Provided is a novel gummy edible composition prepared using hyaluronic acid as a gelatinizing agent. The gummy edible composition comprises hyaluronic acid, a sugar (provided that a liquid polyhydric alcohol that has a liquid form at 25℃ is excluded), an acid that is different from the hyaluronic acid, and water, in which the molecular weight of the hyaluronic acid is 2.0×105daltons to 1.6×106 daltons inclusive, the content of the sugar is 8 parts by mass to 35 parts by mass inclusive relative to 1 part by mass of the hyaluronic acid, and the content of the water is 10% by mass to 25% by mass inclusive.
In this water-soluble hyaluronic acid gel production method, a water-soluble hyaluronic acid gel is provided which can be produced with high productivity and without the need for a step for evaporating a large amount of water from a hyaluronic acid solution. This water-soluble hyaluronic acid gel contains hyaluronic acid, water-soluble dietary fibers, an acid other than hyaluronic acid, and water, wherein: the water-soluble dietary fibers are polysaccharides that have glucose as the constituent sugar, contain bonds other than 1-4 bonds and 1-6 bonds, and do not have a cyclic structure; the water content is 1-300 parts by mass per 1 part by mass of the hyaluronic acid; and the content of the water-soluble dietary fibers is 1-300 parts by mass per 1 part by mass of the hyaluronic acid.
Provided is a novel oral mucosa application material that has good handling properties, has excellent application properties for being applied to the oral mucosa even if moisture or saliva on the surface of the oral mucosa is heavy, and is provided with a property for improving the effect of physically protecting an application site by containing the moisture or saliva after application and showing elasticity, and further, a property for remaining at the application site for a long time. This oral mucosa application material is provided with a freeze-dried body containing a polymer on an adhesion surface to the oral mucosa. The content of the polymer in the freeze-dried body is 20 mass % or more, and the content of hyaluronic acid in the polymer is 50 mass % or more.
Provided is a novel pharmaceutical formulation that has excellent storage stability and can be suitably used, for example, in hyposensitization therapy. This pharmaceutical formulation is provided with a lyophilized composition containing at least an allergen protein and hyaluronic acid.
Provided is a novel oral mucosa application material that has good handling properties, has excellent application properties for being applied to the oral mucosa even if moisture or saliva on the surface of the oral mucosa is heavy, and is provided with a property for improving the effect of physically protecting an application site by containing the moisture or saliva after application and showing elasticity, and further, a property for remaining at the application site for a long time. This oral mucosa application material is provided with a freeze-dried body containing a polymer on an adhesion surface to the oral mucosa. The content of the polymer in the freeze-dried body is 20% by mass or more, and the content of hyaluronic acid in the polymer is 50% by mass or more.
Provided is a water-soluble hyaluronic acid gel that is in a highly stable gel form even at a low temperature, despite being substantially free from any gel-forming component other than hyaluronic acid and containing a saccharide (excluding a liquid polyhydric alcohol being liquid at 25°C). The water-soluble hyaluronic acid gel comprising hyaluronic acid, a saccharide (excluding a liquid polyhydric alcohol being liquid at 25°C) and water, wherein: the moisture content thereof exceeds 30 mass%; the water-soluble hyaluronic acid gel is substantially free from any gel-forming component other than hyaluronic acid; and the pH value of an aqueous solution thereof is within the range of 1.9-6.3, said pH value being measured by the following method. (Method for pH measurement) In the aforesaid water-soluble hyaluronic acid gel in an amount of containing 1 g of hyaluronic acid, all ionic components excluding water are dissolved in water and the volume is made up to 200 ml to thereby prepare an aqueous solution. Then, the pH value of the obtained aqueous solution is measured.
A23L 29/269 - Foods or foodstuffs containing additivesPreparation or treatment thereof containing gelling or thickening agents of microbial origin, e.g. xanthan or dextran
A23L 29/275 - Foods or foodstuffs containing additivesPreparation or treatment thereof containing gelling or thickening agents of animal origin, e.g. chitin
Provided is a water-soluble hyaluronic acid gel that is in the form of a gel regardless of substantially containing no gel-forming component other than hyaluronic acid. The water-soluble hyaluronic acid gel comprises hyaluronic acid, a saccharide (excluding a liquid polyhydric alcohol existing as a liquid at 25°C) and water, wherein the content of water is not more than 15 parts by mass per part by mass of hyaluronic acid, and substantially no gel-forming component other than hyaluronic acid is contained.
A23L 29/269 - Foods or foodstuffs containing additivesPreparation or treatment thereof containing gelling or thickening agents of microbial origin, e.g. xanthan or dextran
A23L 29/275 - Foods or foodstuffs containing additivesPreparation or treatment thereof containing gelling or thickening agents of animal origin, e.g. chitin
Provided is a water-soluble hyaluronic acid gel which is suitably gelled by a hyaluronic acid even though a polyhydric alcohol is not substantially contained therein. A water-soluble hyaluronic acid gel which contains a hyaluronic acid, 10-160 parts by mass of water per 1 part by mass of the hyaluronic acid, and an acid other than hyaluronic acids, and an aqueous solution of which has a pH within the range of 2.2-3.4 as measured by the measurement method below. (Measurement method of pH) An aqueous solution is obtained by dissolving all the ionic components other than water among the components contained in the water-soluble hyaluronic acid gel that contains 1g of the hyaluronic acid into water so that the resulting aqueous solution amounts to 200 mL, and the pH of the thus-obtained aqueous solution is measured.
Provided is a water-soluble hyaluronic acid gel which can be properly gelated despite containing a large amount of honey. This water-soluble hyaluronic acid gel contains hyaluronic acid, honey, another acid other than hyaluronic acid, and at least one from among water and polyhydric alcohol, wherein the honey content is 5 parts by mass or more with respect to 1 part by mass of the hyaluronic acid.
A61K 8/98 - Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof, of undetermined constitution of animal origin
A61K 9/00 - Medicinal preparations characterised by special physical form
A61K 47/36 - PolysaccharidesDerivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
A61K 47/46 - Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
Provided is a water-soluble hyaluronic acid gel in which water-soluble crystalline sugar is present in a dissolved state. The water-soluble hyaluronic acid gel contains hyaluronic acid, water-soluble crystalline sugar, water, and an acid other than hyaluronic acid. The water content of the water-soluble hyaluronic acid gel is 50 mass% or more of the amount necessary to prepare a saturated aqueous solution of the water-soluble crystalline sugar.
[Problem] To provide a water-soluble hyaluronic acid gel which does not contain a large amount of an organic solvent, and wherein hyaluronic acid is not chemically modified. [Solution] A water-soluble hyaluronic acid gel which contains hyaluronic acid, a polyhydric alcohol, an acid, and 0-10% by mass of a water-soluble organic solvent.
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