Rapid Micro Biosystems, Inc.

United States of America

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IPC Class
C12Q 1/04 - Determining presence or kind of microorganismUse of selective media for testing antibiotics or bacteriocidesCompositions containing a chemical indicator therefor 20
C12M 1/00 - Apparatus for enzymology or microbiology 16
C12M 1/34 - Measuring or testing with condition measuring or sensing means, e.g. colony counters 15
C12M 1/22 - Petri dishes 14
C12M 1/12 - Apparatus for enzymology or microbiology with sterilisation, filtration, or dialysis means 9
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Registered / In Force 28
Found results for  patents

1.

RINSE SOLUTION FOR MICROBIAL DETECTION SYSTEMS

      
Application Number US2024054368
Publication Number 2025/101448
Status In Force
Filing Date 2024-11-04
Publication Date 2025-05-15
Owner RAPID MICRO BIOSYSTEMS, INC. (USA)
Inventor
  • Griffin, Frank Owen
  • Rodriguez Santana, Juan Pablo
  • Russell, Courtney
  • Jones, David

Abstract

Exemplary embodiments pertain to a solution containing carbon black. The solution may be applied to a membrane filter of a microbial enumeration system as a post-rinse solution (i.e., after the membrane filter is rinsed with the sample of interest). The solution may reduce or suppress background autofluorescence, thereby improving detection and enumeration of colony forming units (CFUs) or other microbiological entities. The solution may be used in connection with a method for performing sample preparation for a microbial enumeration system. The carbon black solution may be manufactured according to a manufacturing process detailed herein.

IPC Classes  ?

  • C12Q 1/04 - Determining presence or kind of microorganismUse of selective media for testing antibiotics or bacteriocidesCompositions containing a chemical indicator therefor
  • C12M 1/34 - Measuring or testing with condition measuring or sensing means, e.g. colony counters
  • C09C 1/48 - Carbon black
  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
  • G01N 21/64 - FluorescencePhosphorescence
  • G01N 1/38 - Diluting, dispersing or mixing samples
  • G01N 21/62 - Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light

2.

RINSE SOLUTION FOR MICROBIAL DETECTION SYSTEMS

      
Application Number 18936099
Status Pending
Filing Date 2024-11-04
First Publication Date 2025-05-08
Owner RAPID MICRO BIOSYSTEMS, INC. (USA)
Inventor
  • Griffin, Owen
  • Rodriguez Santana, Juan Pablo
  • Russell, Courtney
  • Jones, David

Abstract

Exemplary embodiments pertain to a solution containing carbon black. The solution may be applied to a membrane filter of a microbial enumeration system as a post-rinse solution (i.e., after the membrane filter is rinsed with the sample of interest). The solution may reduce or suppress background autofluorescence, thereby improving detection and enumeration of colony forming units (CFUs) or other microbiological entities. The solution may be used in connection with a method for performing sample preparation for a microbial enumeration system. The carbon black solution may be manufactured according to a manufacturing process detailed herein.

IPC Classes  ?

  • C12Q 1/04 - Determining presence or kind of microorganismUse of selective media for testing antibiotics or bacteriocidesCompositions containing a chemical indicator therefor

3.

STERILITY TESTING DRAIN ACTUATOR BASE

      
Application Number 18464066
Status Pending
Filing Date 2023-09-08
First Publication Date 2025-03-13
Owner RAPID MICRO BIOSYSTEMS, INC. (USA)
Inventor
  • Isaacs, Toby
  • Franco, Ethan
  • Chung, Victor

Abstract

Exemplary embodiments relate to drain actuators for cassettes used in sterility testing. A sterility cassette may have a spring-loaded drain to allow fluid flow through a porous membrane. To activate the drain, upwards pressure is applied to the spring during kit preparation through an actuator base. The actuator base may automatically actuate the drain when the cassette is inserted into the actuator base, and may be separate from or integral with a thermoformed drain tray. When the sterility cassette is removed from the tray, the base automatically shuts the drain. The actuator base has features that: maintain the rotational alignment between the tray and cassette; actuate the drain port on the bottom of the cassette; minimally inhibit flow out of the drain; minimize the collection of drain fluid; provide a rigid support across the drain tray surface; and stay locked into the drain tray when the cassette is removed.

IPC Classes  ?

  • A61L 2/28 - Devices for testing the effectiveness or completeness of sterilisation, e.g. indicators which change colour

4.

STERILITY TESTING DRAIN ACTUATOR BASE

      
Application Number US2024045498
Publication Number 2025/054400
Status In Force
Filing Date 2024-09-06
Publication Date 2025-03-13
Owner RAPID MICRO BIOSYSTEMS, INC. (USA)
Inventor
  • Isaacs, Toby
  • Franco, Ethan
  • Chung, Victor

Abstract

Exemplary embodiments relate to drain actuators for cassettes used in sterility testing. A sterility cassette may have a spring-loaded drain to allow fluid flow through a porous membrane. To activate the drain, upwards pressure is applied to the spring during kit preparation through an actuator base. The actuator base may automatically actuate the drain when the cassette is inserted into the actuator base, and may be separate from or integral with a thermoformed drain tray. When the sterility cassette is removed from the tray, the base automatically shuts the drain. The actuator base has features that: maintain the rotational alignment between the tray and cassette; actuate the drain port on the bottom of the cassette; minimally inhibit flow out of the drain; minimize the collection of drain fluid; provide a rigid support across the drain tray surface; and stay locked into the drain tray when the cassette is removed.

