A method of preparing an implantable biomaterial includes combining a polymer comprising polydioxanone with a neuro-regenerative agent or an immunosuppressive agent comprising at least one immunophilin ligand, and melting the polymer. The method further includes extruding the combined polymer and the neuro-regenerative agent or immunosuppressive agent to form the implantable biomaterial.
A61L 27/36 - Materials for prostheses or for coating prostheses containing ingredients of undetermined constitution or reaction products thereof
A61B 17/11 - Surgical instruments, devices or methods for closing wounds or holding wounds closedAccessories for use therewith for performing anastomosisButtons for anastomosis
A61L 27/18 - Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
A61L 27/54 - Biologically active materials, e.g. therapeutic substances
2.
TISSUE REPAIR MEMBRANE AND METHODS FOR PREPARING THE SAME
Provided herein is a tissue repair matrix modified with a hydrogel polymer to provide adhesion and/or lubrication to assist with the use and implantation of the tissue repair membrane, and to facilitate healing and/or avoid or minimize damage to adjacent, e.g., tissues, during or after implantation.
An adhesive tissue covering may include a base membrane and a biodegradable and biocompatible adhesive configured to bond to tissue. The adhesive may be located along one or more edges of the base membrane. In some aspects, an adhesive tissue strip may include a base membrane formed of at least one of a tissue-based material or a resorbable polymer, and a biodegradable and biocompatible adhesive configured to bond to tissue. The adhesive may be located on one side of the base membrane of the adhesive tissue strip.
A method of preparing a nerve graft includes submerging a nerve graft in a solution including FK506 and a solvent to promote incorporation of FK506 into the nerve graft. A tissue graft includes nerve tissue and FK506 incorporated within the nerve tissue. In the tissue graft, the FK506 is free of hydrogel and not encapsulated.
An adhesive tissue covering may include a base membrane and a biodegradable and biocompatible adhesive configured to bond to tissue. The adhesive may be located along one or more edges of the base membrane. In some aspects, an adhesive tissue strip may include a base membrane formed of at least one of a tissue-based material or a resorbable polymer, and a biodegradable and biocompatible adhesive configured to bond to tissue. The adhesive may be located on one side of the base membrane of the adhesive tissue strip.
Provided herein is a tissue repair matrix modified with a hydrogel polymer to provide adhesion and/or lubrication to assist with the use and implantation of the tissue repair membrane, and to facilitate healing and/or avoid or minimize damage to adjacent, e.g., tissues, during or after implantation.
An electrode apparatus may include a handle, a cannula extending from a distal end of the handle and having at least one lumen, a ground wire extending through the cannula, and an electrode wire extending through the handle and the cannula, the electrode wire being extendable and retractable relative to a distal end of the cannula. The apparatus may also include a hook, provided in the cannula, and being extendable and retractable relative to the cannula.
An electrode apparatus may include a handle, a cannula extending from a distal end of the handle and having at least one lumen, a ground wire extending through the cannula, and an electrode wire extending through the handle and the cannula, the electrode wire being extendable and retractable relative to a distal end of the cannula. The apparatus may also include a hook, provided in the cannula, and being extendable and retractable relative to the cannula.
A capture-tool for manipulation of tissue utilizes vacuum to hold the tissue in place. An extension attached to a vacuum source at one end and a vacuum arm at another end creates a vacuum force through the extension and vacuum arm. The vacuum arm has a support surface with ports therein at which low pressure areas are formed by the vacuum force. The low pressure areas draw tissue against the supporting surface to hold it in place, as long as the vacuum force is active.
A61B 17/30 - Surgical pincettes, i.e. surgical tweezers
A61B 17/11 - Surgical instruments, devices or methods for closing wounds or holding wounds closedAccessories for use therewith for performing anastomosisButtons for anastomosis
A barbed suture may include a body and a plurality of barbs. The body may include a substantially flat surface extending along a longitudinal axis of the body, and the plurality of barbs may be formed on a surface of the body that is not the substantially flat surface. The body may have a non-circular cross-sectional shape, and the plurality of barbs may be formed along a longitudinal axis of the body on a corner of the cross-sectional shape. A tissue repair device may include a base membrane and a plurality of barbed sutures attached to the base membrane.
A device for detecting a temperature above a threshold temperature, the device including a first reservoir and a second reservoir fluidly connected to the first reservoir. When the device is exposed to a temperature at or below the threshold temperature, a material is disposed within the first reservoir. When the device is exposed to a second temperature greater than the threshold temperature, at least a portion of the material is disposed within the second reservoir.
G01K 11/06 - Measuring temperature based on physical or chemical changes not covered by group , , , or using melting, freezing, or softening
G01K 3/04 - Thermometers giving results other than momentary value of temperature giving mean valuesThermometers giving results other than momentary value of temperature giving integrated values in respect of time
12.
MEDICAL DEVICES AND RELATED METHODS FOR DETECTING A CHANGE IN TEMPERATURE
A device for detecting a temperature above a threshold temperature, the device including a first reservoir and a second reservoir fluidly connected to the first reservoir. When the device is exposed to a temperature at or below the threshold temperature, a material is disposed within the first reservoir. When the device is exposed to a second temperature greater than the threshold temperature, at least a portion of the material is disposed within the second reservoir.
A61B 10/02 - Instruments for taking cell samples or for biopsy
A61B 17/11 - Surgical instruments, devices or methods for closing wounds or holding wounds closedAccessories for use therewith for performing anastomosisButtons for anastomosis
A61B 17/30 - Surgical pincettes, i.e. surgical tweezers
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
A61B 17/11 - Surgical instruments, devices or methods for closing wounds or holding wounds closedAccessories for use therewith for performing anastomosisButtons for anastomosis
A61F 2/04 - Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
A61K 35/12 - Materials from mammalsCompositions comprising non-specified tissues or cellsCompositions comprising non-embryonic stem cellsGenetically modified cells
A61B 17/11 - Surgical instruments, devices or methods for closing wounds or holding wounds closedAccessories for use therewith for performing anastomosisButtons for anastomosis
A61F 2/04 - Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
A61K 35/12 - Materials from mammalsCompositions comprising non-specified tissues or cellsCompositions comprising non-embryonic stem cellsGenetically modified cells
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
Biological tissue grafts; Human allograft tissue; Biological tissue intended for subsequent implantation; Surgical implants, namely, nerve implants made of biological tissue; Surgical implants comprising biological tissue; Nerve and tissue grafts and implants comprising biological materials for use in regenerative medicine, wound repair, surgical repair, neurotizing breast reconstruction, and nerve repair and regeneration; biological implants. Surgical implants comprising natural, non-living materials; Surgical implants, namely, nerve implants made of natural, non-living materials; Nervous tissue products for use in regenerative medicine, surgical repair, neurotizing breast reconstruction, and nerve repair and regeneration; Medical and veterinary devices, namely, nerve and tissue grafts and implants comprising natural, non-living materials, for use in regenerative medicine, surgical repair, neurotizing breast reconstruction, and nerve repair and regeneration; Medical implants; Grafts for surgical use; Medicinal products acting on the peripheral or central nervous system.
