Abstract

Described here are VHH antibody libraries with heavy chain variable domains framework scaffolds having complementary determining regions (CDRs) found in naturally-occurring human antibodies, and methods of making such antibody libraries. The antibody libraries are free of members that comprise one or more liabilities affecting one or more features of such members.

IPC Classes  ?

• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
• C07K 16/24 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
• C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
• C07K 16/36 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
• C07K 16/40 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against enzymes

Abstract

Antibody libraries comprising a plurality of heavy chain variable domains and/or a plurality of light chain variable domains, which comprise complementary determining regions (CDRs) found in naturally-occurring human antibodies, and methods of making such antibody libraries. The antibody libraries are free of members that comprise one or more liabilities affecting one or more features of such members. Further, the antibody libraries comprise members having heavy chain and/or light chain CDRs not found in the same naturally-occurring human antibody.

IPC Classes  ?

• C40B 40/10 - Libraries containing peptides or polypeptides, or derivatives thereof
• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
• C12N 15/81 - Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
• C40B 40/08 - Libraries containing RNA or DNA which encodes proteins, e.g. gene libraries
• C40B 50/06 - Biochemical methods, e.g. using enzymes or whole viable microorganisms

Abstract

Provided herein is an improved method of antibody affinity maturation that uses true natural CDRs from a population of naturally occurring antibodies targeting a single antigen or antigenic epitope such that the improved method produces functional antibodies having low-picomolar affinity antibodies. Also provided herein is an antibody library where the CDRs within a single antibody member of the library are a combination of CDR sequences of naturally occurring antibodies and one or more CDRs are derived from different naturally occurring antibodies targeting a single antigen or antigenic epitope.

IPC Classes  ?

• C40B 40/10 - Libraries containing peptides or polypeptides, or derivatives thereof
• C07K 16/00 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies
• C40B 50/00 - Methods of creating libraries, e.g. combinatorial synthesis

Abstract

Antibody libraries comprising a plurality of heavy chain variable domains and/or a plurality of light chain variable domains, which comprise complementary determining regions (CDRs) found in naturally-occurring human antibodies, and methods of making such antibody libraries. The antibody libraries are free of members that comprise one or more liabilities affecting one or more features of such members. Further, the antibody libraries comprise members having heavy chain and/or light chain CDRs not found in the same naturally-occurring human antibody.

IPC Classes  ?

• C40B 50/06 - Biochemical methods, e.g. using enzymes or whole viable microorganisms
• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
• C12N 15/81 - Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
• C40B 40/10 - Libraries containing peptides or polypeptides, or derivatives thereof
• C40B 40/08 - Libraries containing RNA or DNA which encodes proteins, e.g. gene libraries

Abstract

Antibody libraries comprising a plurality of heavy chain variable domains and/or a plurality of light chain variable domains, which comprise complementary determining regions (CDRs) found in naturally-occurring human antibodies, and methods of making such antibody libraries. The antibody libraries are free of members that comprise one or more liabilities affecting one or more features of such members. Further, the antibody libraries comprise members having heavy chain and/or light chain CDRs not found in the same naturally-occurring human antibody.

IPC Classes  ?

• C40B 40/10 - Libraries containing peptides or polypeptides, or derivatives thereof
• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
• C12N 15/81 - Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
• C40B 40/08 - Libraries containing RNA or DNA which encodes proteins, e.g. gene libraries
• C40B 50/06 - Biochemical methods, e.g. using enzymes or whole viable microorganisms

Abstract

Antibody libraries comprising a plurality of heavy chain variable domains and/or a plurality of light chain variable domains, which comprise complementary determining regions (CDRs) found in naturally-occurring human antibodies, and methods of making such antibody libraries. The antibody libraries are free of members that comprise one or more liabilities affecting one or more features of such members. Further, the antibody libraries comprise members having heavy chain and/or light chain CDRs not found in the same naturally-occurring human antibody.

IPC Classes  ?

• C40B 50/06 - Biochemical methods, e.g. using enzymes or whole viable microorganisms
• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
• C12N 15/81 - Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
• C40B 40/10 - Libraries containing peptides or polypeptides, or derivatives thereof
• C40B 40/08 - Libraries containing RNA or DNA which encodes proteins, e.g. gene libraries

Abstract

Antibody libraries comprising a plurality of heavy chain variable domains and/or a plurality of light chain variable domains, which comprise complementary determining regions (CDRs) found in naturally-occurring human antibodies, and methods of making such antibody libraries. The antibody libraries are free of members that comprise one or more liabilities affecting one or more features of such members. Further, the antibody libraries comprise members having heavy chain and/or light chain CDRs not found in the same naturally-occurring human antibody.

