The present invention relates to a system for low-temperature storage of a pharmaceutical composition. The invention also relates to a liquid composition, a method and uses.
B65B 3/00 - Packaging plastic material, semiliquids, liquids or mixed solids and liquids, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans or jars
2.
SYSTEM FOR LONG TIME STORAGE OF PHARMACEUTICAL COMPOSITIONS AT LOW TEMPERATURES
Herein a system comprising a container (1), a stopper (2) and a holding element (3) for long time storage of pharmaceutical compositions at low temperature is described. The system shows superior behavior especially at low temperature.
The invention relates to a securing clamp for glass tubes for machines which can be loaded with glass tubes for producing glass containers, comprising: a central loading channel (52) for the glass tubes; a plurality of adjustable clamping jaws (4) which are arranged at the lower end of the loading channel and distributed around the opening thereof, the distance of the clamping jaws to the centre line of the loading channel being adjustable; an actuating element (1) for jointly adjusting the clamping jaws; a coupling device which couples the adjustable clamping jaws (4) to the actuating element (1); and guides (21) to guide an adjustment motion of the clamping jaws perpendicularly and radially inwards with respect to the centre line of the loading channel (52). According to the invention, the coupling device comprises levers (3) which are each connected in an articulated manner to the actuating element (1) and an allocated clamping jaw (4). The levers and their limb lengths provide parameters with which a characteristic of the clamping force of the securing clamp can be suitably adjusted for a wide range of diameters of glass tubes. The coupling device preferably continuously reduces a ratio between a radially acting clamping force of the clamping jaws and an elastic return force of the springs with decreasing opening width of the clamping jaws.
The invention relates to a positioning device (36) for a preloading ring (34) of a hot-forming machine (1), comprising a first retaining element (58) with a recess (72, 74), and a second retaining element (60), which is arranged in the region of the recess (72, 74) and faces the recess (72, 74), wherein the retaining elements (58, 60) are arranged movably relative to one another in such a way that, by means of a movement of the retaining elements (58, 60) relative to one another, a glass tube (2) can be grasped in the recess (72, 74) and between the retaining elements (58, 60), wherein the positioning device (36) is formed as a retaining clip (36), wherein the retaining elements (58, 60) are formed as limbs (58, 60) of the retaining clip (36), and wherein the limbs (58, 60) move about respective axes (62, 64) in a manner that can be adapted in a technically particularly simple and rapid manner for different glass tube diameters. To this end, each limb (58, 60) comprises a second recess (74, 78), which is distanced radially from the first recess (72, 76) in relation to the axis and is arranged in such a way that, as a result of the movement of the retaining elements (58, 60) relative to one another, a second glass tube (2) can be grasped in the second recess (74, 78) and between the retaining elements (58, 60).
The invention discloses a device for continuously thermally treating pharmaceutical glass containers (2), having a housing (60, 61), in which a continuous conveying gap (5) is formed between an entry region (3) and an exit region (4), a conveying apparatus (6), which is designed such that the glass containers (2) rest without touching one another on a surface of a driven conveying means of the conveying apparatus and are continuously conveyed from the entry region (3) to the exit region (4), a heating zone (11), which is designed such that the glass containers are heated to a maximum temperature in the heating zone (11) when passing through the conveying gap, and a first cooling zone (12) which, viewed in the conveying direction (x), is directly connected to the heating zone (11) and is designed such that the glass containers cool at a first cooling rate in the first cooling zone (12) when passing through the conveying gap. According to the invention, a separating plate (20, 25, 30, 43) is provided at least above the conveying apparatus (6), said separating plate being able to be inductively heated. According to the invention, the temperature conditions can therefore easily be kept more uniform. At the same time, impurities are prevented from entering the glass containers.
C03B 25/06 - Annealing glass products in a continuous way with horizontal displacement of the glass products
C03B 29/06 - Reheating glass products for softening or fusing their surfacesFire-polishingFusing of margins in a continuous way with horizontal displacement of the products
6.