IPC Classes  ?

  • C12M 1/00 - Apparatus for enzymology or microbiology

5.

CELL CULTURING DEVICE

      
Application Number 18829586
Status Pending
Filing Date 2024-09-10
First Publication Date 2025-02-06
Owner RAPID MICRO BIOSYSTEMS, INC. (USA)
Inventor
  • Browne, Douglas J.
  • Karakozian, Sarkis
  • Chen, Xiaowei

Abstract

The invention features devices and kits for capturing and culturing microorganisms (e.g., bacteria, fungi, or protists) and methods of using the devices and kits to detect microorganisms in environmental and other samples. The device includes a nutrient media having a flat growth area on which microorganisms can grow. Samples are collected by contacting the device with any environmental sample, e.g., rolling device on a work surface or exposing device to air, or by filtering a sample through a membrane. Microorganisms deposited on the membrane derive nutrients from the underlying media and grow into colonies that can then be detected using methods known in the art. The detected colonies can be imaged digitally or with film.

IPC Classes  ?

  • C12Q 1/04 - Determining presence or kind of microorganismUse of selective media for testing antibiotics or bacteriocidesCompositions containing a chemical indicator therefor
  • C12M 1/00 - Apparatus for enzymology or microbiology
  • C12M 1/22 - Petri dishes

6.

METHODS AND SYSTEMS FOR DETECTING AN ORIENTATION OF A CASSETTE

      
Application Number 18747382
Status Pending
Filing Date 2024-06-18
First Publication Date 2024-12-26
Owner RAPID MICRO BIOSYSTEMS, INC. (USA)
Inventor
  • Wilt, Michael
  • Silvestre, Celso
  • Howe, Kyle
  • Tia, Peter

Abstract

Exemplary embodiments pertain to an automated sample processing system that includes a cassette having a superior component and an inferior component, where the superior component and the inferior component have a sufficient delta in opacity that is detectable by a sensor. An emitter is configured to emit a signal, where the signal passes laterally through one component of the cassette (or is diffused by it) and is configured to be received by a sensor. The sensor is configured to communicate the signal processing logic that is configured to interpret the signal and indicate the orientation of the cassette. Also disclosed is a method of detecting the orientation of a cassette in the automated sample processing system.

IPC Classes  ?

  • G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups Handling materials therefor
  • G01N 35/02 - Automatic analysis not limited to methods or materials provided for in any single one of groups Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations

7.

METHODS AND SYSTEMS FOR DETECTING AN ORIENTATION OF A CASSETTE

      
Application Number US2024034553
Publication Number 2024/263603
Status In Force
Filing Date 2024-06-18
Publication Date 2024-12-26
Owner RAPID MICRO BIOSYSTEMS, INC. (USA)
Inventor
  • Wilt, Michael
  • Silvestre, Celso
  • Howe, Kyle
  • Tia, Peter

Abstract

Exemplary embodiments pertain to an automated sample processing system that includes a cassette having a superior component and an inferior component, where the superior component and the inferior component have a sufficient delta in opacity that is detectable by a sensor. An emitter is configured to emit a signal, where the signal passes laterally through one component of the cassette (or is diffused by it) and is configured to be received by a sensor. The sensor is configured to communicate the signal processing logic that is configured to interpret the signal and indicate the orientation of the cassette. Also disclosed is a method of detecting the orientation of a cassette in the automated sample processing system.

IPC Classes  ?

  • G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups Handling materials therefor
  • G01N 35/04 - Details of the conveyor system
  • G01N 15/00 - Investigating characteristics of particlesInvestigating permeability, pore-volume or surface-area of porous materials
  • C12M 1/34 - Measuring or testing with condition measuring or sensing means, e.g. colony counters

8.

SPLASHGUARD AND CASSETTE ASSEMBLY FOR STERILITY TESTING

      
Application Number US2023082875
Publication Number 2024/129499
Status In Force
Filing Date 2023-12-07
Publication Date 2024-06-20
Owner RAPID MICRO BIOSYSTEMS, INC. (USA)
Inventor
  • Black, Hunter
  • Lefort, David
  • Blaisdell, John
  • Sauer-Budge, Alexis
  • Kreuzer, Steven
  • Gilman, Lindsey
  • Morad, Blair

Abstract

Membrane filtration is a technique for performing sterility testing on products, in which a sample is introduced to a sterile environment (such as a cassette) through an inlet port and then passed through one or more filters. The samples may be pumped into the cassette at a relatively high pressure, which can cause the sample to spray, mist, or foam. When the sample sprays in this manner, it can cause inconsistent results and can obscure the view through the lid of the cassette, which makes it difficult to analyze the incubated media. Exemplary embodiments provide a unique splash guard sized and shaped to transition the incoming sample fluids from a high-pressure state to a lower pressure flow. Consequently, the fluid flows more smoothly into the cassette which yields more consistent and accurate results.

IPC Classes  ?

  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers

9.