IPC Classes  ?

• C40B 40/10 - Libraries containing peptides or polypeptides, or derivatives thereof
• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
• C12N 15/81 - Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
• C40B 40/08 - Libraries containing RNA or DNA which encodes proteins, e.g. gene libraries
• C40B 50/06 - Biochemical methods, e.g. using enzymes or whole viable microorganisms

Abstract

Described here are VHH antibody libraries with heavy chain variable domains framework scaffolds having complementary determining regions (CDRs) found in naturally-occurring human antibodies, and methods of making such antibody libraries. The antibody libraries are free of members that comprise one or more liabilities affecting one or more features of such members.

IPC Classes  ?

• C40B 50/06 - Biochemical methods, e.g. using enzymes or whole viable microorganisms
• C07K 16/00 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies
• C40B 40/10 - Libraries containing peptides or polypeptides, or derivatives thereof

Abstract

Described here are VHH antibody libraries with heavy chain variable domains framework scaffolds having complementary determining regions (CDRs) found in naturally-occurring human antibodies, and methods of making such antibody libraries. The antibody libraries are free of members that comprise one or more liabilities affecting one or more features of such members.

IPC Classes  ?

• A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum
• C12N 5/10 - Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells
• C40B 40/08 - Libraries containing RNA or DNA which encodes proteins, e.g. gene libraries

Abstract

Provided herein is an improved method of antibody affinity maturation that uses true natural CDRs from a population of naturally occurring antibodies targeting a single antigen or antigenic epitope such that the improved method produces functional antibodies having low-picomolar affinity antibodies. Also provided herein is an antibody library where the CDRs within a single antibody member of the library are a combination of CDR sequences of naturally occurring antibodies and one or more CDRs are derived from different naturally occurring antibodies targeting a single antigen or antigenic epitope.

IPC Classes  ?

• C07K 16/00 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies

Goods & Services

Downloadable software for the management, storage, sharing, processing, visualization and analysis of DNA and amino acid sequences, biological data and associated laboratory data for the purposes of biomolecular research, high-throughput sampling through next-generation sequencing platforms, lead characterization, drug discovery and the design and engineering of biomolecular products Providing temporary use of online non-downloadable software for the management, storage, sharing, processing, visualization and analysis of DNA and amino acid sequences, biological data and associated laboratory data for the purposes of biomolecular research, high-throughput sampling through next-generation sequencing platforms, lead characterization, drug discovery and the design and engineering of biomolecular products; Software as a service (SAAS) services featuring software for the management, storage, sharing, processing, visualization and analysis of DNA and amino acid sequences, biological data and associated laboratory data for the purposes of biomolecular research, high-throughput sampling through next-generation sequencing platforms, lead characterization, drug discovery and the design and engineering of biomolecular products

Abstract

Antibody libraries comprising a plurality of heavy chain variable domains and/or a plurality of light chain variable domains, which comprise complementary determining regions (CDRs) found in naturally-occurring human antibodies, and methods of making such antibody libraries. The antibody libraries are free of members that comprise one or more liabilities affecting one or more features of such members. Further, the antibody libraries comprise members having heavy chain and/or light chain CDRs not found in the same naturally-occurring human antibody.

IPC Classes  ?

• C40B 50/06 - Biochemical methods, e.g. using enzymes or whole viable microorganisms
• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
• C12N 15/81 - Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
• C40B 40/10 - Libraries containing peptides or polypeptides, or derivatives thereof
• C40B 40/08 - Libraries containing RNA or DNA which encodes proteins, e.g. gene libraries

Abstract

Antibody libraries comprising a plurality of heavy chain variable domains and/or a plurality of light chain variable domains, which comprise complementary determining regions (CDRs) found in naturally-occurring human antibodies, and methods of making such antibody libraries. The antibody libraries are free of members that comprise one or more liabilities affecting one or more features of such members. Further, the antibody libraries comprise members having heavy chain and/or light chain CDRs not found in the same naturally-occurring human antibody.

IPC Classes  ?