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
Biological tissue grafts; Human allograft tissue; Biological tissue intended for subsequent implantation; Surgical implants, namely, nerve implants made of biological tissue; Surgical implants comprising biological tissue; Nerve and tissue grafts and implants comprising biological materials for use in regenerative medicine, wound repair, surgical repair, neurotizing breast reconstruction, and nerve repair and regeneration; biological implants. Surgical implants comprising natural, non-living materials; Surgical implants, namely, nerve implants made of natural, non-living materials; Nervous tissue products for use in regenerative medicine, surgical repair, neurotizing breast reconstruction, and nerve repair and regeneration; Medical and veterinary devices, namely, nerve and tissue grafts and implants comprising natural, non-living materials, for use in regenerative medicine, surgical repair, neurotizing breast reconstruction, and nerve repair and regeneration; Medical implants; Grafts for surgical use; Medicinal products acting on the peripheral or central nervous system.
A barbed suture may include a suture body and at least one multi-directional barb formed on an outer surface of the suture body. The at least one multi-directional barb includes a first projection and a second projection, the first projection and the second projection extending in two different directions. In another embodiment, a barbed suture may include a suture body and at least two barbs formed on an outer surface of the suture body. Each of the at least two barbs has a first projection pointing in a first direction, and a second projection pointing in a second direction, the first direction being different than the second direction. The invention also relates to methods of forming barbed sutures.
A barbed suture may include a suture body and at least one multi-directional barb formed on an outer surface of the suture body. The at least one multi-directional barb includes a first projection and a second projection, the first projection and the second projection extending in two different directions. In another embodiment, a barbed suture may include a suture body and at least two barbs formed on an outer surface of the suture body. Each of the at least two barbs has a first projection pointing in a first direction, and a second projection pointing in a second direction, the first direction being different than the second direction. The invention also relates to methods of forming barbed sutures.
Tissue-processing containers are disclosed for facilitating multistep processing of tissue. Also disclosed are systems incorporating the tissue-processing containers that include shakers, incubators, controllers, and pumps. Multistep methods are disclosed for processing tissues using the tissue-processing containers. The tissue-processing containers are specially designed to achieve efficiencies in automated tissue processing, exposure of tissues to processing media, and multistep tissue processing protocols. The described tissue-processing containers comprise a cup-like cavity comprising a middle hole covered by a mesh screen, troughs for separate processing steps, and are stackable in a substantially airtight and substantially watertight manner. Tissues for processing using the described tissue-processing containers include nerve tissue. Also described herein is a transport housing for the transport of stacks of tissue-processing containers, and which may directly incubate those containers, or which may be placed inside a separate incubator for incubating the containers.
The problem of attaching a donor nerve stump to a recipient nerve for an end-to-side coaptation is solved by the use of a tissue connector. The tissue connector can have a body for receiving the donor nerve stump and one or more overflaps for attaching the tissue connector with the donor nerve stump therein to the epineurium on the side of the recipient nerve. Sutures can also be used to secure the tissue connector and nerves in place.
A61B 17/11 - Surgical instruments, devices or methods for closing wounds or holding wounds closedAccessories for use therewith for performing anastomosisButtons for anastomosis
A61B 17/00 - Surgical instruments, devices or methods
A61L 27/16 - Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
A61L 27/18 - Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
A61L 27/36 - Materials for prostheses or for coating prostheses containing ingredients of undetermined constitution or reaction products thereof
The problem of attaching a donor nerve stump to a recipient nerve for an end-to-side coaptation is solved by the use of a tissue connector. The tissue connector can have a body for receiving the donor nerve stump and one or more overflaps for attaching the tissue connector with the donor nerve stump therein to the epineurium on the side of the recipient nerve. Sutures can also be used to secure the tissue connector and nerves in place.
A61B 17/11 - Surgical instruments, devices or methods for closing wounds or holding wounds closedAccessories for use therewith for performing anastomosisButtons for anastomosis
A61B 17/00 - Surgical instruments, devices or methods
A61L 27/16 - Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
A61L 27/18 - Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
A61L 27/36 - Materials for prostheses or for coating prostheses containing ingredients of undetermined constitution or reaction products thereof
Tissue-processing containers are disclosed for facilitating multistep processing of tissue. Also disclosed are systems incorporating the tissue-processing containers that include shakers, incubators, controllers, and pumps. Multistep methods are disclosed for processing tissues using the tissue-processing containers. The tissue-processing containers are specially designed to achieve efficiencies in automated tissue processing, exposure of tissues to processing media, and multistep tissue processing protocols. The described tissue-processing containers comprise a cup-like cavity comprising a middle hole covered by a mesh screen, troughs for separate processing steps, and are stackable in a substantially airtight and substantially watertight manner. Tissues for processing using the described tissue-processing containers include nerve tissue. Also described herein is a transport housing for the transport of stacks of tissue-processing containers, and which may directly incubate those containers, or which may be placed inside a separate incubator for incubating the containers.
The present disclosure pertains to membranous tissue grafts comprising one or more pre-made attachment points. The one or more pre-made attachment points may include pre-made markings and/or pre-made suture holes. The membranous tissue grafts can be in the form of a tube. The membranous tissue grafts can also be rectangular in shape and can be used in a nerve repair by wrapping the severed or damaged nerve. In some embodiments, the membranous tissue grafts are suitable for repairing severed nerves that have a short gap or no gap with a gap of less than 5 mm between the severed stumps. Accordingly, methods are provided for repairing a damaged or severed nerve by implanting the membranous tissue grafts on to the damaged or severed nerve.
A61F 2/00 - Filters implantable into blood vesselsProstheses, i.e. artificial substitutes or replacements for parts of the bodyAppliances for connecting them with the bodyDevices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
The problem of attaching a donor nerve stump to a recipient nerve for an end-to-side coaptation is solved by the use of a tissue connector. The tissue connector can have a body for receiving the donor nerve stump and one or more overflaps for attaching the tissue connector with the donor nerve stump therein to the epineurium on the side of the recipient nerve. Sutures can also be used to secure the tissue connector and nerves in place.
A61B 17/11 - Surgical instruments, devices or methods for closing wounds or holding wounds closedAccessories for use therewith for performing anastomosisButtons for anastomosis
A61B 17/00 - Surgical instruments, devices or methods
A61L 27/16 - Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
A61L 27/18 - Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
A61L 27/36 - Materials for prostheses or for coating prostheses containing ingredients of undetermined constitution or reaction products thereof
Techniques are described for determining the quality of a nerve graft by assessing quantitative structural characteristics of the nerve graft. Aspects of the techniques include obtaining an image identifying laminin-containing tissue in the nerve graft; creating a transformed image using a transformation function of an image processing application on the image; using an analysis function of the image processing application, analyzing the transformed image to identify one or more structures in accordance with one or more recognition criteria; and determining one or more structural characteristics of the nerve graft derived from a measurement of the one or more structures.
Tissue grafts with reduced regenerative potential, methods of preparing such grafts, and related kits and methods of treatment are described. The method may include treating tissue with a digestion solution comprising trypsin, alpha-chymotrypsin (ACT) and optionally ethylenediaminetetraacetic acid (EDTA) to substantially remove one or more susceptible proteins from the tissue. The method may also include washing the treated tissue with a buffer solution and/or with a serine-containing serum. Nerve grafts prepared according to the disclosed methods may inhibit, or lessen (e.g., provide for reduced) neuroma formation and/or axonal outgrowth after implantation.
Tissue grafts with reduced regenerative potential, methods of preparing such grafts, and related kits and methods of treatment are described. The method may include treating tissue with a digestion solution comprising trypsin, alpha-chymotrypsin (ACT) and optionally ethylenediaminetetraacetic acid (EDTA) to substantially remove one or more susceptible proteins from the tissue. The method may also include washing the treated tissue with a buffer solution and/or with a serine-containing serum. Nerve grafts prepared according to the disclosed methods may inhibit, or lessen (e.g., provide for reduced) neuroma formation and/or axonal outgrowth after implantation.