METHOD AND DEVICE FOR THE HOT FORMING OF GLASS CONTAINERS
In a method for integrally forming end portions on glass containers (5) for storing pharmaceutical active compounds, which are produced by hot forming from a glass tube (14), an end portion (8) having an opening, in particular a neck having a neck opening, is formed at one end of the glass containers by hot forming and interaction of a centrally arranged opening/shaping tool (40) with at least one moulding tool (50). In the method, dimension data are provided for each particular glass tube (14) and the position of the at least one moulding tool (50) is adjusted by a motor in an axial direction (z) of the glass containers in response to the provided dimension data for the particular glass tube (14). As a result, fluctuations in the glass volume of the glass tube to be processed are compensated in the region of the hot forming.
The invention relates to a hot-forming device for producing glass containers from a glass tube, comprising a rotary table (12, 23) mounted in a rotatably movable manner and an associated drive motor (21, 41) for driving the rotary table (12, 32), a plurality of holding chucks (16, 36) for holding workpieces (60, 61) being arranged in a distributed manner around the periphery of the rotary table (12, 32). According to the invention, a coolant channel (126, 127, 136) is embodied in the rotary table (12, 32), said coolant channel being liquid-tight and containing a coolant that flows therethrough for cooling the rotary table (12, 32). The cooling enables the easy provision of stable thermal conditions in the region of the rotary table, particularly in sections of the rotary table with high heat input. This can be achieved only a short time after a start-up or a temporary interruption of the hot-forming device. As a result of the constant thermal conditions, the production yield and operating time can be significantly increased.
The invention relates to a hot forming tool (1) for producing glass containers, comprising a forming roller (2) having a forming surface (11), a holder (3) for holding the forming roller (2), and a heat sink (4), which is connected directly or indirectly to the holder (3), wherein the forming roller (2) is rotatably mounted on the holder (3), the forming roller (2) is in thermal contact with the heat sink (4) and the heat sink (4) has means for internal cooling such that process heat can be led away from the forming roller (2) to the heat sink (4).
The invention relates to a syringe (1) having a syringe body (2) with a cylindrical section (3) and a cone-shaped section (4) connected thereto, a luer-lock-connector (10) which comprises a luer collar (11) having an inner thread (12) and a luer cone (15) having a through channel (19). The syringe body (2) and the luer lock connector (10) are designed as a single piece and are made from a cyclic olefin resin, the luer collar (11) has reinforcing ribs (18) on its outer side.
A61M 5/34 - Constructions for connecting the needle
10.
HOLDING STRUCTURE FOR SIMULTANEOUSLY HOLDING A PLURALITY OF CONTAINERS FOR SUBSTANCES FOR PHARMACEUTICAL, MEDICAL OR COSMETIC USES, TRANSPORT STRUCTURE AND TRANSPORTING OR PACKAGING CONTAINER HAVING SAME
The invention relates to a holding structure for simultaneously holding a plurality of containers (50, 51) for substances for pharmaceutical, medical or cosmetic uses, with a plurality of seats (5) for receiving the containers at least partially therein, wherein the seats each have an open upper end for insertion of the containers into the seats and a lower end with a holding portion (12, 22) in order to limit the axial mobility of the containers in the seats, and guide portions are provided in order to guide the containers during their insertion into the seats. The guide portions are configured as guide ribs (18, 25) which extend in the longitudinal direction of the seats, wherein insertion bevels (19, 26) are formed at the upper ends of the guide ribs (18, 25) and are inclined relative to the guide ribs (18, 25). The containers can be held with a relatively close fit by the guide ribs of the seats, and yet at the same time they are able to easily slide into the seats.