TUBE SET WITH DUAL PRESSURE REGULATING VALVE

      
Application Number US2023083762
Publication Number 2024/129814
Status In Force
Filing Date 2023-12-13
Publication Date 2024-06-20
Owner RAPID MICRO BIOSYSTEMS, INC. (USA)
Inventor
  • Morad, Blair
  • Franco, Ethan

Abstract

A microbe enumeration kit or system is provided that includes a number of cassettes with an upper and lower chamber separated by a membrane. The kit further includes a media reservoir fluidly coupled to the cassettes by a tube set and a dual pressure valve mechanically coupled to the tube set and arranged to change a pressure in the cassettes to cause fluid from the fluid reservoir to pass through or interact with the membrane.

IPC Classes  ?

  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
  • C12M 1/00 - Apparatus for enzymology or microbiology

10.

TUBE SET WITH DUAL PRESSURE REGULATING VALVE

      
Application Number 18538085
Status Pending
Filing Date 2023-12-13
First Publication Date 2024-06-13
Owner RAPID MICRO BIOSYSTEMS, INC. (USA)
Inventor
  • Morad, Blair
  • Franco, Ethan

Abstract

A microbe enumeration kit or system is provided that includes a number of cassettes with an upper and lower chamber separated by a membrane. The kit further includes a media reservoir fluidly coupled to the cassettes by a tube set and a dual pressure valve mechanically coupled to the tube set and arranged to change a pressure in the cassettes to cause fluid from the fluid reservoir to pass through or interact with the membrane.

IPC Classes  ?

  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers

11.

SPLASHGUARD AND CASSETTE ASSEMBLY FOR STERILITY TESTING

      
Application Number 18065247
Status Pending
Filing Date 2022-12-13
First Publication Date 2024-06-13
Owner RAPID MICRO BIOSYSTEMS, INC. (USA)
Inventor
  • Black, Hunter
  • Lefort, David
  • Blaisdell, John
  • Sauer-Budge, Alexis
  • Kreuzer, Steven
  • Gilman, Lindsey
  • Morad, Blair

Abstract

Membrane filtration is a technique for performing sterility testing on products, in which a sample is introduced to a sterile environment (such as a cassette) through an inlet port and then passed through one or more filters. The samples may be pumped into the cassette at a relatively high pressure, which can cause the sample to spray, mist, or foam. When the sample sprays in this manner, it can cause inconsistent results and can obscure the view through the lid of the cassette, which makes it difficult to analyze the incubated media. Exemplary embodiments provide a unique splash guard sized and shaped to transition the incoming sample fluids from a high-pressure state to a lower pressure flow. Consequently, the fluid flows more smoothly into the cassette which yields more consistent and accurate results.

IPC Classes  ?

  • G01N 15/06 - Investigating concentration of particle suspensions

12.

CUTTING SUBASSEMBLY AND CONDITIONING ASSEMBLY FOR AN ENVIRONMENT

      
Application Number US2023075946
Publication Number 2024/077064
Status In Force
Filing Date 2023-10-04
Publication Date 2024-04-11
Owner RAPID MICRO BIOSYSTEMS, INC. (USA)
Inventor
  • Black, Hunter
  • Lefort, David
  • Morad, Blair
  • Chung, Victor
  • Beach, Kaitlin
  • Martin, Jason
  • Griffin, Frank Owen
  • Franco, Ethan
  • Volis, Kayla
  • Isaacs, Toby
  • Paradis, Taylor

Abstract

This application relates to improvements in environments for microbial testing. Exemplary embodiments provide a uniquely configured tray containing an environment conditioning material, such as an oxygen scavenger material, for use with a cassette assembly. Furthermore, some embodiments provide a cutting mechanism that allows the tray to be reliably breached, thereby exposing the material inside to the environment. Some embodiments can cut open the material with specially-configured cutter teeth, which can easily be deployed by twisting or pushing two halves of the cassette assembly.

IPC Classes  ?

  • C12M 3/00 - Tissue, human, animal or plant cell, or virus culture apparatus
  • C12M 1/34 - Measuring or testing with condition measuring or sensing means, e.g. colony counters

13.

CUTTING SUBASSEMBLY AND CONDITIONING ASSEMBLY FOR AN ENVIRONMENT

      
Application Number US2023075947
Publication Number 2024/077065
Status In Force
Filing Date 2023-10-04
Publication Date 2024-04-11
Owner RAPID MICRO BIOSYSTEMS, INC. (USA)
Inventor
  • Black, Hunter
  • Lefort, David
  • Morad, Blair
  • Chung, Victor
  • Beach, Kaitlin
  • Martin, Jason
  • Griffin, Frank Owen
  • Franco, Ethan
  • Volis, Kayla
  • Isaacs, Toby
  • Paradis, Taylor

Abstract

This application relates to improvements in environments for microbial testing. Exemplary embodiments provide a uniquely configured tray containing an environment conditioning material, such as an oxygen scavenger material, for use with a cassette assembly. Furthermore, some embodiments provide a cutting mechanism that allows the tray to be reliably breached, thereby exposing the material inside to the environment. Some embodiments can cut open the material with specially-configured cutter teeth, which can easily be deployed by twisting or pushing two halves of the cassette assembly.

IPC Classes  ?

  • C12M 3/00 - Tissue, human, animal or plant cell, or virus culture apparatus
  • C12M 1/34 - Measuring or testing with condition measuring or sensing means, e.g. colony counters

14.

