

Provided are an apparatus for diagnosing a disease and a method for diagnosing same. The apparatus includes a pump for pumping respiratory gas, a first pre-treatment portion connected to the pump and removing moisture and bad breath in the respiratory gas, and a volatile organic compound detector connected between the first pre-treatment portion and the pump and detecting volatile organic compounds in the respiratory gas.

IPC Classes  ?

• G01N 33/497 - Physical analysis of biological material of gaseous biological material, e.g. breath
• G01N 1/22 - Devices for withdrawing samples in the gaseous state
• G01N 33/00 - Investigating or analysing materials by specific methods not covered by groups

Abstract

The gait assistance mechanism according to one example of the present invention may comprise one or more tendons connecting an upper limb, a trunk, and a lower limb of a wearer and a fixing part fixing the one or more tendons to the body of the wearer, and the one or more tendons may comprise a driving tendon connecting the lower limb and the upper limb on the same side of the wearer.

IPC Classes  ?

• A61H 3/00 - Appliances for aiding patients or disabled persons to walk about

Abstract

The present specification provides a method for providing information on ulcerative colitis by means of a processor, the method comprising: a step for receiving a Korean Ulcerative Colitis-Specific Questionnaire (K-UCSQ) score for an individual; and a step for determining an inflammatory bowel disease prognosis for the individual on the basis of the received K-UCSQ score.

IPC Classes  ?

• G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
• G16H 10/20 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for electronic clinical trials or questionnaires
• G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records

Abstract

The present application provides an assistive device for scalp suturing that allows the hair apposition technique (HAT) procedure to be easily performed even by a single operator. The assistive device for scalp suturing includes: a housing including a frame formed in a circular or polygonal shape having a slot therein and a mounting groove formed on at least some areas of the frame, wherein the slot is positioned at a scalp laceration site; a plurality of knot holes provided on at least some areas of an outer side of the housing; and one or more hair fixers detachably mounted on the mounting groove of the housing and configured to fix hair around the scalp laceration site.

IPC Classes  ?

• A61B 17/04 - Surgical instruments, devices or methods for closing wounds or holding wounds closedAccessories for use therewith for suturing woundsHolders or packages for needles or suture materials

Abstract

A method for modifying a face of a counterpart by using a device for modifying a face of a counterpart according to an embodiment includes the steps of: determining state information corresponding to biometric information of a user; modifying a face image of a counterpart according to the determined state information; and providing the modified face image of the counterpart.

IPC Classes  ?

• G16H 20/70 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to mental therapies, e.g. psychological therapy or autogenous training
• G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
• A61B 5/16 - Devices for psychotechnicsTesting reaction times
• G06V 40/16 - Human faces, e.g. facial parts, sketches or expressions
• G06T 3/4046 - Scaling of whole images or parts thereof, e.g. expanding or contracting using neural networks

Abstract

The present invention relates to a biomarker for diagnosing or predicting prognosis of cerebral infarction, and a use thereof and, more specifically, to: a marker composition for diagnosing or predicting the prognosis of cerebral infarction, comprising miR-93-5p; a composition for diagnosing or predicting prognosis of cerebral infarction, comprising an agent for measuring the level of miR-93-5p; a kit comprising the composition; and method for providing information for diagnosing or predicting the prognosis of cerebral infarction. The biomarker according to the present invention can effectively diagnose the risk of recurrence and the occurrence of cerebral infarction, which has not been efficiently and accurately diagnosed, and can be effectively used for efficient treatment and management.

IPC Classes  ?

• C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material

Abstract

Disclosed are a device and method for estimating bio-age according to an embodiment. The device for estimating bio-age according to an embodiment comprises: one or more processors; and one or more memories storing instructions executed by the one or more processors. The one or more processors are configured to: extract one or more biomarkers by inputting input data including bio-signals of a user to a first model; and estimate the bio-age of the user on the basis of a second model modeled by using the one or more biomarkers.