A61M 5/00 - Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular wayAccessories therefor, e.g. filling or cleaning devices, arm rests
HOLDING STRUCTURE FOR HOLDING A PLURALITY OF CONTAINERS FOR PHARMACEUTICAL, MEDICAL, OR COSMETIC PURPOSES, AND TRANSPORT OR PACKAGING CONTAINER HAVING SAME
The invention relates to a carrier of a holding structure for holding a plurality of containers for pharmaceutical, medical or cosmetic purposes, in which carrier openings or receptacles (13) for accommodating the containers are formed. Holding means (26; 27; 70) for holding the containers are provided at the openings or receptacles. The holdings means (26; 27; 70) can selectively assume two different, stable positions, namely a first stable position, in which the containers can be inserted into the openings or receptacles (13) without friction, and a second stable position, in which the containers are held in the respective openings or receptacles (13) by frictional or interlocking connection. The containers can be reliably inserted into the openings or receptacles without material abrasion. In the opened insertion position of the holding means, a large number of containers can be simultaneously inserted into the openings or receptacles without large forces acting on the holding structure for this purpose. Furthermore, possible deformation or twisting of the holding structure during use can be considerably reduced according to the invention.
B65D 5/50 - Internal supporting or protecting elements for contents
B65D 71/62 - Tray-like packaging elements provided with handles for storage or transport of a plurality of articles formed by folding one blank into a tubular element, having upper wall portions provided with openings, through which the articles extend with parts of the walls bent against one another to form a longitudinal partition between two rows of articles
B65D 71/64 - Tray-like packaging elements provided with handles for storage or transport of a plurality of articles formed by folding one blank into a tubular element, having upper wall portions provided with openings, through which the articles extend with walls enclosing the articles almost completely
B65D 81/38 - Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents with thermal insulation
The present invention relates to a method and a device for the optical examination of bodies, preferably of transparent bodies made from plastic, glass or glass ceramic. The examination is carried out by means of a contactless detection and measurement of the body, wherein optical image sensors are used. In this case, several individual images are taken from the body during the examination in different positions relative to the image sensor, which are subsequently analyzed.
G01B 11/24 - Measuring arrangements characterised by the use of optical techniques for measuring contours or curvatures
G01N 21/90 - Investigating the presence of flaws, defects or contamination in a container or its contents
13.
TRANSPORT FORMATION FOR A PLURALITY OF BOTTLES FOR PHARMACEUTICAL, MEDICAL OR COSMETIC PURPOSES, STERILE PACKAGING STRUCTURE, AND METHOD FOR PROCESSING BOTTLES
A transport formation 1 for receiving a plurality of bottles 60 for pharmaceutical, medical or cosmetic purposes under non-sterile conditions is composed of a receiving part 10 and of a bearing part 30 connected releasably to the latter, wherein the receiving part 10 has a plurality of frustoconical receivers 14 in a regular arrangement, such that the bottles 60 can be received, in the receivers of the receiving part, in an upright position and without direct contact between adjacent bottles. The transport formation has locking formations 21, 23 for releasably locking the receiving part to the bearing part. According to the invention, the receivers 14 are adapted to the height of the bottles such that the bottles 60 can be received fully inside the latter, wherein the bearing part 30 is composed of a base plate 31 with a flat bearing surface facing towards the receivers, such that, after the locking has been released, the bottles 60 can be moved freely on the bearing surface of the base plate 31 and, by displacement of the receiving part 10 relative to the bearing part 30, can be pushed by the bearing part. Receiving part and/or bearing part can be designed cost-effectively in one piece by thermoforming of a plastic, in particular by thermoforming of a thin film or a thin-film sheet.
B65B 3/00 - Packaging plastic material, semiliquids, liquids or mixed solids and liquids, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans or jars
B65D 85/00 - Containers, packaging elements or packages, specially adapted for particular articles or materials
14.
CLOSURE SYSTEM, IN PARTICULAR A SYRINGE CLOSURE SYSTEM FOR SEALINGLY CLOSING A DISTAL OPENING OF A SYRINGE BODY, AND SYRINGE WITH A CLOSURE SYSTEM
The invention relates to a closure system, in particular a syringe closure system for sealingly closing a distal opening, for example a syringe cone of a syringe body, wherein the closure system, in particular the syringe closure system for sealingly closing the distal opening, for example the syringe cone, comprises a closure cap, characterized in that the closure cap comprises a hard area and an elastomer part, wherein the elastomer part is configured in such a way that it sealingly closes the distal opening by substantially axial pressure, in particular only by being placed on and/or only by enclosing a short portion in the area of a tip of the distal opening; the closure cap furthermore comprises a sleeve, in particular a thin-walled sleeve, and at least one connection point or at least one connection surface, wherein the at least one connection point or the at least one connection surface is configured in such a way that an integrally bonded connection to the hard area is formed, wherein the integrally bonded connection extends in an axial direction of the sleeve; and the at least one connection point or the at least one connection surface and the thin-walled sleeve are designed in such a way that the integrally bonded connection between thin-walled sleeve and hard area can be undone by a radial deformation of the thin-walled sleeve.