A tissue connector may include a body formed of one or more layers of material, and at least one barbed suture attached to the body, wherein the barbed suture is formed of a biodegradable material. A method of forming a tissue connector may include forming a body from one or more layers of a material, and attaching at least one barbed suture to the body, wherein the barbed suture is formed of a biodegradable material. A method of repairing tissue using a tissue connector may include orienting the tissue connector around coapted or damaged tissue, so that the coapted or damaged tissue contacts the inner surface of the tissue connector, twisting ends of the at least one barbed suture so that the at least one barbed suture engages the coapted or damaged tissue, and allowing the tissue connector to remain in place, so that the barbed suture degrades over time.
A61B 17/06 - NeedlesHolders or packages for needles or suture materials
A61B 17/11 - Surgical instruments, devices or methods for closing wounds or holding wounds closedAccessories for use therewith for performing anastomosisButtons for anastomosis
The invention provides automated methods for analyzing and quantifying the clearance of chondroitin sulfate proteoglycans (CSPGs) from a processed nerve graft tissue sample.
Tissue-processing containers are disclosed for facilitating multistep processing of tissue. Also disclosed are systems incorporating the tissue-processing containers that include shakers, incubators, controllers, and pumps. Multistep methods are disclosed for processing tissues using the tissue-processing containers. The tissue-processing containers are specially designed to achieve efficiencies in automated tissue processing, exposure of tissues to processing media, and multistep tissue processing protocols. The described tissue-processing containers comprise a cup-like cavity comprising a middle hole covered by a mesh screen, troughs for separate processing steps, and are stackable in a substantially airtight and substantially watertight manner. Tissues for processing using the described tissue-processing containers include nerve tissue. Also described herein is a transport housing for the transport of stacks of tissue-processing containers, and which may directly incubate those containers, or which may be placed inside a separate incubator for incubating the containers.
The invention provides automated methods for analyzing and quantifying the clearance of chondroitin sulfate proteoglycans (CSPGs) from a processed nerve graft tissue sample.
A61B 17/11 - Surgical instruments, devices or methods for closing wounds or holding wounds closedAccessories for use therewith for performing anastomosisButtons for anastomosis
The subject invention provides devices and methods for alleviating discomfort associated with neuroma formation. The devices and methods of the invention effectively use the body's natural response of reconstructing implanted biomaterials to minimize the size of, isolate, and protect a neuroma. In preferred embodiments, the subject device is a cylindrical cap, wherein the internal chamber of the cylindrical cap physically partitions the nerve to enable an arrangement of nerve fibers (as opposed to haphazardly arranged nerve fibers often produced in neuromas). Tabs arranged on the outside of the cap can be used to manipulate the cap into place on a nerve. The open end can also be configured with flaps that can be used to widen the open end for easier insertion of the nerve into the cap. In addition, the cap's material remodels into a tissue cushion after implantation, which protects the neuroma from being stimulated and inducing pain.
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
The subject invention provides devices and methods for alleviating discomfort associated with neuroma formation. The devices and methods of the invention effectively use the body's natural response of reconstructing implanted biomaterials to minimize the size of, isolate, and protect a neuroma. In preferred embodiments, the subject device is a cylindrical cap, wherein the internal chamber of the cylindrical cap physically partitions the nerve to enable an arrangement of nerve fibers (as opposed to haphazardly arranged nerve fibers often produced in neuromas). Tabs arranged on the outside of the cap can be used to manipulate the cap into place on a nerve. The open end can also be configured with flaps that can be used to widen the open end for easier insertion of the nerve into the cap. In addition, the cap's material remodels into a tissue cushion after implantation, which protects the neuroma from being stimulated and inducing pain.
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
The invention generally relates to devices for manufacture of tissue products, and, more particularly, to material layering assemblies for processing tissue layers to produce a multi-layered tissue product. The invention provides a material layering system to support and/or hold various layers of material to form a multi-layered product.
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
(1) Implants comprising living tissue; Implants comprising biological tissue and chemical preparations for aiding implantation; Surgical implants comprised of biological tissue, namely, animal tissue for medical and veterinary use; Pharmaceutical and veterinary preparations, and delivery systems therefor sold as a unit, for use in regenerative medicine; Pharmaceutical and veterinary preparations, and delivery systems therefor sold as a unit, for wounds; Pharmaceutical and veterinary preparations, and delivery systems therefor sold as a unit, for tissue repair; Pharmaceutical and veterinary preparations, and delivery systems therefor sold as a unit, for surgical repair; Pharmaceutical and veterinary preparations, and delivery systems therefor sold as a unit, acting on the central or peripheral nervous system; Medical and veterinary instruments and devices, namely, tissue grafts and implants comprising living tissue for use in regenerative medicine, wound repair, tissue repair and regeneration, surgical repair, breast reconstruction, and nerve repair and regeneration; Tissue products for use in regenerative medicine, wound repair, surgical repair, breast reconstruction, and nerve repair and regeneration; Chemical preparations for aiding implantation sold as an integral component of an implant comprising biological tissue
(2) Medical devices, namely, tissue grafts and implants comprising natural, non-living materials, for use in regenerative medicine, wound repair, tissue repair and regeneration, surgical repair, breast reconstruction, and nerve repair and regeneration; Chemical preparations for aiding implantation sold as an integral component of an implant comprising natural, non-living material
44.
METHOD FOR EVALUATING BIOLOGICAL ACTIVITY OF BIOMATERIALS
A method for conducting an in vitro assay of a biomaterial may include freezing a sample of biomaterial and sectioning the frozen sample of biomaterial into at least one section of biomaterial. The at least one section of biomaterial may have a thickness of about 10 μm to about 50 μm. The method may further include placing the at least one section of biomaterial onto a slide; affixing a neuron or a group of neurons to one end portion of the at least one section of biomaterial to create a test construct; incubating the test construct; and determining an amount of neurite growth from the neuron or the group of neurons along the at least one section of biomaterial.
in vitroin vitro assay of a biomaterial may include freezing a sample of biomaterial and sectioning the frozen sample of biomaterial into at least one section of biomaterial. The at least one section of biomaterial may have a thickness of about 10 μm to about 50 μm. The method may further include placing the at least one section of biomaterial onto a slide; affixing a neuron or a group of neurons to one end portion of the at least one section of biomaterial to create a test construct; incubating the test construct; and determining an amount of neurite growth from the neuron or the group of neurons along the at least one section of biomaterial.