• C40B 50/06 - Biochemical methods, e.g. using enzymes or whole viable microorganisms
• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
• C12N 15/81 - Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
• C40B 40/10 - Libraries containing peptides or polypeptides, or derivatives thereof
• C40B 40/08 - Libraries containing RNA or DNA which encodes proteins, e.g. gene libraries

Abstract

Antibody libraries comprising a plurality of heavy chain variable domains and/or a plurality of light chain variable domains, which comprise complementary determining regions (CDRs) found in naturally-occurring human antibodies, and methods of making such antibody libraries. The antibody libraries are free of members that comprise one or more liabilities affecting one or more features of such members. Further, the antibody libraries comprise members having heavy chain and/or light chain CDRs not found in the same naturally-occurring human antibody.

IPC Classes  ?

• C07K 16/18 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans
• C07K 16/46 - Hybrid immunoglobulins
• C12N 15/09 - Recombinant DNA-technology
• C12P 21/08 - Monoclonal antibodies
• C40B 40/08 - Libraries containing RNA or DNA which encodes proteins, e.g. gene libraries
• C40B 40/10 - Libraries containing peptides or polypeptides, or derivatives thereof

Abstract

Antibody libraries comprising a plurality of heavy chain variable domains and/or a plurality of light chain variable domains, which comprise complementary determining regions (CDRs) found in naturally-occurring human antibodies, and methods of making such antibody libraries. The antibody libraries are free of members that comprise one or more liabilities affecting one or more features of such members. Further, the antibody libraries comprise members having heavy chain and/or light chain CDRs not found in the same naturally-occurring human antibody.

IPC Classes  ?

• C40B 40/08 - Libraries containing RNA or DNA which encodes proteins, e.g. gene libraries
• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
• C12N 15/81 - Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
• C40B 40/10 - Libraries containing peptides or polypeptides, or derivatives thereof

Abstract

Methods and devices for predicting, diagnosing, monitoring, or determining Alzheimer's disease in a human are described. In particular, methods and devices for predicting diagnosing, monitoring, or determining AD using measured concentrations of a combination of three or more analytes in a test sample taken from the human are described.

IPC Classes  ?

• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids

Abstract

Methods and devices for diagnosing, monitoring, or determining a renal disorder in a mammal are described. In particular, methods and devices for diagnosing, monitoring, or determining a renal disorder using measured concentrations of a combination of three or more analytes in a test sample taken from the mammal are described.

IPC Classes  ?

• A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum
• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids

Abstract

Devices for diagnosing, monitoring, or determining a renal disorder in a mammal are described. In particular, devices for diagnosing, monitoring, or determining a renal disorder using measured concentrations of a combination of three or more analytes in a test sample taken from the mammal are described.

IPC Classes  ?

• G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals

Abstract

Methods and devices for diagnosing, monitoring, or determining diabetic nephropathy or an associated disorder in a mammal are described. In particular, methods and devices for diagnosing, monitoring, or determining diabetic nephropathy or an associated disorder using measured concentrations of a combination of three or more analytes in a test sample taken from the mammal are described.

IPC Classes  ?

• G01N 33/48 - Biological material, e.g. blood, urineHaemocytometers

Abstract

Methods and devices for diagnosing, monitoring, or determining obstructive uropathy or an associated disorder in a mammal are described. In particular, methods and devices for diagnosing, monitoring, or determining obstructive uropathy or an associated disorder using measured concentrations of a combination of three or more analytes in a test sample taken from the mammal are described.

IPC Classes  ?

• G01N 33/48 - Biological material, e.g. blood, urineHaemocytometers
• G01N 33/53 - ImmunoassayBiospecific binding assayMaterials therefor

Abstract

Methods and devices for diagnosing, monitoring, or determining glomerulonephritis or an associated disorder in a mammal are described. In particular, methods and devices for diagnosing, monitoring, or determining glomerulonephritis or an associated disorder using measured concentrations of a combination of three or more analytes in a test sample taken from the mammal are described.

IPC Classes  ?

• G01N 33/53 - ImmunoassayBiospecific binding assayMaterials therefor

Abstract

Methods and devices for diagnosing, monitoring, or determining kidney damage in a mammal are described. In particular, methods and devices for diagnosing, monitoring, or determining kidney damage using measured concentrations of a combination of three or more analytes in a test sample taken from the mammal are described.

IPC Classes  ?