CUTTING SUBASSEMBLY AND CONDITIONING ASSEMBLY FOR AN ENVIRONMENT

      
Application Number 18514724
Status Pending
Filing Date 2023-11-20
First Publication Date 2024-04-04
Owner RAPID MICRO BIOSYSTEMS, INC. (USA)
Inventor
  • Black, Hunter
  • Lefort, David
  • Morad, Blair
  • Chung, Victor
  • Beach, Kaitlin
  • Martin, Jason
  • Griffin, Frank Owen
  • Franco, Ethan
  • Volis, Kayla
  • Isaacs, Toby
  • Paradis, Taylor

Abstract

This application relates to improvements in environments for microbial testing. Exemplary embodiments provide a uniquely configured tray containing an environment conditioning material, such as an oxygen scavenger material, for use with a cassette assembly. Furthermore, some embodiments provide a cutting mechanism that allows the tray to be reliably breached, thereby exposing the material inside to the environment. Some embodiments can cut open the material with specially-configured cutter teeth, which can easily be deployed by twisting or pushing two halves of the cassette assembly.

IPC Classes  ?

  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
  • C12M 1/32 - Inoculator or sampler multiple field or continuous type
  • C12Q 1/04 - Determining presence or kind of microorganismUse of selective media for testing antibiotics or bacteriocidesCompositions containing a chemical indicator therefor

15.

CUTTING SUBASSEMBLY AND CONDITIONING ASSEMBLY FOR AN ENVIRONMENT

      
Application Number 18480853
Status Pending
Filing Date 2023-10-04
First Publication Date 2024-04-04
Owner RAPID MICRO BIOSYSTEMS, INC. (USA)
Inventor
  • Black, Hunter
  • Lefort, David
  • Morad, Blair
  • Chung, Victor
  • Beach, Kaitlin
  • Martin, Jason
  • Griffin, Frank Owen
  • Franco, Ethan
  • Volis, Kayla
  • Isaacs, Toby
  • Paradis, Taylor

Abstract

This application relates to improvements in environments for microbial testing. Exemplary embodiments provide a uniquely configured tray containing an environment conditioning material, such as an oxygen scavenger material, for use with a cassette assembly. Furthermore, some embodiments provide a cutting mechanism that allows the tray to be reliably breached, thereby exposing the material inside to the environment. Some embodiments can cut open the material with specially-configured cutter teeth, which can easily be deployed by twisting or pushing two halves of the cassette assembly.

IPC Classes  ?

  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
  • C12M 1/32 - Inoculator or sampler multiple field or continuous type
  • C12Q 1/04 - Determining presence or kind of microorganismUse of selective media for testing antibiotics or bacteriocidesCompositions containing a chemical indicator therefor

16.

CASSETTE FOR STERILITY TESTING

      
Application Number 18463595
Status Pending
Filing Date 2023-09-08
First Publication Date 2023-12-28
Owner RAPID MICRO BIOSYSTEMS, INC. (USA)
Inventor
  • Aviles, Robert C.
  • Michaud, Devin T.
  • Browne, Douglas J.

Abstract

The invention provides a device for growing cells—referred to as a cassette. The cell culturing device includes a housing that contains a lid having an optically clear window; a fluid distribution channel; a sample injection port fluidically connected to the fluid distribution channel; a base housing a porous media pad; and a media injection port fluidically connected to the media pad. The lid mates to the base to form a sterile seal; the fluid distribution channel is disposed over the media pad, which is viewable through the optical window; and sample fluid introduced into the fluid distribution channel is distributed evenly to the media pad, e.g., via a plurality of channels. The invention also provides kits that include cassettes of the invention and a tube set.

IPC Classes  ?

  • C12M 3/00 - Tissue, human, animal or plant cell, or virus culture apparatus
  • C12M 1/00 - Apparatus for enzymology or microbiology
  • C12M 1/22 - Petri dishes
  • C12M 1/12 - Apparatus for enzymology or microbiology with sterilisation, filtration, or dialysis means
  • C12M 1/26 - Inoculator or sampler
  • C12M 1/34 - Measuring or testing with condition measuring or sensing means, e.g. colony counters
  • C12Q 1/22 - Testing for sterility conditions

17.

MICROBIOLOGICAL GROWTH MEDIA AND METHODS OF USING THE SAME

      
Application Number 18333957
Status Pending
Filing Date 2023-06-13
First Publication Date 2023-10-12
Owner RAPID MICRO BIOSYSTEMS, INC. (USA)
Inventor
  • Shara, Kate
  • Schwedock, Julie
  • Vogel, Sommer

Abstract

The present invention features general-purpose microbiological growth media capable of supporting growth of microorganisms on membranes. The media contain casein digest, soybean digest, animal tissue digest, yeast extract, dextrose, a phosphate buffer, hemin, and L-cystine. The invention features an all-purpose microbiological growth media that can support the growth of anaerobes, molds, injured spores, and general aerobic bacteria to a greater extent than other media.

IPC Classes  ?

  • C12N 1/20 - BacteriaCulture media therefor
  • C12N 1/14 - Fungi Culture media therefor
  • C12Q 1/04 - Determining presence or kind of microorganismUse of selective media for testing antibiotics or bacteriocidesCompositions containing a chemical indicator therefor
  • C12N 1/38 - Chemical stimulation of growth or activity by addition of chemical compounds which are not essential growth factorsStimulation of growth by removal of a chemical compound
  • C12N 1/16 - YeastsCulture media therefor

18.