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
Implants comprising living tissue; Implants comprising biological tissue and chemical preparations, composed of a combination of sodium hyaluronate and sodium alginate, for aiding implantation; Surgical implants comprised of biological tissue, namely, animal tissue for medical and veterinary use; Pharmaceutical and veterinary preparations, and delivery systems therefor sold as a unit, for use in regenerative medicine; Pharmaceutical and veterinary preparations, and delivery systems therefor sold as a unit, for wounds; Pharmaceutical and veterinary preparations, and delivery systems therefor sold as a unit, for tissue repair; Pharmaceutical and veterinary preparations, and delivery systems therefor sold as a unit, for surgical repair; Pharmaceutical and veterinary preparations, and delivery systems therefor sold as a unit, acting on the central or peripheral nervous system; Medical and veterinary instruments and devices, namely, tissue grafts and implants comprising living tissue for use in regenerative medicine, wound repair, tissue repair and regeneration, surgical repair, breast reconstruction, eye surgery, corneal surgery, and nerve repair and regeneration; Tissue products for use in regenerative medicine, wound repair, surgical repair, breast reconstruction, eye surgery, corneal surgery, and nerve repair and regeneration; Chemical preparations composed of a combination of sodium hyaluronate and sodium alginate for aiding implantation sold as an integral component of an implant comprising biological tissue Surgical implants comprised of synthetic materials; medical devices, namely, tissue grafts and implants comprising natural, non-living materials, for use in regenerative medicine, wound repair, tissue repair and regeneration, surgical repair, breast reconstruction, eye surgery, corneal surgery, and nerve repair and regeneration; Implants comprising synthetic material; Chemical preparations composed of a combination of sodium hyaluronate and sodium alginate for aiding implantation sold as an integral component of an implant comprising natural, non-living material; Chemical preparations composed of a combination of sodium hyaluronate and sodium alginate for aiding implantation sold as an integral component of an implant comprising synthetic material
48.
FASCICULATED NERVE GRAFTS, METHODS OF MAKING THE SAME, AND METHODS OF TREATMENT USING THE SAME
The present disclosure provides fasciculated nerve grafts of customizable lengths and diameters, and methods of preparing the same. The grafts are made by digesting native extracellular matrix (ECM) around the nerve fascicles of a nerve tissue, and the epineurial sheath. One or more of the individual fascicles may then be entubulated in an entubulation material, embedded in or coated with a coating material, or both, to form a fasciculated nerve graft. The fasciculated nerve grafts are customizable and designed to bridge nerve gaps; the modularity of the fasciculated nerve graft allows for restoring continuity to nerve defects of virtually any length and allows for matching the diameter of the patient's recipient nerve.
The present disclosure pertains to membranous tissue grafts comprising one or more pre-made attachment points. The one or more pre-made attachment points may include pre-made markings and/or pre-made suture holes. The membranous tissue grafts can be in the form of a tube. The membranous tissue grafts can also be rectangular in shape and can be used in a nerve repair by wrapping the severed or damaged nerve. In some embodiments, the membranous tissue grafts are suitable for repairing severed nerves that have a short gap or no gap with a gap of less than 5 mm between the severed stumps. Accordingly, methods are provided for repairing a damaged or severed nerve by implanting the membranous tissue grafts on to the damaged or severed nerve.
A61F 2/00 - Filters implantable into blood vesselsProstheses, i.e. artificial substitutes or replacements for parts of the bodyAppliances for connecting them with the bodyDevices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
An electrical stimulation device may include a handle having a proximal end, a distal end, one or more actuators, and a display. The electrical stimulation device may also include a probe attached to and extending from the distal end of the handle, the probe including a stimulation portion and a return portion, wherein a spacing between the stimulation portion and the return portion is adjustable.
Techniques and systems are disclosed for a bioassay that is an in vitro mimic of peripheral nerve generation using the sensory neurons that innervate the peripheral nervous system. In some embodiments, the techniques may assist in detecting the bioactivity or potency of nerve grafts (e.g., processed, acellular human allografts) for fostering or supporting peripheral nerve regeneration. In various embodiments, techniques comprise affixing a harvested sensory neuron (e.g., a DRG) to a nerve graft segment to form a test construct; culturing the test construct in a medium; analyzing the test construct to indicate the amount of outgrowing peripheral nerve structure; and determining the potency of the nerve graft from a metric derived from the analysis. In some embodiments, techniques and materials may be used to test the effect of a varied test condition on peripheral nerve growth.
An electrical stimulation device may include a handle having a proximal end, a distal end, one or more actuators, and a display. The electrical stimulation device may also include a probe attached to and extending from the distal end of the handle, the probe including a stimulation portion and a return portion, wherein a spacing between the stimulation portion and the return portion is adjustable.
The present disclosure provides engineered nerve grafts, methods of making engineered nerve grafts, and methods of using an engineered nerve graft to repair a nerve. Engineered nerve grafts of the present disclosure may include a body extending from a first end to a second end, the body being formed of a biocompatible hydrogel, and a plurality of microchannels extending continuously through the body from the first end to the second end, wherein each of the plurality of microchannels may have an effective diameter of about 1 micrometer to about 200 micrometers.
The present disclosure provides engineered nerve grafts, methods of making engineered nerve grafts, and methods of using an engineered nerve graft to repair a nerve. Engineered nerve grafts of the present disclosure may include a body extending from a first end to a second end, the body being formed of a biocompatible hydrogel, and a plurality of microchannels extending continuously through the body from the first end to the second end, wherein each of the plurality of microchannels may have an effective diameter of about 1 micrometer to about 200 micrometers.
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
Implants comprising living tissue; Implants comprising biological tissue and chemical preparations for aiding implantation; Surgical implants comprised of biological tissue, namely, animal tissue for medical and veterinary use; Pharmaceutical and veterinary preparations, and delivery systems therefor sold as a unit, for use in regenerative medicine; Pharmaceutical and veterinary preparations, and delivery systems therefor sold as a unit, for wounds; Pharmaceutical and veterinary preparations, and delivery systems therefor sold as a unit, for tissue repair; Pharmaceutical and veterinary preparations, and delivery systems therefor sold as a unit, for surgical repair; Pharmaceutical and veterinary preparations, and delivery systems therefor sold as a unit, acting on the central or peripheral nervous system; Medical and veterinary instruments and devices, namely, tissue grafts and implants comprising living tissue for use in regenerative medicine, wound repair, tissue repair and regeneration, surgical repair, breast reconstruction, eye surgery, corneal surgery, and nerve repair and regeneration; Tissue products, namely, implants comprising living tissue, for use in regenerative medicine, wound repair, surgical repair, breast reconstruction, eye surgery, corneal surgery, and nerve repair and regeneration Surgical implants comprised of synthetic materials; medical devices, namely, tissue grafts and implants comprising natural, non-living materials, for use in regenerative medicine, wound repair, tissue repair and regeneration, surgical repair, breast reconstruction, eye surgery, corneal surgery, and nerve repair and regeneration; Implants comprising synthetic material
58.
DRUG DELIVERY SYSTEM AND METHODS OF USING THE SAME
A method of preparing an implantable biomaterial film includes inputting a combination of a polymer and a neuro-regenerative agent or an immunosuppressive agent into an extruder. The method includes melting the polymer within the extruder. The method also includes extruding the combined polymer and the neuro-regenerative agent or the immunosuppressive agent to form the implantable biomaterial film.
A method of preparing an implantable biomaterial film includes inputting a combination of a polymer and a neuro-regenerative agent or an immunosuppressive agent into an extruder. The method includes melting the polymer within the extruder. The method also includes extruding the combined polymer and the neuro-regenerative agent or the immunosuppressive agent to form the implantable biomaterial film.
A61K 31/436 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
A61K 47/32 - Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers
A61P 25/02 - Drugs for disorders of the nervous system for peripheral neuropathies
61.
Tissue-processing container for automated processing of tissue, methods of use thereof, and systems comprising the same
Tissue-processing containers are disclosed for facilitating multistep processing of tissue. Also disclosed are systems incorporating the tissue-processing containers that include shakers, incubators, controllers, and pumps. Multistep methods are disclosed for processing tissues using the tissue-processing containers. The tissue-processing containers are specially designed to achieve efficiencies in automated tissue processing, exposure of tissues to processing media, and multistep tissue processing protocols. The described tissue-processing containers comprise a cup-like cavity comprising a middle hole covered by a mesh screen, troughs for separate processing steps, and are stackable in a substantially airtight and substantially watertight manner. Tissues for processing using the described tissue-processing containers include nerve tissue. Also described herein is a transport housing for the transport of stacks of tissue-processing containers, and which may directly incubate those containers, or which may be placed inside a separate incubator for incubating the containers.