• G01N 33/566 - ImmunoassayBiospecific binding assayMaterials therefor using specific carrier or receptor proteins as ligand binding reagent
• G01N 33/53 - ImmunoassayBiospecific binding assayMaterials therefor

Abstract

Methods and devices for diagnosing, monitoring, or determining kidney transplant rejection or an associated disorder in a mammal are described. In particular, methods and devices for diagnosing, monitoring, or determining kidney transplant rejection or an associated disorder using measured concentrations of a combination of three or more analytes in a test sample taken from the mammal are described.

IPC Classes  ?

• G01N 33/48 - Biological material, e.g. blood, urineHaemocytometers

Abstract

The present invention refers to a cell culture system especially for investigating the sensitizing, allergenic and/or irritating effect of substances, comprising a first and a second compartment that can communicate with each other via a permeable interlayer, whereby the first compartment has an epidermis model and the second a cell culture based on immune cells.

IPC Classes  ?

• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing

Goods & Services

Chemicals used in industry, science and photography, as well as in agriculture, horticulture and forestry; unprocessed artificial resins, unprocessed plastics; manures; fire extinguishing compositions; tempering and soldering preparations; chemical substances for preserving foodstuffs; tanning substances; adhesives used in industry; Laboratory and medical kits for use in research in the fields of immunological and biological research, pharmaceutical research, pre-clinical screening, and clinical trial research consisting primarily of antibodies, protein standard solutions, buffers, assay control reagents, and detection reagents. Scientific and technological services and research and design relating thereto; industrial analysis and research services; design and development of computer hardware and software; Biochemical analysis services, namely, evaluation of non-genetic biological response to disease, drugs and the environment.

Goods & Services

Chemicals used in industry, science and photography, as well as in agriculture, horticulture and forestry; unprocessed artificial resins, unprocessed plastics; manures; fire extinguishing compositions; tempering and soldering preparations; chemical substances for preserving foodstuffs; tanning substances; adhesives used in industry; laboratory and medical kits for use in research in the fields of immunological and biological research, pharmaceutical research, pre-clinical screening, and clinical trial research consisting primarily of antibodies, protein standard solutions, buffers, assay control reagents, and detection reagents. Scientific and technological services and research and design relating thereto; industrial analysis and research services; design and development of computer hardware and software; biochemical analysis services, namely, evaluation of non-genetic biological response to disease, drugs and the environment.

Goods & Services

Chemicals used in industry, science and photography, as well as in agriculture, horticulture and forestry; unprocessed artificial resins, unprocessed plastics; manures; fire extinguishing compositions; tempering and soldering preparations; chemical substances for preserving foodstuffs; tanning substances; adhesives used in industry; laboratory and medical kits for use in research in the fields of immunological and biological research, pharmaceutical research, pre-clinical screening, and clinical trial research consisting primarily of antibodies, protein standard solutions, buffers, assay control reagents, and detection reagents. Scientific and technological services and research and design relating thereto; industrial analysis and research services; design and development of computer hardware and software; biochemical analysis services, namely, evaluation of non-genetic biological response to disease, drugs and the environment.

Goods & Services

Chemicals used in industry, science and photography, as well as in agriculture, horticulture and forestry; unprocessed artificial resins, unprocessed plastics; manures; fire extinguishing compositions; tempering and soldering preparations; chemical substances for preserving foodstuffs; tanning substances; adhesives used in industry; laboratory and medical kits for use in research in the fields of immunological and biological research, pharmaceutical research, pre-clinical screening, and clinical trial research consisting primarily of antibodies, protein standard solutions, buffers, assay control reagents, and detection reagents;  none of the aforesaid goods being goods used to facilitate the designing or creation of a diagram or graphical display, including in relation to kidneys. Scientific and technological services and research and design relating thereto; industrial analysis and research services; design and development of computer hardware and software; Biochemical analysis services, namely, evaluation of non-genetic biological response to disease, drugs and the environment; none of the aforesaid services being services related to the designing or creation of a diagram or graphical display, including in relation to kidneys.

Goods & Services

Chemicals used in industry, science and photography, as well as in agriculture, horticulture and forestry; unprocessed artificial resins, unprocessed plastics; manures; fire extinguishing compositions; tempering and soldering preparations; chemical substances for preserving foodstuffs; tanning substances; adhesives used in industry; Laboratory and medical kits for use in research in the fields of immunological and biological research, pharmaceutical research, pre-clinical screening, and clinical trial research consisting primarily of antibodies, protein standard solutions, buffers, assay control reagents, and detection reagents; none of the aforesaid goods being goods used to facilitate the designing or creation of a diagram or graphical display, including in relation to inflammation. Scientific and technological services and research and design relating thereto; industrial analysis and research services; design and development of computer hardware and software; Biochemical analysis services, namely, evaluation of non-genetic biological response to disease, drugs and the environment; none of the aforesaid services related to the designing or creation of a diagram or graphical display, including in relation to inflammation.