Cell culturing device

      
Application Number 18311383
Grant Number 12091703
Status In Force
Filing Date 2023-05-03
First Publication Date 2023-08-31
Grant Date 2024-09-17
Owner RAPID MICRO BIOSYSTEMS, INC. (USA)
Inventor
  • Browne, Douglas J.
  • Karakozian, Sarkis
  • Chen, Xiaowei

Abstract

The invention features devices and kits for capturing and culturing microorganisms (e.g., bacteria, fungi, or protists) and methods of using the devices and kits to detect microorganisms in environmental and other samples. The device includes a nutrient media having a flat growth area on which microorganisms can grow. Samples are collected by contacting the device with any environmental sample, e.g., rolling device on a work surface or exposing device to air, or by filtering a sample through a membrane. Microorganisms deposited on the membrane derive nutrients from the underlying media and grow into colonies that can then be detected using methods known in the art. The detected colonies can be imaged digitally or with film.

IPC Classes  ?

  • C12Q 1/04 - Determining presence or kind of microorganismUse of selective media for testing antibiotics or bacteriocidesCompositions containing a chemical indicator therefor
  • C12M 1/00 - Apparatus for enzymology or microbiology
  • C12M 1/22 - Petri dishes

19.

FILTRATION ASSEMBLIES, CASSETTES, SYSTEMS, AND METHODS FOR FILTRATION AND CELL GROWTH

      
Application Number 18004589
Status Pending
Filing Date 2021-07-08
First Publication Date 2023-08-17
Owner RAPID MICRO BIOSYSTEMS, INC. (USA)
Inventor
  • Rippeth, John
  • Wehebrink, Max
  • Tyldesley, Frank
  • Smith, Richard

Abstract

The present invention features filtration assemblies, cassettes, systems, and methods for filtering cells from a sample solution and then incubating the captured cells.

IPC Classes  ?

  • C12M 1/26 - Inoculator or sampler
  • C12Q 1/24 - Methods of sampling, or inoculating or spreading a sampleMethods of physically isolating an intact microorganism
  • C12M 1/00 - Apparatus for enzymology or microbiology
  • C12M 3/00 - Tissue, human, animal or plant cell, or virus culture apparatus

20.

ATTENUATED-BACKGROUND MICROBIOLOGICAL NUTRIENT MEDIA AND METHODS OF USING THE SAME

      
Application Number 17918185
Status Pending
Filing Date 2021-04-15
First Publication Date 2023-04-27
Owner RAPID MICRO BIOSYSTEMS, INC. (USA)
Inventor
  • Barra, Jessica Tse
  • Rodriguez Santana, Juan Pablo
  • Grabar, Tammy Bohannon
  • Rippeth, John
  • Noble, Michael
  • Hughes, Gwilym

Abstract

The present invention features microbiological nutrient media capable of supporting growth of microorganisms. The medium includes a gelling agent and a dye and/or pigment that reduces background.

IPC Classes  ?

  • C12Q 1/04 - Determining presence or kind of microorganismUse of selective media for testing antibiotics or bacteriocidesCompositions containing a chemical indicator therefor

21.

RAPID DETECTION OF REPLICATING CELLS

      
Application Number 18045897
Status Pending
Filing Date 2022-10-12
First Publication Date 2023-03-16
Owner RAPID MICRO BIOSYSTEMS, INC. (USA)
Inventor Straus, Don

Abstract

The invention enables efficient, rapid, and sensitive enumeration of living cells by detecting microscopic colonies derived from in situ cell division using large area imaging. Microbial enumeration tests based on the invention address an important problem in clinical and industrial microbiology—the long time needed for detection in traditional tests—while retaining key advantages of the traditional methods based on microbial culture. Embodiments of the invention include non-destructive aseptic methods for detecting cellular microcolonies without labeling reagents. These methods allow for the generation of pure cultures which can be used for microbial identification and determination of antimicrobial resistance.

IPC Classes  ?

  • C12Q 1/06 - Quantitative determination
  • C12Q 1/04 - Determining presence or kind of microorganismUse of selective media for testing antibiotics or bacteriocidesCompositions containing a chemical indicator therefor
  • C12Q 1/18 - Testing for antimicrobial activity of a material
  • G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing
  • G01N 33/569 - ImmunoassayBiospecific binding assayMaterials therefor for microorganisms, e.g. protozoa, bacteria, viruses
  • G01N 33/58 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving labelled substances
  • B82Y 20/00 - Nanooptics, e.g. quantum optics or photonic crystals
  • G01N 15/14 - Optical investigation techniques, e.g. flow cytometry
  • G01N 21/64 - FluorescencePhosphorescence

22.

FILTRATION ASSEMBLIES, CASSETTES, SYSTEMS, AND METHODS FOR FILTRATION AND CELL GROWTH

      
Document Number 03185278
Status Pending
Filing Date 2021-07-08
Open to Public Date 2022-01-13
Owner RAPID MICRO BIOSYSTEMS, INC. (USA)
Inventor
  • Rippeth, John
  • Wehebrink, Max
  • Tyldesley, Frank
  • Smith, Richard

Abstract

The present invention features filtration assemblies, cassettes, systems, and methods for filtering cells from a sample solution and then incubating the captured cells.