IPC Classes  ?

• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 5/346 - Analysis of electrocardiograms
• G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
• G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
• G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
• G16H 15/00 - ICT specially adapted for medical reports, e.g. generation or transmission thereof
• G06N 3/045 - Combinations of networks
• G06N 3/0464 - Convolutional networks [CNN, ConvNet]

Abstract

Embodiments provide a method and a system for diagnosing multi-organ cancer by using medical images, the method comprising the steps of: receiving medical images of multiple organs; generating a plurality of region-of-interest images by pre-processing the medical images; and classifying whether cancer is present or not from the plurality of region-of-interest images by using a multi-task multiple instance learning (MT-MIL) model.

IPC Classes  ?

• G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
• G16H 30/20 - ICT specially adapted for the handling or processing of medical images for handling medical images, e.g. DICOM, HL7 or PACS
• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
• G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
• G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
• G06V 10/762 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using clustering, e.g. of similar faces in social networks
• G06V 10/46 - Descriptors for shape, contour or point-related descriptors, e.g. scale invariant feature transform [SIFT] or bags of words [BoW]Salient regional features
• G06V 20/69 - Microscopic objects, e.g. biological cells or cellular parts
• G06T 7/00 - Image analysis

Abstract

The present invention relates to biomarkers for predicting drug treatment responsiveness in bipolar disorder and use thereof. In the present invention, protein markers in blood, showing differences in expression level between treatment responsive and non-responsive groups according to degrees of drug treatment response in bipolar disorder patients, have been discovered, and by quantifying proteins through a multiple reaction detection method, desired proteins can be quantified with high sensitivity without using antibodies. Therefore, the blood-derived protein markers according to the present invention are expected to be useful for predicting drug treatment responsiveness of bipolar disorder patients or predicting the prognosis of bipolar disorder patients treated with drugs.

IPC Classes  ?

• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
• C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material

Abstract

Disclosed are an artificial intelligence-based server for managing patients by underlying disease using medical records, and a method therefor. A patient management server, according to one embodiment of the present invention, comprises: a memory; and a processor for managing information of a patient on the basis of initial data of the patient, wherein the processor: collects the initial data including medical records and performs pre-processing on the initial data, the pre-processing being performed according to pre-processing criteria including text processing and text data vectorization on the initial data; performs training processing by inputting the pre-processed initial data into a pre-trained artificial intelligence model so as to obtain at least one of classification by underlying disease for the patient, precautions for medical treatment, and whether or not an interdepartmental consultation is necessary; and provides training processing results including the at least one of classification by underlying disease for the patient, precautions for medical treatment, and whether or not an interdepartmental consultation is necessary.

IPC Classes  ?

• G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
• G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
• G16H 40/20 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the management or administration of healthcare resources or facilities, e.g. managing hospital staff or surgery rooms
• G16H 10/20 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for electronic clinical trials or questionnaires
• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
• G16H 70/20 - ICT specially adapted for the handling or processing of medical references relating to practices or guidelines
• G06F 18/10 - Pre-processingData cleansing
• G06F 18/241 - Classification techniques relating to the classification model, e.g. parametric or non-parametric approaches
• G06F 40/279 - Recognition of textual entities
• G06F 40/268 - Morphological analysis

Abstract

The present specification provides a glomerulus-on-a-chip, a method for producing same, and a method for screening for a therapeutic agent for renal diseases, using same. In one aspect, a three-dimensional microfluidic glomerulus-on-a-chip of the present invention can effectively reproduce a major microenvironment in vivo, can be used to develop a kidney disease model, and can rapidly and accurately predict an evaluation of the efficacy and toxicity of therapeutic agents for renal diseases.

IPC Classes  ?