The invention relates to a closure piece, in particular a syringe closure piece for closing a distal opening (4) of a syringe cone of a syringe body, for example, in a sealed manner, wherein the closure piece, in particular the syringe closure piece, comprises a fastening element (3) which is or can be arranged on the syringe body about the distal opening, in particular on the syringe cone, and which is in particular a Luer lock or a Luer lock adapter (3.1), and a closure cap (20) which closes the distal opening, for example the syringe cone, in a sealed manner and which is connected releasably to the fastening element. The invention is characterized in that the closure cap, in the area of the fastening element, is connected by material bonding, preferably exclusively by material bonding, to the fastening element, in particular to the Luer lock or the Luer lock adapter, by at least one connection point or one connection surface, and the closure cap comprises a hard area (30) and an elastomer part (10), wherein the elastomer part securely closes the distal opening in particular by simply being placed on or enclosing a short portion in the area of a tip of the distal opening.
A61M 5/50 - Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular wayAccessories therefor, e.g. filling or cleaning devices, arm rests having means for preventing re-use, or for indicating if defective, used, tampered with or unsterile
A61M 39/20 - Closure caps or plugs for connectors or open ends of tubes
A61M 5/32 - NeedlesDetails of needles pertaining to their connection with syringe or hubAccessories for bringing the needle into, or holding the needle on, the bodyDevices for protection of needles
The invention relates to a closure, particularly a syringe cap (1) for closing in a sealing manner a distal opening (4), such as a syringe cone on a syringe body (3), wherein the closure, particularly the syringe cap, comprises a fastening element (32) that is or can be arranged on the syringe body around the distal opening, particularly around the syringe cone, and a closure cap (7) that can be loosely connected to the fastening element and closing in a sealing manner the distal opening, such as a syringe cone; the invention is characterised in that the fastening element (32) comprises an inner thread (30) that intermeshes with an outer thread (22) on the closure cap (7), resulting in an initial state wherein the outer thread is formed on at least part of the closure cap, wherein said part is under tension in such a way that after the closure cap is unscrewed from the inner thread the part under tension is pressed out over the inner thread of the fastening element such that the closure cap cannot be returned to the initial state once the closure cap is unscrewed.
A61M 5/50 - Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular wayAccessories therefor, e.g. filling or cleaning devices, arm rests having means for preventing re-use, or for indicating if defective, used, tampered with or unsterile
A61M 39/20 - Closure caps or plugs for connectors or open ends of tubes
A61M 5/32 - NeedlesDetails of needles pertaining to their connection with syringe or hubAccessories for bringing the needle into, or holding the needle on, the bodyDevices for protection of needles
The invention relates to a carrier plate for pharmaceutical containers, in particular syringes, bottles, or ampoules, comprising a receiving region that has a plurality of through-openings for receiving the pharmaceutical containers, comprising a handling region that defines a base plane for handling the carrier plate, in particular for engaging on the carrier plate and/or for supporting same, comprising a top face that functions as a pressure side under a load, comprising a lower face that functions as a tension side, and comprising means for increasing the rigidity of the carrier plate. The invention is characterized in that the means for increasing the rigidity comprise at least one box profiled region between at least two through-openings on the upper face of the carrier plate. The invention further relates to a transporting and/or storing device for pharmaceutical containers, in particular syringes, bottles, or ampoules, comprising such a carrier plate.
A61M 5/00 - Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular wayAccessories therefor, e.g. filling or cleaning devices, arm rests
patents