Tissue-processing containers are disclosed for facilitating multistep processing of tissue. Also disclosed are systems incorporating the tissue-processing containers that include shakers, incubators, controllers, and pumps. Multistep methods are disclosed for processing tissues using the tissue-processing containers. The tissue-processing containers are specially designed to achieve efficiencies in automated tissue processing, exposure of tissues to processing media, and multistep tissue processing protocols. The described tissue-processing containers comprise a cup-like cavity comprising a middle hole covered by a mesh screen, troughs for separate processing steps, and are stackable in a substantially airtight and substantially watertight manner. Tissues for processing using the described tissue-processing containers include nerve tissue. Also described herein is a transport housing for the transport of stacks of tissue-processing containers, and which may directly incubate those containers, or which may be placed inside a separate incubator for incubating the containers.
A system and method are provided for wet storage of tissue. In an embodiment, a solution for the wet preservation of tissue may include between about 0.1% to about 50% by volume dimethyl sulfoxide (DMSO) and one or more soluble monovalent or divalent metal cationic salts. A wet-preserved tissue and method for preparing the wet-preserved tissue for ultimate use, is also provided.
Techniques are described for determining the quality of a nerve graft by assessing quantitative structural characteristics of the nerve graft. Aspects of the techniques include obtaining an image identifying laminin-containing tissue in the nerve graft; creating a transformed image using a transformation function of an image processing application on the image; using an analysis function of the image processing application, analyzing the transformed image to identify one or more structures in accordance with one or more recognition criteria; and determining one or more structural characteristics of the nerve graft derived from a measurement of the one or more structures.
Tissue grafts with reduced regenerative potential, methods of preparing such grafts, and related kits and methods of treatment are described. The method may include treating tissue with a digestion solution comprising trypsin, alpha-chymotrypsin (ACT) and optionally ethylenediaminetetraacetic acid (EDTA) to substantially remove one or more susceptible proteins from the tissue. The method may also include washing the treated tissue with a buffer solution and/or with a serine-containing serum. Nerve grafts prepared according to the disclosed methods may inhibit, or lessen (e.g., provide for reduced) neuroma formation and/or axonal outgrowth after implantation.
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
Implants comprising living tissue; Implants comprising biological tissue and chemical preparations for aiding implantation; Surgical implants comprised of biological tissue, namely, animal tissue for medical and veterinary use; Pharmaceutical and veterinary preparations, and delivery systems therefor sold as a unit, for use in regenerative medicine; Pharmaceutical and veterinary preparations, and delivery systems therefor sold as a unit, for wounds; Pharmaceutical and veterinary preparations, and delivery systems therefor sold as a unit, for tissue repair; Pharmaceutical and veterinary preparations, and delivery systems therefor sold as a unit, for surgical repair; Pharmaceutical and veterinary preparations, and delivery systems therefor sold as a unit, acting on the central or peripheral nervous system; Tissue grafts and implants comprising living tissue for use in regenerative medicine, wound repair, tissue repair and regeneration, surgical repair, breast reconstruction, eye surgery, corneal surgery, and nerve repair and regeneration; Tissue products for use in regenerative medicine, wound repair, surgical repair, breast reconstruction, eye surgery, corneal surgery, and nerve repair and regeneration. Surgical implants comprised of synthetic materials; medical devices, namely, tissue grafts and implants comprising natural, non-living materials, for use in regenerative medicine, wound repair, tissue repair and regeneration, surgical repair, breast reconstruction, eye surgery, corneal surgery, and nerve repair and regeneration; Implants comprising synthetic material.
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
Implants comprising living tissue; Implants comprising biological tissue and chemical preparations for aiding implantation; Surgical implants comprised of biological tissue, namely, animal tissue for medical and veterinary use; Pharmaceutical and veterinary preparations, and delivery systems therefor sold as a unit, for use in regenerative medicine; Pharmaceutical and veterinary preparations, and delivery systems therefor sold as a unit, for wounds; Pharmaceutical and veterinary preparations, and delivery systems therefor sold as a unit, for tissue repair; Pharmaceutical and veterinary preparations, and delivery systems therefor sold as a unit, for surgical repair; Pharmaceutical and veterinary preparations, and delivery systems therefor sold as a unit, acting on the central or peripheral nervous system; Tissue grafts and implants comprising living tissue for use in regenerative medicine, wound repair, tissue repair and regeneration, surgical repair, breast reconstruction, eye surgery, corneal surgery, and nerve repair and regeneration; Tissue products for use in regenerative medicine, wound repair, surgical repair, breast reconstruction, eye surgery, corneal surgery, and nerve repair and regeneration. Surgical implants comprised of synthetic materials; medical devices, namely, tissue grafts and implants comprising natural, non-living materials, for use in regenerative medicine, wound repair, tissue repair and regeneration, surgical repair, breast reconstruction, eye surgery, corneal surgery, and nerve repair and regeneration; Implants comprising synthetic material.