• C12M 3/00 - Tissue, human, animal or plant cell, or virus culture apparatus
• C12M 3/06 - Tissue, human, animal or plant cell, or virus culture apparatus with filtration, ultrafiltration, inverse osmosis or dialysis means
• C12M 1/00 - Apparatus for enzymology or microbiology
• C12M 1/12 - Apparatus for enzymology or microbiology with sterilisation, filtration, or dialysis means
• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing

Abstract

The present invention relates to an angiopoietin-1 fusion protein and a use thereof. The novel angiopoietin-1 fusion protein according to the present invention is structurally stable, and can enhance the vascular regenerative capability of peripheral blood stem cells, thereby promoting angiogenesis and vascular maturation. Therefore, the protein is expected to be effectively utilized for the development of therapeutic agents for ischemic diseases.

IPC Classes  ?

• C07K 14/515 - Angiogenic factorAngiogenin
• A61K 38/00 - Medicinal preparations containing peptides

Abstract

Provided is a brain wave activation device enabling the improving of cognitive ability in the elderly by using flickering light stimulation (FLS) of visible light. The brain wave activation device modulates the luminance intensity, color, or flicker frequency of FLS according to user so that the greatest change in the power of brain waves is exhibited in response to the FLS, wherein the flicker frequency of the FLS is outputted so as to be reduced as the age of the user increases.

IPC Classes  ?

• A61M 21/00 - Other devices or methods to cause a change in the state of consciousnessDevices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis
• A61N 5/06 - Radiation therapy using light

Abstract

According to an embodiment, provided is a method of estimating a gait speed, the method including: determining N subjects for gait speed measurement and obtaining personal data of the subjects; performing a clinical assessment on the subjects; obtaining measured gait data by performing a gait assessment on the subjects; and developing a gait speed estimation model having a plurality of gait factors based on the measured gait data, wherein the gait speed estimation model includes, as gait factors, a roll angle, a yaw angle, and a body weight measured by using an accelerometer worn on a center of body mass of the subject.

IPC Classes  ?

• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 5/11 - Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb

Abstract

The present disclosure relates to a novel peptide derivative, etc., the peptide derivative being a partially modified adiponectin receptor peptide which, compared to conventional adiponectin receptor peptides, has higher stability, superior p-AMPK activity, and improved physical properties and activity and thus offers advantages when formulated into a drug. Therefore, the peptide derivative of the present invention can be used to prevent or treat inflammatory skin diseases, wounds, hair loss, fibrosis, metabolic diseases, or cancer, to prevent or alleviate aging, sensitive skin, or wrinkles, or to enhance moisturization.

IPC Classes  ?

• A61K 38/22 - Hormones
• C07K 14/575 - Hormones

Abstract

The present invention relates to a novel peptoid derivative and the like. The peptoid derivative is obtained by partially modifying an adiponectin receptor peptide, and has high stability and excellent p-AMPK activity, compared to existing adiponectin receptor peptides and has improved physical properties and activity, thus having the advantage of being suitable for drug formulation. Therefore, the peptoid derivative of the present invention can be used for the prevention or treatment of skin inflammatory diseases, wounds, hair loss, fibrosis, metabolic diseases, or cancer, or the prevention or amelioration of aging, sensitive skin, wrinkles, or moisturization.

IPC Classes  ?

• C07K 7/06 - Linear peptides containing only normal peptide links having 5 to 11 amino acids
• A61K 8/64 - ProteinsPeptidesDerivatives or degradation products thereof
• A61K 38/00 - Medicinal preparations containing peptides
• A61P 3/04 - AnorexiantsAntiobesity agents
• A61P 17/14 - Drugs for dermatological disorders for baldness or alopecia
• A61Q 7/00 - Preparations for affecting hair growth
• A61Q 19/08 - Anti-ageing preparations

Abstract

Provided are an aqueous humor drainage device capable of preventing low intraocular pressure by reducing the effective inner diameter of an aqueous drainage path even when a tube having a large inner diameter is used, and a manufacturing method thereof. The aqueous humor drainage device comprises: a first tube having a first end portion and a second end portion at both opened ends thereof, allowing aqueous humor to be introduced into the anterior chamber of the eyeball via the first end portion, and discharging the introduced aqueous humor to a subconjunctival space or the outside via the second end portion; and a second tube having a third end portion and a fourth end portion at both open ends thereof and coupled to the inner circumferential surface of the first tube. Here, the third end portion is disposed between the first end portion and the second end portion, the fourth end portion is disposed to overlap the second end portion, and the first tube and the second tube are integrally formed by being made of the same material.