IPC Classes  ?

  • C12M 1/12 - Apparatus for enzymology or microbiology with sterilisation, filtration, or dialysis means
  • C12M 1/14 - Apparatus for enzymology or microbiology with means providing thin layers or with multi-level trays
  • C12M 1/16 - Apparatus for enzymology or microbiology containing, or adapted to contain, solid media
  • C12M 1/22 - Petri dishes
  • C12M 1/34 - Measuring or testing with condition measuring or sensing means, e.g. colony counters
  • C12M 3/04 - Tissue, human, animal or plant cell, or virus culture apparatus with means providing thin layers
  • C12Q 1/04 - Determining presence or kind of microorganismUse of selective media for testing antibiotics or bacteriocidesCompositions containing a chemical indicator therefor

23.

FILTRATION ASSEMBLIES, CASSETTES, SYSTEMS, AND METHODS FOR FILTRATION AND CELL GROWTH

      
Application Number US2021040935
Publication Number 2022/011169
Status In Force
Filing Date 2021-07-08
Publication Date 2022-01-13
Owner RAPID MICRO BIOSYSTEMS, INC. (USA)
Inventor
  • Rippeth, John
  • Wehebrink, Max
  • Tydesley, Frank
  • Smith, Richard

Abstract

The present invention features filtration assemblies, cassettes, systems, and methods for filtering cells from a sample solution and then incubating the captured cells.

IPC Classes  ?

  • C12M 1/12 - Apparatus for enzymology or microbiology with sterilisation, filtration, or dialysis means
  • C12M 1/14 - Apparatus for enzymology or microbiology with means providing thin layers or with multi-level trays
  • C12M 1/16 - Apparatus for enzymology or microbiology containing, or adapted to contain, solid media
  • C12M 1/22 - Petri dishes
  • C12M 1/34 - Measuring or testing with condition measuring or sensing means, e.g. colony counters
  • C12M 3/04 - Tissue, human, animal or plant cell, or virus culture apparatus with means providing thin layers
  • C12Q 1/04 - Determining presence or kind of microorganismUse of selective media for testing antibiotics or bacteriocidesCompositions containing a chemical indicator therefor

24.

Use of clean and dry gas for particle removal and assembly therefor

      
Application Number 17271443
Grant Number 12121842
Status In Force
Filing Date 2019-08-29
First Publication Date 2021-10-21
Grant Date 2024-10-22
Owner RAPID MICRO BIOSYSTEMS, INC. (USA)
Inventor
  • Higgins, Rich
  • Flaton, Ken

Abstract

The invention features particle removal assemblies and methods for removing dust and other debris from a sample container, e.g., to improve counting colonies of microorganisms (e.g., bacteria, fungi, or protists) present in environmental, pharmaceutical, biological, and other samples. An assembly of the invention includes components for particle removal, e.g., a filter, a dryer, a flow controller, and an outlet. The invention also provides methods of detecting samples after cleaning a sample container with clean and/or dry gas.

IPC Classes  ?

  • B01D 46/00 - Filters or filtering processes specially modified for separating dispersed particles from gases or vapours
  • B01D 53/26 - Drying gases or vapours

25.

ATTENUATED-BACKGROUND MICROBIOLOGICAL NUTRIENT MEDIA AND METHODS OF USING THE SAME

      
Document Number 03168092
Status Pending
Filing Date 2021-04-15
Open to Public Date 2021-10-21
Owner RAPID MICRO BIOSYSTEMS, INC. (USA)
Inventor
  • Barra, Jessica Tse
  • Rodriguez Santana, Juan Pablo
  • Grabar, Tammy Bohannon
  • Rippeth, John
  • Noble, Michael
  • Hughes, Gwilym

Abstract

The present invention features microbiological nutrient media capable of supporting growth of microorganisms. The medium includes a gelling agent and a dye and/or pigment that reduces background.

IPC Classes  ?

  • C12M 1/34 - Measuring or testing with condition measuring or sensing means, e.g. colony counters
  • C12Q 1/04 - Determining presence or kind of microorganismUse of selective media for testing antibiotics or bacteriocidesCompositions containing a chemical indicator therefor
  • G01N 21/64 - FluorescencePhosphorescence
  • G01N 33/58 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving labelled substances

26.

ATTENUATED-BACKGROUND MICROBIOLOGICAL NUTRIENT MEDIA AND METHODS OF USING THE SAME

      
Application Number US2021027483
Publication Number 2021/211845
Status In Force
Filing Date 2021-04-15
Publication Date 2021-10-21
Owner RAPID MICRO BIOSYSTEMS, INC. (USA)
Inventor
  • Barra, Jessica Tse
  • Rodriguez Santana, Juan Pablo
  • Grabar, Tammy Bohannon
  • Rippeth, John
  • Noble, Michael
  • Hughes, Gwilym

Abstract

The present invention features microbiological nutrient media capable of supporting growth of microorganisms. The medium includes a gelling agent and a dye and/or pigment that reduces background.

IPC Classes  ?

