De Keijzer, Adrianus, Hendricus, Joseph, Franciscus
Nijbacker, Tom
Abstract
The present invention provides a system, comprising at least one reactor array, comprising at least two reactor vessels (2) a connecting member for fixating the at least two reactor vessels relative to each other (4, 5) at least one reactor block (18) comprising a heating block (20) for heating the reactor vessels (2) the heating block (20) comprising at least two reactor channels for receiving the at least two reactor vessels (2) wherein the heating block (20) is constructed of a material having a thermal expansion coefficient ឬ=lxl0e-5 K-I (at 293K). In an embodiment the heating block is substantially entirely constructed of graphite.
The invention relates to a laboratory degradation test system for testing degradation of a test specimen in a test fluid flow, the test system comprising: - a reactor assembly, which reactor assembly comprises: - a reactor vessel, the reactor vessel having a reaction space, an inlet and an outlet and a specimen holder for retaining a test specimen inside the reactor vessel, - a heater for heating the reactor vessel, - a fluid circulation system generating a test fluid flow over the test specimen, which fluid circulation system comprises: - a circulation line which extends between the outlet of the reactor vessel and the inlet of the reactor vessel, which circulation line is arranged outside the reactor vessel, - a pump for providing fluid circulation through the circulation line and the reactor vessel, which pump is arranged in the circulation line. The laboratory test system according to the invention is characterised in that the volume available to the test fluid inside the reaction space after insertion of the degradation test specimen is less than or equal to 10 ml.
The invention comprises a method to derive a composition of a sample of a plurality of samples. Each sample comprises at least one substance of a plurality of substances. In a first step a diffraction pattern measurement is performed on each sample of the plurality of samples to obtain a plurality of diffraction patterns. Further, in the plurality of diffraction patterns correlations between the properties in the diffraction patterns and grouping the diffraction patterns based on the determined correlations are determined. Still further, a subset of the diffraction patterns is selected, the subset comprising diffraction patterns from each of the groups. Diffraction patterns of pure forms of the substances are estimated, which comprises determining an estimate of diffraction patterns of the pure forms of the substances, determining estimated diffraction patterns by relating the diffraction patterns of the subset with patterns reconstructed using the estimated diffraction patterns, given estimates of the concentrations of each of the substances, estimating concentration profiles of the subset of diffraction patterns by relating the diffraction patterns of the subset with patterns reconstructed using the estimated diffraction patterns, given estimates of the diffraction patterns of the pure forms. Also, the method comprises fitting the obtained diffraction patterns of pure forms of the substances with the diffraction patterns of the samples to determine which of the substances is present in each of the samples.
G01N 23/20 - Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups , or by using diffraction of the radiation by the materials, e.g. for investigating crystal structureInvestigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups , or by using scattering of the radiation by the materials, e.g. for investigating non-crystalline materialsInvestigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups , or by using reflection of the radiation by the materials
Method for the preparation of a co-crystal from an Active Pharmaceutical Ingredient (API) and a co-moiety by providing a molecular model representing at least a part of the physical and chemical properties of the API; providing a molecular model for each of a set of known co-moieties representing at least a part of the physical and chemical properties of each respective co-moiety; for each co-moiety in the set of step (b), determining whether at least one hydrogen-bond between the ACI molecule and the co-moiety is possible by comparing the molecular model of the ACI molecule as provided in step (a) and the molecular model of the co-moiety as provided in step (b); and excluding any co-moiety not capable of hydrogen-bonding with the ACI molecule, thereby obtaining a set of hydrogen-bonding co-moieties, selecting a suitable solvent and performing a set of experiments providing co-crystals of the API.
G06F 19/00 - Digital computing or data processing equipment or methods, specially adapted for specific applications (specially adapted for specific functions G06F 17/00;data processing systems or methods specially adapted for administrative, commercial, financial, managerial, supervisory or forecasting purposes G06Q;healthcare informatics G16H)
5.
METHOD FOR OBTAINING AND ANALYZING SOLIDS, PREFERABLY CRYSTALS
De Keijzer, Adrianus, Hendricus, Joseph, Franciscus
Bodenstaff, Emilio, René
Lamkadmi, Mimoun
Abstract
The present invention pertains to a method for obtaining and analyzing solids, preferably crystals, which method comprises the following steps: - providing a well plate, the well plate comprising a plurality of wells, each of the wells having a depth and an open upper end and each of the wells being provided with a filter having pores, which filter is arranged at a distance below the open upper end, each of the wells having an upper inner wall part above the filter that has a fluid contact surface and each filter having a top filter surface, at least both the fluid contact surface of the well and the top filter surface being of a material that is at least substantially inert for organic and/or aqueous solvents and/or mixtures of organic and aqueous solvents. - providing one or more substances and one or more solvents in at least one of the wells of the well plate, - applying conditions to dissolve the one or more substances in the one or more solvents; - applying conditions for crystallizing at least a part of the substance so that solids are formed in the at least one well, - substantially removing the part of the substance that remains in solution, thereby leaving the solids, preferably crystals, that were formed from the substance in the well of the well plate in which they were formed, - performing further investigation of the solids, preferably crystals in the well of the well plate where they were formed.
G01N 23/20 - Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups , or by using diffraction of the radiation by the materials, e.g. for investigating crystal structureInvestigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups , or by using scattering of the radiation by the materials, e.g. for investigating non-crystalline materialsInvestigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups , or by using reflection of the radiation by the materials
A system for determining a solubility of a substance comprises a holder to hold a sample comprising an amount of the substance and an amount of the solvent system. The system further comprises a temperature conditioner to alter a temperature of the sample, an optical measurement device to measure an optical parameter of the sample and a control device to control at least the temperature conditioner and the optical measurement device. The control device may be programmed to alter the temperature of the sample by the temperature conditioner, measure the optical parameter of the sample by the optical measurement device, and determine the solubility of the substance from a change of the optical parameter of the sample as a function of the temperature.
G01N 25/14 - Investigating or analysing materials by the use of thermal means by using distillation, extraction, sublimation, condensation, freezing, or crystallisation
G01N 25/06 - Analysis by measuring change of freezing point
G01N 21/53 - Scattering, i.e. diffuse reflection within a body or fluid within a flowing fluid, e.g. smoke
patents