Goods & Services

Biochemical analysis services, namely, evaluation of non-genetic biological response to disease, drugs and the environment

Goods & Services

Biochemical analysis services, namely, evaluation of non-genetic biological response to disease, drugs and the environment

Goods & Services

Biochemical analysis services, namely, evaluation of species-specific non-genetic biological response to disease, drugs and the environment.

Goods & Services

Chemicals used in industry, science and photography, as well as in agriculture, horticulture and forestry; unprocessed artificial resins, unprocessed plastics; manures; fire extinguishing compositions; tempering and soldering preparations; chemical substances for preserving foodstuffs; tanning substances; adhesives used in industry; diagnostic preparations for clinical or medical laboratory use. Scientific, nautical, surveying, photographic, cinematographic, optical, weighing, measuring, signaling, checking (supervision), life-saving and teaching apparatus and instruments; apparatus and instruments for conducting, switching, transforming, accumulating, regulating or controlling electricity; apparatus for recording, transmission or reproduction of sound or images; magnetic data carriers, recording discs; automatic vending machines and mechanisms for coin-operated apparatus; cash registers, calculating machines, data processing equipment and computers; fire-extinguishing apparatus; laboratory and medical apparatus and kits, consisting of laboratory storage tubes and cell growth reagents for use in immunological and biological research, pharmaceutical research, pre-clinical screening, and clinical trial, research and evaluation, sold together as a unit. Scientific and technological services and research and design relating thereto; industrial analysis and research services; laboratory services and laboratory testing services, relating to the examination, analysis or assaying of personal samples, biomarker testing service, biomarker assay identification.

Abstract

Methods are provided for screening for the necessity for further diagnosis of one or more diseases or conditions in a subject, which methods are based on the discovery that abnormal levels of selected analytes in a sample fluid from a subject can be correlated with specific diseases or conditions. Further provided are criteria, and methods for the determine thereof, for selected analytes with respect to selected diseases or conditions. Thus, a variety of diseases or conditions can be screened in a rapid, cost-effective composite assay. The methods are useful for screening of newborn humans for a variety of diseases and conditions, whereby additional diagnostic procedures need only be conducted for those diseases or conditions indicated by the methods of the invention.

IPC Classes  ?

• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
• G06F 19/00 - Digital computing or data processing equipment or methods, specially adapted for specific applications (specially adapted for specific functions G06F 17/00;data processing systems or methods specially adapted for administrative, commercial, financial, managerial, supervisory or forecasting purposes G06Q;healthcare informatics G16H)

Abstract

Provided are methods for the detection and diagnosis of sickle cell. The methods are based on the discovery that abnormal levels of selected analytes in sample fluid, typically blood samples, of patients who are at risk are supportive of a diagnosis of sickle cell. At least two new biomarkers for sickle cell are thus disclosed, Eotaxin and Monocyte Chemotactic Protein- 1. Altogether the concentrations of eleven analytes provide a sensitive and selective picture of the patient's condition, namely, whether the patient is suffering from sickle cell. Other important biomarkers for sickle cell are described, including but not limited to IL-12p40, SHBG, MMP-9, Adiponectin, Haptoglobin, FGF basic, IgM, Growth Hormone, Factor VII. Kits containing reagents to assist in the analysis of fluid samples are also described.

IPC Classes  ?

• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

Abstract

Provided are methods for the detection and diagnosis of galactosemia. The methods are based on the discovery that abnormal levels of selected analytes in sample fluid, typically blood samples, of patients who are at risk are supportive of a diagnosis of galactosemia. At least two new biomarkers for galactosemia are thus disclosed, Eotaxin and MCP-I. Altogether the concentrations these markers, individually, or in combinations with any of Alpha-2 Macro globulin, Apolipoprotein H, Cancer Antigen 125, Leptin, TNF RII, Alpha-Fetoprotein, IgM, MIP-I alpha, Ferritin, and IgE provide a sensitive and selective picture of the patient's condition, namely, whether the patient is suffering from galactosemia. Kits containing reagents to assist in the analysis of fluid samples are also described.