  • C12Q 1/04 - Determining presence or kind of microorganismUse of selective media for testing antibiotics or bacteriocidesCompositions containing a chemical indicator therefor
  • C12M 1/34 - Measuring or testing with condition measuring or sensing means, e.g. colony counters
  • G01N 15/14 - Optical investigation techniques, e.g. flow cytometry
  • G01N 21/64 - FluorescencePhosphorescence
  • G01N 33/58 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving labelled substances

27.

Microbiological growth media and methods of using the same

      
Application Number 17063108
Grant Number 11732237
Status In Force
Filing Date 2020-10-05
First Publication Date 2021-09-02
Grant Date 2023-08-22
Owner Rapid Micro Biosystems, Inc. (USA)
Inventor
  • Shara, Kate
  • Schwedock, Julie
  • Vogel, Sommer

Abstract

The present invention features general-purpose microbiological growth media capable of supporting growth of microorganisms on membranes. The media contain casein digest, soybean digest, animal tissue digest, yeast extract, dextrose, a phosphate buffer, hemin, and L-cystine. The invention features an all-purpose microbiological growth media that can support the growth of anaerobes, molds, injured spores, and general aerobic bacteria to a greater extent than other media.

IPC Classes  ?

  • C12N 1/20 - BacteriaCulture media therefor
  • C12N 1/14 - Fungi Culture media therefor
  • C12Q 1/04 - Determining presence or kind of microorganismUse of selective media for testing antibiotics or bacteriocidesCompositions containing a chemical indicator therefor
  • C12N 1/38 - Chemical stimulation of growth or activity by addition of chemical compounds which are not essential growth factorsStimulation of growth by removal of a chemical compound
  • C12N 1/16 - YeastsCulture media therefor

28.

Cassette for sterility testing

      
Application Number 17066630
Grant Number 11788046
Status In Force
Filing Date 2020-10-09
First Publication Date 2021-09-02
Grant Date 2023-10-17
Owner Rapid Micro Biosystems, Inc. (USA)
Inventor
  • Aviles, Robert C.
  • Michaud, Devin T.
  • Browne, Douglas J.

Abstract

The invention provides a device for growing cells—referred to as a cassette. The cell culturing device includes a housing that contains a lid having an optically clear window; a fluid distribution channel; a sample injection port fluidically connected to the fluid distribution channel; a base housing a porous media pad; and a media injection port fluidically connected to the media pad. The lid mates to the base to form a sterile seal; the fluid distribution channel is disposed over the media pad, which is viewable through the optical window; and sample fluid introduced into the fluid distribution channel is distributed evenly to the media pad, e.g., via a plurality of channels. The invention also provides kits that include cassettes of the invention and a tube set.

IPC Classes  ?

  • C12M 3/00 - Tissue, human, animal or plant cell, or virus culture apparatus
  • C12M 1/00 - Apparatus for enzymology or microbiology
  • C12M 1/22 - Petri dishes
  • C12M 1/12 - Apparatus for enzymology or microbiology with sterilisation, filtration, or dialysis means
  • C12M 1/26 - Inoculator or sampler
  • C12M 1/34 - Measuring or testing with condition measuring or sensing means, e.g. colony counters
  • C12Q 1/22 - Testing for sterility conditions

29.

Cell culturing device

      
Application Number 16564589
Grant Number 11643677
Status In Force
Filing Date 2019-09-09
First Publication Date 2020-07-02
Grant Date 2023-05-09
Owner RAPID MICRO BIOSYSTEMS, INC. (USA)
Inventor
  • Browne, Douglas J.
  • Karakozian, Sarkis
  • Chen, Xiaowei

Abstract

The invention features devices and kits for capturing and culturing microorganisms (e.g., bacteria, fungi, or protists) and methods of using the devices and kits to detect microorganisms in environmental and other samples. The device includes a nutrient media having a flat growth area on which microorganisms can grow. Samples are collected by contacting the device with any environmental sample, e.g., rolling device on a work surface or exposing device to air, or by filtering a sample through a membrane. Microorganisms deposited on the membrane derive nutrients from the underlying media and grow into colonies that can then be detected using methods known in the art. The detected colonies can be imaged digitally or with film.

IPC Classes  ?

  • C12M 1/22 - Petri dishes
  • C12M 1/00 - Apparatus for enzymology or microbiology
  • C12Q 1/04 - Determining presence or kind of microorganismUse of selective media for testing antibiotics or bacteriocidesCompositions containing a chemical indicator therefor

30.

USE OF CLEAN AND DRY GAS FOR PARTICLE REMOVAL AND ASSEMBLY THEREFOR

      
Application Number US2019048873
Publication Number 2020/047295
Status In Force
Filing Date 2019-08-29
Publication Date 2020-03-05
Owner RAPID MICRO BIOSYSTEMS, INC. (USA)
Inventor
  • Higgins, Rich
  • Flaton, Ken

Abstract

The invention features particle removal assemblies and methods for removing dust and other debris from a sample container, e.g., to improve counting colonies of microorganisms (e.g., bacteria, fungi, or protists) present in environmental, pharmaceutical, biological, and other samples. An assembly of the invention includes components for particle removal, e.g., a filter, a dryer, a flow controller, and an outlet. The invention also provides methods of detecting samples after cleaning a sample container with clean and/or dry gas.

IPC Classes  ?