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
(1) Implants comprising living tissue; Implants comprising biological tissue and chemical preparations for aiding implantation; Surgical implants comprised of biological tissue, namely, animal tissue for medical and veterinary use; Pharmaceutical and veterinary preparations, and delivery systems therefor sold as a unit, for use in regenerative medicine; Pharmaceutical and veterinary preparations, and delivery systems therefor sold as a unit, for wounds; Pharmaceutical and veterinary preparations, and delivery systems therefor sold as a unit, for tissue repair; Pharmaceutical and veterinary preparations, and delivery systems therefor sold as a unit, for surgical repair; Pharmaceutical and veterinary preparations, and delivery systems therefor sold as a unit, acting on the central or peripheral nervous system; Medical and veterinary instruments and devices, namely, tissue grafts and implants comprising living tissue for use in regenerative medicine, wound repair, tissue repair and regeneration, surgical repair, breast reconstruction, eye surgery, corneal surgery, and nerve repair and regeneration; Tissue products for use in regenerative medicine, wound repair, surgical repair, breast reconstruction, eye surgery, corneal surgery, and nerve repair and regeneration
(2) Surgical implants comprised of synthetic materials; medical devices, namely, tissue grafts and implants comprising natural, non-living materials, for use in regenerative medicine, wound repair, tissue repair and regeneration, surgical repair, breast reconstruction, eye surgery, corneal surgery, and nerve repair and regeneration; Implants comprising synthetic material
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
(1) Implants comprising living tissue; Implants comprising biological tissue and chemical preparations for aiding implantation; Surgical implants comprised of biological tissue, namely, animal tissue for medical and veterinary use; Pharmaceutical and veterinary preparations, and delivery systems therefor sold as a unit, for use in regenerative medicine; Pharmaceutical and veterinary preparations, and delivery systems therefor sold as a unit, for wounds; Pharmaceutical and veterinary preparations, and delivery systems therefor sold as a unit, for tissue repair; Pharmaceutical and veterinary preparations, and delivery systems therefor sold as a unit, for surgical repair; Pharmaceutical and veterinary preparations, and delivery systems therefor sold as a unit, acting on the central or peripheral nervous system; Medical and veterinary instruments and devices, namely, tissue grafts and implants comprising living tissue for use in regenerative medicine, wound repair, tissue repair and regeneration, surgical repair, breast reconstruction, eye surgery, corneal surgery, and nerve repair and regeneration; Tissue products for use in regenerative medicine, wound repair, surgical repair, breast reconstruction, eye surgery, corneal surgery, and nerve repair and regeneration
(2) Surgical implants comprised of synthetic materials; medical devices, namely, tissue grafts and implants comprising natural, non-living materials, for use in regenerative medicine, wound repair, tissue repair and regeneration, surgical repair, breast reconstruction, eye surgery, corneal surgery, and nerve repair and regeneration; Implants comprising synthetic material
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
(1) Implants comprising living tissue; Surgical implants comprised of biological tissue, namely, human or animal tissue for medical and veterinary use; Pharmaceutical and veterinary preparations, and delivery systems therefor sold as a unit, for use in regenerative medicine; Pharmaceutical and veterinary preparations, and delivery systems therefor sold as a unit, for wounds; Pharmaceutical and veterinary preparations, and delivery systems therefor sold as a unit, for tissues repair; Pharmaceutical and veterinary preparations, and delivery systems therefor sold as a unit, for surgical repair; Pharmaceutical and veterinary preparations, and delivery systems therefor sold as a unit, acting on the central or peripheral nervous system; Medical and veterinary instruments and devices, namely, tissue grafts and implants comprising living tissue for use in regenerative medicine, wound repair, tissue repair and regeneration, surgical repair, breast reconstruction, eye surgery, corneal surgery, and nerve repair and regeneration; Tissue products for use in regenerative medicine, wound repair, surgical repair, breast reconstruction, eye surgery, corneal surgery, and nerve repair and regeneration
(2) Surgical implants comprised of synthetic materials; medical devices, namely, tissue grafts and implants comprising natural, non-living materials, for use in regenerative medicine, wound repair, tissue repair and regeneration, surgical repair, breast reconstruction, eye surgery, corneal surgery, and nerve repair and regeneration; Implants comprising synthetic material
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
(1) Implants comprising living tissue; Surgical implants comprised of biological tissue, namely, human or animal tissue for medical and veterinary use; Pharmaceutical and veterinary preparations, and delivery systems therefor sold as a unit, for use in regenerative medicine; Pharmaceutical and veterinary preparations, and delivery systems therefor sold as a unit, for wounds; Pharmaceutical and veterinary preparations, and delivery systems therefor sold as a unit, for tissues repair; Pharmaceutical and veterinary preparations, and delivery systems therefor sold as a unit, for surgical repair; Pharmaceutical and veterinary preparations, and delivery systems therefor sold as a unit, acting on the central or peripheral nervous system; Medical and veterinary instruments and devices, namely, tissue grafts and implants comprising living tissue for use in regenerative medicine, wound repair, tissue repair and regeneration, surgical repair, breast reconstruction, eye surgery, corneal surgery, and nerve repair and regeneration; Tissue products for use in regenerative medicine, wound repair, surgical repair, breast reconstruction, eye surgery, corneal surgery, and nerve repair and regeneration
(2) Surgical implants comprised of synthetic materials; medical devices, namely, tissue grafts and implants comprising natural, non-living materials, for use in regenerative medicine, wound repair, tissue repair and regeneration, surgical repair, breast reconstruction, eye surgery, corneal surgery, and nerve repair and regeneration; Implants comprising synthetic material
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
Implants comprising living tissue; Surgical implants comprised of biological tissue, namely, human or animal tissue for medical use; Pharmaceutical preparations, and delivery systems therefor sold as a unit, for use in regenerative medicine; Pharmaceutical preparations, and delivery systems therefor sold as a unit, for wounds; Pharmaceutical preparations, and delivery systems therefor sold as a unit, for tissues repair; Pharmaceutical preparations, and delivery systems therefor sold as a unit, for surgical repair; Pharmaceutical preparations, and delivery systems therefor sold as a unit, acting on the central or peripheral nervous system; Tissue grafts and implants comprising living tissue for use in regenerative medicine, wound repair, tissue repair and regeneration, surgical repair, breast reconstruction, eye surgery, corneal surgery, and nerve repair and regeneration; Tissue products for use in regenerative medicine, wound repair, surgical repair, breast reconstruction, eye surgery, corneal surgery, and nerve repair and regeneration. Surgical implants comprised of synthetic materials; medical devices, namely, tissue grafts and implants comprising natural, non-living materials, for use in regenerative medicine, wound repair, tissue repair and regeneration, surgical repair, breast reconstruction, eye surgery, corneal surgery, and nerve repair and regeneration; Implants comprising synthetic material.
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
Implants comprising living tissue; Surgical implants comprised of biological tissue, namely, human or animal tissue for medical use; Pharmaceutical preparations, and delivery systems therefor sold as a unit, for use in regenerative medicine; Pharmaceutical preparations, and delivery systems therefor sold as a unit, for wounds; Pharmaceutical preparations, and delivery systems therefor sold as a unit, for tissues repair; Pharmaceutical preparations, and delivery systems therefor sold as a unit, for surgical repair; Pharmaceutical preparations, and delivery systems therefor sold as a unit, acting on the central or peripheral nervous system; Tissue grafts and implants comprising living tissue for use in regenerative medicine, wound repair, tissue repair and regeneration, surgical repair, breast reconstruction, eye surgery, corneal surgery, and nerve repair and regeneration; Tissue products for use in regenerative medicine, wound repair, surgical repair, breast reconstruction, eye surgery, corneal surgery, and nerve repair and regeneration. Surgical implants comprised of synthetic materials; medical devices, namely, tissue grafts and implants comprising natural, non-living materials, for use in regenerative medicine, wound repair, tissue repair and regeneration, surgical repair, breast reconstruction, eye surgery, corneal surgery, and nerve repair and regeneration; Implants comprising synthetic material.
A capture-tool for manipulation of tissue utilizes vacuum to hold the tissue in place. An extension attached to a vacuum source at one end and a vacuum arm at another end creates a vacuum force through the extension and vacuum arm. The vacuum arm has a support surface with ports therein at which low pressure areas are formed by the vacuum force. The low pressure areas draw tissue against the supporting surface to hold it in place, as long as the vacuum force is active.
A tissue connector may include a body formed of one or more layers of material, and at least one barbed suture attached to the body, wherein the barbed suture is formed of a biodegradable material. A method of forming a tissue connector may include forming a body from one or more layers of a material, and attaching at least one barbed suture to the body, wherein the barbed suture is formed of a biodegradable material. A method of repairing tissue using a tissue connector may include orienting the tissue connector around coapted or damaged tissue, so that the coapted or damaged tissue contacts the inner surface of the tissue connector, twisting ends of the at least one barbed suture so that the at least one barbed suture engages the coapted or damaged tissue, and allowing the tissue connector to remain in place, so that the barbed suture degrades over time.
A multi-layer amnion product may include a plurality of layers oriented on top of one another, wherein the plurality of layers includes at least one chorion membrane layer and at least two amnion layers. The plurality of layers may include at least four layers and less than ten layers. At least two of the at least two amnion layers may form outermost layers of the plurality of layers. Each amnion layer may include an epithelial layer, a basement membrane, and a fibroblast layer, and each chorion layer may include a reticular layer and a basement membrane.