IPC Classes  ?

• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

Abstract

The present invention refers to a method for recognizing and/or characterizing cellular activity patterns, in particular for diagnostic purposes and/or for tracking the therapy of diseases. Blood cells are stimulated in a culture medium at least with toll-like receptor ligands (TLR ligands) and the stimulated blood cells and/or the culture medium are examined.

IPC Classes  ?

• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing
• C12N 5/00 - Undifferentiated human, animal or plant cells, e.g. cell linesTissuesCultivation or maintenance thereofCulture media therefor

Goods & Services

Laboratory and medical apparatus and kits, consisting of laboratory storage tubes and cell growth reagents for use in immunological and biological research, pharmaceutical research, pre-clinical screening, and clinical trial, research and evaluation, sold together as a unit

Abstract

Provided are methods for the detection and diagnosis of Hypothyroidism. The methods are based on the discovery that altered levels of selected analytes in sample fluid, typically blood samples, of patients are supportive of a diagnosis of Hypothyroidism. At least twenty-four new biomarkers for hypothyroidism are thus disclosed (singly or in any combination), Thyroid Stimulating Hormone, Interleukin- 12p40, Tumor Necrosis Factor Alpha, Tissue Factor, Interleukin-15, Insulin, Immunoglobulin E, Growth Stimulating Hormone, Calcitonin, Prostate-Specific Antigen, Interleukin-4, Granulocyte Macrophage Colony Stimulating Factor, Matrix Metalloproteinase 9, Lymphotactin, Fatty Acid Binding Protein, Alpha Fetoprotein, Alpha-2 Macroglobulin, Serum Glutamic Oxaloacetic Transaminase, Matrix Metalloproteinase 3, Cancer Antigen 125, Mumps Antibody, Double Stranded DNA Antibody, Proliferating Cell Nuclear Antigen Antibody, Smith Antibody, or Herpes Simplex Virus 1 Glycoprotein D Antibody. Altogether the concentrations of one or more of these analytes, as well as Thyroid Stimulating Hormone, or any combination thereof, provide a sensitive and selective picture of the patient's condition, namely, whether the patient is suffering from Hypothyroidism. Kits containing reagents to assist in the analysis of fluid samples are also described.

IPC Classes  ?

• G01N 33/00 - Investigating or analysing materials by specific methods not covered by groups
• G01N 33/567 - ImmunoassayBiospecific binding assayMaterials therefor using specific carrier or receptor proteins as ligand binding reagent utilising isolate of tissue or organ as binding agent

Abstract

We disclose methods and kits for measuring mat꧀x metalloproteinase 3 ('MMP-3') or serum glutamic oxaloacetic transaminase ('SGOT') concentrations in patient samples using immunoassay (e g, bead-type immunoassay, LUMINEX analyzer) Relative to the control groups, we discovered patient samples from patients with established suspicion of stroke have statistically different MMP-3 and SGOT concentrations Thus, our methods and kits find use in supporting a positive diagnosis of stroke.

IPC Classes  ?

• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• G06F 17/18 - Complex mathematical operations for evaluating statistical data

Abstract

The invention relates to a drilled well (1) which is adapted to extract groundwater. Said well comprises a well pipework (4) installed in a borehole of a rock formation (2) and a filter unit (5) provided at the lower end of the well pipework (4), said filter unit (5) having at least one filter element (6). In a state of extraction, at least the filter element (6) is embedded in a filter bed (9) from a filter material installed in the area of the borehole bottom (7) in the annular space between the filter unit (5) and the borehole walls (8). The invention is characterized in that in order to remove the filter bed (9), at least one guide conduit (10) and at least one flushing conduit (11) are provided. The guide conduit (10) and the flushing conduit (11) extend inside the borehole from the surface of the rock formation (2) at least down to the depth of the filter element (6). The guide conduit (10) comprises at least one conduit opening (13, 14) and the flushing conduit (11) at least one exit opening (12) in the area of the filter bed (9). The exit opening (12) is arranged in relation to the conduit opening (13, 14) in such a manner that the filter material is at least partially entrained by the flushing medium (15) penetrating the flushing conduit (11), enters the guide conduit (10) via the conduit opening (13, 14) and is discharged from the borehole together with the flushing medium (15) through the guide conduit (10).

Goods & Services

Biochemical analysis services, namely, evaluation of species-specific non-genetic biological response to disease, drugs and the environment