IPC Classes  ?

• A61F 9/007 - Methods or devices for eye surgery
• A61B 17/06 - NeedlesHolders or packages for needles or suture materials
• A61F 9/008 - Methods or devices for eye surgery using laser

Abstract

The present invention relates to: an organ-on-a-chip for mimicking kidney tissue in which renal tubular epithelial cells and renal fibroblasts are co-cultured; a method for manufacturing the organ-on-a-chip; a device for co-culturing three types of cells; and a method for screening for renal fibrosis therapeutic agents by using the organ-on-a-chip. A kidney-on-a-chip according to one embodiment of the present invention has the excellent effects of enabling the time and errors required in screening for renal fibrosis therapeutic agents to be minimized and renal fibrosis therapeutic agents to be more conveniently and simply screened for through an objective evaluation index.

IPC Classes  ?

• C12N 5/071 - Vertebrate cells or tissues, e.g. human cells or tissues
• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing

Abstract

This resistance plate detector for reading positive and negative signals with differential amplifiers, respectively, includes: a plurality of first positive (+) signal strips formed in a strip shape extending in a first direction on a first surface of a first substrate and arranged in parallel to each other; a plurality of first negative (-) signal strips formed in the same shape as the first positive signal strips on a second surface opposite to the first surface of the first substrate, facing each corresponding first positive signal strip in pairs, and arranged in parallel to each other in the first direction; and a plurality of first ground strips formed in the same shape between the plurality of first positive signal strips and the plurality of first negative signal strips and arranged in parallel to each other in the first direction, wherein output signals of a pair of a first positive signal strip and a first negative signal strip, which correspond to each other, are input to one differential amplifier. In the present invention, the ground strips have a rectangular shape or a modified shape thereof, like the signal strips, thus reducing noise of the resistance plate detector to thereby improve performance.

IPC Classes  ?

• G01T 1/29 - Measurement performed on radiation beams, e.g. position or section of the beamMeasurement of spatial distribution of radiation
• G01T 1/26 - Measuring radiation intensity with resistance detectors
• G01T 1/166 - Scintigraphy involving relative movement between detector and subject
• A61B 6/03 - Computed tomography [CT]

Abstract

Disclosed is a portable bio-signal measuring device including a pen-shaped main body, according to an embodiment of the present invention. The portable bio-signal measuring device including a pen-shaped main body, according to an embodiment of the present invention, comprises: a first electrode which is located in a first region of the main body and measures a first potential of a subject when in contact with a first body part of the subject; a second electrode which is located in a second region of the main body and measures a second potential of the subject when in contact with a second body part of the subject; and one or more processors for calculating an electrocardiogram signal of the subject on the basis of the first potential and the second potential.

IPC Classes  ?

• A61B 5/28 - Bioelectric electrodes therefor specially adapted for particular uses for electrocardiography [ECG]
• A61B 5/024 - Measuring pulse rate or heart rate
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 5/352 - Detecting R peaks, e.g. for synchronising diagnostic apparatusEstimating R-R interval
• A61B 5/021 - Measuring pressure in heart or blood vessels

Abstract

The present invention provides a composition for differential diagnosis of urothelial papilloma, and an information provision method using same. By using the composition and the information provision method of the present invention, urothelial papilloma can be distinguished from low-grade urothelial carcinoma, which had been difficult to distinguish by tumor morphological shape in a conventional histopathological examination.

IPC Classes  ?

• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
• C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material