A multi-layer amnion product may include a plurality of layers oriented on top of one another, wherein the plurality of layers includes at least one chorion membrane layer and at least two amnion layers. The plurality of layers may include at least four layers and less than ten layers. At least two of the at least two amnion layers may form outermost layers of the plurality of layers. Each amnion layer may include an epithelial layer, a basement membrane, and a fibroblast layer, and each chorion layer may include a reticular layer and a basement membrane.
A tissue connector may include a body formed of one or more layers of material, and at least one barbed suture attached to the body. A related method of forming a tissue connector may include forming a body from one or more layers of a material, and attaching at least one barbed suture to the body. In addition, a related method of repairing tissue using a tissue connector may include orienting the tissue connector around coapted or damaged tissue, so that the coapted or damaged tissue contacts the inner surface of the tissue connector, and twisting ends of the at least one barbed suture so that the at least one barbed suture engages the coapted or damaged tissue.
A61B 17/06 - NeedlesHolders or packages for needles or suture materials
A61B 17/11 - Surgical instruments, devices or methods for closing wounds or holding wounds closedAccessories for use therewith for performing anastomosisButtons for anastomosis
80.
SUTURELESS CONNECTORS AND METHODS OF PREPARING AND USING SAME
A tissue connector may include a body formed of one or more layers of material, and at least one barbed suture attached to the body. A related method of forming a tissue connector may include forming a body from one or more layers of a material, and attaching at least one barbed suture to the body. In addition, a related method of repairing tissue using a tissue connector may include orienting the tissue connector around coapted or damaged tissue, so that the coapted or damaged tissue contacts the inner surface of the tissue connector, and twisting ends of the at least one barbed suture so that the at least one barbed suture engages the coapted or damaged tissue.
A61B 17/06 - NeedlesHolders or packages for needles or suture materials
A61B 17/11 - Surgical instruments, devices or methods for closing wounds or holding wounds closedAccessories for use therewith for performing anastomosisButtons for anastomosis
81.
SUTURELESS CONNECTORS AND METHODS OF PREPARING AND USING SAME
A tissue connector may include a body formed of one or more layers of material, and at least one barbed suture attached to the body. A related method of forming a tissue connector may include forming a body from one or more layers of a material, and attaching at least one barbed suture to the body. In addition, a related method of repairing tissue using a tissue connector may include orienting the tissue connector around coapted or damaged tissue, so that the coapted or damaged tissue contacts the inner surface of the tissue connector, and twisting ends of the at least one barbed suture so that the at least one barbed suture engages the coapted or damaged tissue.
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
Implants comprising living tissue; Surgical implants comprised of biological tissue, namely, human or animal tissue for medical and veterinary use; Pharmaceutical and veterinary preparations, and delivery systems therefor sold as a unit, for use in regenerative medicine; Pharmaceutical and veterinary preparations, and delivery systems therefor sold as a unit, for wounds; Pharmaceutical and veterinary preparations, and delivery systems therefor sold as a unit, for tissues repair; Pharmaceutical and veterinary preparations, and delivery systems therefor sold as a unit, for surgical repair; Pharmaceutical and veterinary preparations, and delivery systems therefor sold as a unit, acting on the central or peripheral nervous system; Medical and veterinary devices, namely, tissue grafts and implants comprising living tissue for use in regenerative medicine, wound repair, tissue repair and regeneration, surgical repair, breast reconstruction and nerve repair and regeneration; Tissue products for use in regenerative medicine, wound repair, surgical repair, breast reconstruction and nerve repair and regeneration Medical devices, namely, tissue grafts and implants comprising natural, non-living materials, for use in regenerative medicine, wound repair, tissue repair and regeneration, surgical repair, breast reconstruction and nerve repair and regeneration
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
Implants comprising living tissue; Surgical implants comprised of biological tissue, namely, human or animal tissue for medical and veterinary use; Pharmaceutical and veterinary preparations, and delivery systems therefor sold as a unit, for use in regenerative medicine; Pharmaceutical and veterinary preparations, and delivery systems therefor sold as a unit, for wounds; Pharmaceutical and veterinary preparations, and delivery systems therefor sold as a unit, for tissues repair; Pharmaceutical and veterinary preparations, and delivery systems therefor sold as a unit, for surgical repair; Pharmaceutical and veterinary preparations, and delivery systems therefor sold as a unit, acting on the central or peripheral nervous system; Medical and veterinary devices, namely, tissue grafts and implants comprising living tissue for use in regenerative medicine, wound repair, tissue repair and regeneration, surgical repair, breast reconstruction and nerve repair and regeneration; Tissue products for use in regenerative medicine, wound repair, surgical repair, breast reconstruction and nerve repair and regeneration Medical devices, namely, tissue grafts and implants comprising natural, non-living materials, for use in regenerative medicine, wound repair, tissue repair and regeneration, surgical repair, breast reconstruction and nerve repair and regeneration
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
Implants comprising living tissue; Implants comprising biological tissue and chemical preparations for aiding implantation; Surgical implants comprised of biological tissue, namely, animal tissue for medical and veterinary use; Pharmaceutical and veterinary preparations, and delivery systems therefor sold as a unit, for use in regenerative medicine; Pharmaceutical and veterinary preparations, and delivery systems therefor sold as a unit, for wounds; Pharmaceutical and veterinary preparations, and delivery systems therefor sold as a unit, for tissue repair; Pharmaceutical and veterinary preparations, and delivery systems therefor sold as a unit, for surgical repair; Pharmaceutical and veterinary preparations, and delivery systems therefor sold as a unit, acting on the central or peripheral nervous system; Medical and veterinary instruments and devices, namely, tissue grafts and implants comprising living tissue for use in regenerative medicine, wound repair, tissue repair and regeneration, surgical repair, breast reconstruction, eye surgery, corneal surgery, and nerve repair and regeneration; Tissue products for use in regenerative medicine, wound repair, surgical repair, breast reconstruction, eye surgery, corneal surgery, and nerve repair and regeneration Surgical implants comprised of synthetic materials; medical devices, namely, tissue grafts and implants comprising natural, non-living materials, for use in regenerative medicine, wound repair, tissue repair and regeneration, surgical repair, breast reconstruction, eye surgery, corneal surgery, and nerve repair and regeneration; Implants comprising synthetic material
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
Implants comprising living tissue; Implants comprising biological tissue and chemical preparations for aiding implantation; Surgical implants comprised of biological tissue, namely, animal tissue for medical and veterinary use; Pharmaceutical and veterinary preparations, and delivery systems therefor sold as a unit, for use in regenerative medicine; Pharmaceutical and veterinary preparations, and delivery systems therefor sold as a unit, for wounds; Pharmaceutical and veterinary preparations, and delivery systems therefor sold as a unit, for tissue repair; Pharmaceutical and veterinary preparations, and delivery systems therefor sold as a unit, for surgical repair; Pharmaceutical and veterinary preparations, and delivery systems therefor sold as a unit, acting on the central or peripheral nervous system; Medical and veterinary instruments and devices, namely, tissue grafts and implants comprising living tissue for use in regenerative medicine, wound repair, tissue repair and regeneration, surgical repair, breast reconstruction, eye surgery, corneal surgery, and nerve repair and regeneration; Tissue products for use in regenerative medicine, wound repair, surgical repair, breast reconstruction, eye surgery, corneal surgery, and nerve repair and regeneration Surgical implants comprised of synthetic materials; medical devices, namely, tissue grafts and implants comprising natural, non-living materials, for use in regenerative medicine, wound repair, tissue repair and regeneration, surgical repair, breast reconstruction, eye surgery, corneal surgery, and nerve repair and regeneration; Implants comprising synthetic material
86.
