The invention relates to an industrially applicable device for reading out a test kit for detecting biomarkers, e.g. for detecting biomarkers in human and/or animal stool. The device is designed and intended for objectifying the qualitative and/or quantitative detection of the biomarkers. In particular, the invention relates to a device in which a test strip of an immunochromatographic detection method is inserted in a fixed manner. The test strip is illuminated by more defined illumination devices and the light reflected from the surface of the quick test strip is recorded by a more specific sensor. A precise read-out of the displayed test result takes place using a special illumination and read-out method.
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Pharmaceutical products, namely, diagnostic kits consisting primarily of monoclonal antibodies, buffers, and reagents for use in disease testing for colon cancer
The invention relates to a novel bioanalysis device for selected biological analytes, containing a) a carrier layer, b) a functional layer and c) optionally a capping layer, wherein the functional layer can hold and transport liquid and has a capture molecule for the selected analyte at at least one point, characterized in that the carrier layer and/or the capping layer contain sensor elements for the selected analyte, which sensor elements in turn were introduced by printing methods onto or into the carrier layer and/or the capping layer, and to a method for detecting bioanalytes by means of the device according to the invention.
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Diagnostic preparations.
20.
Test kit (combined quick test) for the synchronous proof of biomarkers in faeces for detecting of pathological changes in the gastrointestinal tract, particularly in the intestine
The invention relates to a test kit for better carrying out a method for detecting biomarkers in human or animal stool, which can serve as an indication of a pathological, particularly a malignant event in the gastrointestinal tract (esophagus, stomach, small bowel, biliary tract, pancreas, and bowel).
The invention teaches a novel and more efficient methods, uses and embodiments of a combined rapid test. The combined rapid test cassette used for implementing the test kit and the optimally coordinated reagents thereof contains two lateral flow test strips for the synchronous—in the technical meaning—detection of the biomarkers M2-PK and the biomarker hemoglobin.
The test serves as a “dual filter” for diagnosing probands as part of a colon cancer screening program. The test is very cost-efficient and cuts costs in the health system by the examination at an early stage of colon cancer and the consequences thereof.
05 - Pharmaceutical, veterinary and sanitary products
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Pharmaceutical and veterinary preparations, in particular
compositions for diagnostic purposes. Scientific and technological services and research;
industrial analysis and research services. Medical services and veterinary services; hygienic care for
human beings and animals.
05 - Pharmaceutical, veterinary and sanitary products
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Pharmaceutical and veterinary preparations, in particular diagnostic compositions. Scientific and technological services and research services; Industrial analysis and research services. Medical services; Hygienic care for human beings or animals.
28.
TEST KIT (COMBI-QUICK TEST) FOR THE SYNCHRONOUS PROOF OF BIOMARKERS IN FAECES FOR DETECTING PATHOLOGICAL CHANGES IN THE GASTROINTESTINAL TRACT, PARTICULARLY IN THE INTESTINE
The invention relates to a test kit for improving the performance of a method for proving biomarkers in human or animal faeces, which can serve as an indication of a pathological, particularly a malign occurrence in the gastrointestinal tract (oesophagus, stomach, small intestine, biliary tract, pancreas and large intestine). The invention teaches and describes methods, as well as the use and the embodiments of a combi-quick test which is novel and more efficient with respect to the prior art. The combi-quick test cartridge used to execute the test kit and the optimally-matched reagents thereof contains 2 lateral flow test strips, which are novel and more efficient with respect to the prior art, for the synchronous - in the technical sense - proof of the M2-PK biomarker and the haemoglobin biomarker. The test serves as a "double filter" for diagnosing probands as part of an intestinal cancer screening programme (intestinal cancer early detection examination). The positive diagnosis of an M2-PK and/or haemoglobin biomarker prompts a coloscopy for the purposes of further diagnosis by the physician. The test is very cost-efficient and cuts costs in the health system by detecting intestinal cancer and the consequences thereof at an early stage. The test result is preferably shown in the form of various colours, letters, numerals and/or geometric figures.
05 - Pharmaceutical, veterinary and sanitary products
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Pharmaceutical and veterinary preparations, in particular diagnostic compositions. Scientific and technological services and research; Industrial analysis and research services. Medical services; Hygienic care for human beings or animals.
05 - Pharmaceutical, veterinary and sanitary products
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Pharmaceutical and veterinary preparations, in particular diagnostic compositions. Scientific and technological services and research; industrial analysis and research services. Medical services; Hygienic care for human beings or animals.
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Scientific and technological services and research, namely, pharmaceutical research and development; industrial analysis and research services, namely, industrial research in the field of pharmaceuticals Medical and veterinary services; health care services for humans and animals
The present patent application relates to a method for determining the biomarker L-PK in the faeces for detecting a liver disease, in particular a tumour.