SYSTEMS AND METHODS FOR DETECTION OF LAMININ BETA-1 SUBUNIT WITHIN TISSUE
A method for performing an enzyme-linked immunosorbent assay (ELISA), the method comprising immobilizing a capture antibody to a substrate, wherein the capture antibody is configured to bind to a laminin beta-1 chain; adding a micronized tissue sample to the substrate containing the capture antibody; adding a detection antibody to the substrate containing the capture antibody and the micronized tissue sample, wherein the detection antibody is configured to bind to a laminin gamma- 1 chain; detecting whether a complex of the capture antibody, a target antigen in the micronized tissue sample, and the detection antibody has been formed, wherein presence of the complex indicates presence of the target antigen with intact tertiary structure in the micronized tissue sample, and absence of the complex indicates absence of the target antigen with intact tertiary structure in the micronized tissue sample.
The present disclosure provides tissue wrap devices with embedded three dimensional attachment features, methods of manufacturing three-dimensional attachment features for tissue wrap devices, and methods of using a nerve wrap device to protect a damaged nerve. Tissue wrap devices of the present disclosure may include a sheet of biocompatible material, the sheet having a first side, a second side, a middle portion, a first outer portion, and a second outer portion, the first side of the first outer portion being configured to overlap and interface with the second side of the second outer portion when the sheet is transitioned to a rolled configuration; wherein the first side of the first outer portion comprises a plurality of three dimensional attachment features; and wherein the plurality of three dimensional attachment features are configured to engage with the second side of the second outer portion to maintain the sheet in the rolled configuration.
A61B 17/11 - Surgical instruments, devices or methods for closing wounds or holding wounds closedAccessories for use therewith for performing anastomosisButtons for anastomosis
A method for performing an enzyme-linked immunosorbent assay (ELISA), the method comprising immobilizing a capture antibody to a substrate, wherein the capture antibody is configured to bind to a laminin beta-1 chain; adding a micronized tissue sample to the substrate containing the capture antibody; adding a detection antibody to the substrate containing the capture antibody and the micronized tissue sample, wherein the detection antibody is configured to bind to a laminin gamma- 1 chain; detecting whether a complex of the capture antibody, a target antigen in the micronized tissue sample, and the detection antibody has been formed, wherein presence of the complex indicates presence of the target antigen with intact tertiary structure in the micronized tissue sample, and absence of the complex indicates absence of the target antigen with intact tertiary structure in the micronized tissue sample.
An electrode apparatus may include a handle, a cannula extending from a distal end of the handle and having at least one lumen, a ground wire extending through the cannula, and an electrode wire extending through the handle and the cannula, the electrode wire being extendable and retractable relative to a distal end of the cannula. The apparatus may also include a hook, provided in the cannula, and being extendable and retractable relative to the cannula.
An electrode apparatus may include a handle, a cannula extending from a distal end of the handle and having at least one lumen, a ground wire extending through the cannula, and an electrode wire extending through the handle and the cannula, the electrode wire being extendable and retractable relative to a distal end of the cannula. The apparatus may also include a hook, provided in the cannula, and being extendable and retractable relative to the cannula.
The present disclosure provides tissue wrap devices with embedded three dimensional attachment features, methods of manufacturing three-dimensional attachment features for tissue wrap devices, and methods of using a nerve wrap device to protect a damaged nerve. Tissue wrap devices of the present disclosure may include a sheet of biocompatible material, the sheet having a first side, a second side, a middle portion, a first outer portion, and a second outer portion, the first side of the first outer portion being configured to overlap and interface with the second side of the second outer portion when the sheet is transitioned to a rolled configuration; wherein the first side of the first outer portion comprises a plurality of three dimensional attachment features; and wherein the plurality of three dimensional attachment features are configured to engage with the second side of the second outer portion to maintain the sheet in the rolled configuration.
A61F 2/00 - Filters implantable into blood vesselsProstheses, i.e. artificial substitutes or replacements for parts of the bodyAppliances for connecting them with the bodyDevices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
A61M 37/00 - Other apparatus for introducing media into the bodyPercutany, i.e. introducing medicines into the body by diffusion through the skin
A61B 17/00 - Surgical instruments, devices or methods
A method for performing an enzyme-linked immunosorbent assay (ELISA), the method comprising immobilizing a capture antibody to a substrate, wherein the capture antibody is configured to bind to a laminin beta-1 chain; adding a micronized tissue sample to the substrate containing the capture antibody; adding a detection antibody to the substrate containing the capture antibody and the micronized tissue sample, wherein the detection antibody is configured to bind to a laminin gamma-1 chain; detecting whether a complex of the capture antibody, a target antigen in the micronized tissue sample, and the detection antibody has been formed, wherein presence of the complex indicates presence of the target antigen with intact tertiary structure in the micronized tissue sample, and absence of the complex indicates absence of the target antigen with intact tertiary structure in the micronized tissue sample.
A method of preparing a nerve graft includes submerging a nerve graft in a solution including FK506 and a solvent to promote incorporation of FK506 into the nerve graft. A tissue graft includes nerve tissue and FK506 incorporated within the nerve tissue. In the tissue graft, the FK506 is free of hydrogel and not encapsulated.
A method of preparing an implantable biomaterial includes combining a polymer comprising polydioxanone with a neuro-regenerative agent or an immunosuppressive agent comprising at least one immunophilin ligand, and melting the polymer. The method further includes extruding the combined polymer and the neuro-regenerative agent or immunosuppressive agent to form the implantable biomaterial.
A method for preserving a tissue graft includes submerging the tissue graft in a solution containing one or more antimicrobial and/or stabilizing agents and storing the tissue graft in the solution for a period of time of at least 24 hours while the solution is in an unfrozen state. A tissue preservation system includes a solution containing one or more antimicrobial and/or stabilizing agents and a tissue graft in the solution.
A method of preparing an implantable biomaterial includes combining a polymer with a neuro-regenerative agent or immunosuppressive agent selected from a group comprising at least one of: rapamycin, cyclosporine A, or analogs thereof, melting the polymer, and extruding the polymer and the neuro-regenerative agent or immunosuppressive agent to form the implantable biomaterial.
A method of preparing an implantable biomaterial includes combining a polymer comprising polydioxanone with a neuro-regenerative agent or an immunosuppressive agent comprising at least one immunophilin ligand, and melting the polymer. The method further includes extruding the combined polymer and the neuro-regenerative agent or immunosuppressive agent to form the implantable biomaterial.
A method of preparing a nerve graft includes submerging a nerve graft in a solution including FK506 and a solvent to promote incorporation of FK506 into the nerve graft. A tissue graft includes nerve tissue and FK506 incorporated within the nerve tissue. In the tissue graft, the FK506 is free of hydrogel and not encapsulated.
An electrode apparatus may include a handle, a cannula extending from a distal end of the handle and having at least one lumen, a ground wire extending through the cannula, and an electrode wire extending through the handle and the cannula, the electrode wire being extendable and retractable relative to a distal end of the cannula. The apparatus may also include a hook, provided in the cannula, and being extendable and retractable relative to the cannula.
A method of preparing an implantable biomaterial includes combining a polymer with a neuro-regenerative agent or immunosuppressive agent selected from a group comprising at least one of: rapamycin, cyclosporine A, or analogs thereof, melting the polymer, and extruding the polymer and the neuro-regenerative agent or immunosuppressive agent to form the implantable biomaterial.