C12Q 1/48 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving transferase
05 - Pharmaceutical, veterinary and sanitary products
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Pharmaceutical and veterinary preparations, in particular diagnostic compositions. Scientific and technological services and research; industrial analysis and research services. Medical services; Hygienic care for human beings or animals.
The present invention relates to novel pharmaceuticals based on novel substituted 4-pyridine-3yl-pyrimidine, to a method for the production thereof, and to the use thereof in medical therapy, in particular cancer diseases.
C07D 401/04 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring- member bond
C07D 401/14 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
A61K 31/506 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
The invention relates to compounds of general formula (I) with -C-O-N- or -C-N-O- groups (for example -C-O-N(H)-C(=O)- or -C-N(H)-O-C(=O)-), to methods for the production thereof, and to the use of same in medical treatment, especially for cancerous diseases.
A61K 31/517 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
C07D 401/12 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
C07D 403/12 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a chain containing hetero atoms as chain links
C07D 405/04 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring- member bond
38.
OXAZOLIDINONES AS FACTOR XA INHIBITORS, METHODS FOR THE PRODUCTION THEREOF, AND USE THEREOF IN THERAPY
The application relates to novel pharmaceuticals of formula (I), methods for the production thereof, and the use thereof in medical therapy, for example in the field of coagulation. In said formula (I), Z1, Z2, Z3, and Z4 independently represent a direct bond, an oxygen atom, or a sulfur atom, R2 represents a hydrogen atom or a branched or straight C1-C4 alkyl group, R4 represents -Cl -F, -Br, -CF3, or -OCF3, -NO2, or -OCH3, and n represents one of the integers 0, 1, 2, 3, or 4.
C07D 413/14 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
A61K 31/5377 - 1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
The present patent application relates to novel pharmaceuticals based on novel substituted compounds of formula I, and to the use thereof in medical therapy, particularly for cancer diseases, the effect of which is possibly as a result of the inhibition of aromatases.
The application relates to compounds of general formula (I) Ar-[CH2]m-Z1-N(Z2-R2)-Z3-[C(O)]r-[CH2]n-Y1-[C(O)]s-Y2-R1, in which the variables can take the values specified in the application. In particularly preferred individual compounds of formula (I), -Z1-N(Z2-R2)-Z3-[C(O)]r- forms an -O-NH-C(O)- or -NH-O-C(O)- group. Said compounds (I) are suitable as medicaments for the treatment of cancer diseases. The effect thereof is due to histone deacetylase inhibition.
C07D 213/64 - One oxygen atom attached in position 2 or 6
C07C 259/06 - Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
A61K 31/4402 - Non-condensed pyridinesHydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
The invention relates to the compound of formula (I), wherein one of the groups R1-R10 represents a group -ONR11R12 -CH2-ONR11R12, -(CH2)2-ONR11R12, -O(C=O)NR11R12, -CH2-O(C=O)NR11R12, -(CH2)2-O(C=O)NR11R12, -(C=O)-O-NR11R12, -CH2(C=O)-O-NR11R12, -(CH2)2(C=O)-O-NR11R12 or one of the following groups (formulae II - IX) or one of the other groups defined in claim 1, and to the use thereof in the prophylaxis and therapy of CNS diseases and diabetes.
C07C 239/20 - Hydroxylamino compounds or their ethers or esters having oxygen atoms of hydroxylamino groups etherified
C07D 207/16 - Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
A61K 31/40 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
C07D 213/89 - Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
43.
NOVEL INDOL-PYRROL DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE AND INFLAMMATORY DISEASES
The invention relates to novel indol-pyrrol derivatives of formula I which are suitable for the production of pharmaceutical compositions for the prophylaxis and/or treatment of a proliferative or inflammatory disease.
C07D 403/06 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
C07D 261/18 - Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen
C07C 255/20 - Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
Chemicals for analyses in laboratories and chemicals used in
science, enzymes for industrial purposes, enzyme
preparations for industrial purposes, ferments for chemical
purposes. Chemical preparations for medical purposes, diagnostic
preparations for medical purposes, test kits for biological
and medical purposes, enzymes for medical purposes, enzyme
preparations for medical purposes. Apparatus for use in medical analysis.
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
biological test kits comprised primarily of reagents, markers and antibodies for scientific research chemicals, namely, enzymes, antibodies and ferments used in medical diagnostics and biological test kits comprised primarily of reagents, markers and antibodies for medical diagnostic use [ medical apparatus for analyzing for the presence or absence of antigens ]