  • G01N 1/22 - Devices for withdrawing samples in the gaseous state
  • B01D 53/00 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols
  • G01N 1/00 - SamplingPreparing specimens for investigation
  • G01N 1/02 - Devices for withdrawing samples

31.

USE OF CLEAN AND DRY GAS FOR PARTICLE REMOVAL AND ASSEMBLY THEREFOR

      
Document Number 03110851
Status Pending
Filing Date 2019-08-29
Open to Public Date 2020-03-05
Owner RAPID MICRO BIOSYSTEMS, INC. (USA)
Inventor
  • Higgins, Rich
  • Flaton, Ken

Abstract

The invention features particle removal assemblies and methods for removing dust and other debris from a sample container, e.g., to improve counting colonies of microorganisms (e.g., bacteria, fungi, or protists) present in environmental, pharmaceutical, biological, and other samples. An assembly of the invention includes components for particle removal, e.g., a filter, a dryer, a flow controller, and an outlet. The invention also provides methods of detecting samples after cleaning a sample container with clean and/or dry gas.

IPC Classes  ?

  • B01D 53/00 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols
  • G01N 1/00 - SamplingPreparing specimens for investigation
  • G01N 1/02 - Devices for withdrawing samples
  • G01N 1/22 - Devices for withdrawing samples in the gaseous state

32.

Cassette for sterility testing

      
Application Number 15687857
Grant Number 10801004
Status In Force
Filing Date 2017-08-28
First Publication Date 2018-03-15
Grant Date 2020-10-13
Owner Rapid Micro Biosystems, Inc. (USA)
Inventor
  • Aviles, Robert C.
  • Michaud, Devin T.
  • Browne, Douglas J.

Abstract

The invention provides a device for growing cells—referred to as a cassette. The cell culturing device includes a housing that contains a lid having an optically clear window; a fluid distribution channel; a sample injection port fluidically connected to the fluid distribution channel; a base housing a porous media pad; and a media injection port fluidically connected to the media pad. The lid mates to the base to form a sterile seal; the fluid distribution channel is disposed over the media pad, which is viewable through the optical window; and sample fluid introduced into the fluid distribution channel is distributed evenly to the media pad, e.g., via a plurality of channels. The invention also provides kits that include cassettes of the invention and a tube set.

IPC Classes  ?

  • C12M 3/00 - Tissue, human, animal or plant cell, or virus culture apparatus
  • C12M 1/00 - Apparatus for enzymology or microbiology
  • C12M 1/22 - Petri dishes
  • C12M 1/12 - Apparatus for enzymology or microbiology with sterilisation, filtration, or dialysis means
  • C12M 1/26 - Inoculator or sampler
  • C12M 1/34 - Measuring or testing with condition measuring or sensing means, e.g. colony counters
  • C12Q 1/22 - Testing for sterility conditions

33.

Microbiological growth media and methods of using the same

      
Application Number 15305789
Grant Number 10793823
Status In Force
Filing Date 2015-04-24
First Publication Date 2017-02-16
Grant Date 2020-10-06
Owner Rapid Micro Biosystems, Inc. (USA)
Inventor
  • Shara, Kate
  • Schwedock, Julie
  • Vogel, Sommer

Abstract

The present invention features general-purpose microbiological growth media capable of supporting growth of microorganisms on membranes. The media contain casein digest, soybean digest, animal tissue digest, yeast extract, dextrose, a phosphate buffer, hemin, and L-cystine. The invention features an all-purpose microbiological growth media that can support the growth of anaerobes, molds, injured spores, and general aerobic bacteria to a greater extent than other media.

IPC Classes  ?

  • C12N 1/20 - BacteriaCulture media therefor
  • C12N 1/14 - Fungi Culture media therefor
  • C12Q 1/04 - Determining presence or kind of microorganismUse of selective media for testing antibiotics or bacteriocidesCompositions containing a chemical indicator therefor
  • C12N 1/38 - Chemical stimulation of growth or activity by addition of chemical compounds which are not essential growth factorsStimulation of growth by removal of a chemical compound
  • C12N 1/16 - YeastsCulture media therefor

34.

MICROBIOLOGICAL GROWTH MEDIA AND METHODS OF USING THE SAME

      
Document Number 02946758
Status In Force
Filing Date 2015-04-24
Open to Public Date 2015-10-29
Grant Date 2022-08-30
Owner RAPID MICRO BIOSYSTEMS, INC. (USA)
Inventor
  • Shara, Kate
  • Schwedock, Julie
  • Vogel, Sommer

Abstract

The present invention features general-purpose microbiological growth media capable of supporting growth of microorganisms on membranes. The media contain casein digest, soybean digest, animal tissue digest, yeast extract, dextrose, a phosphate buffer, hemin, and L-cystine. The invention features an all-purpose microbiological growth media that can support the growth of anaerobes, molds, injured spores, and general aerobic bacteria to a greater extent than other media.

IPC Classes  ?

  • C12N 1/38 - Chemical stimulation of growth or activity by addition of chemical compounds which are not essential growth factorsStimulation of growth by removal of a chemical compound

35.

MICROBIOLOGICAL GROWTH MEDIA AND METHODS OF USING THE SAME

      
Application Number US2015027652
Publication Number 2015/164827
Status In Force
Filing Date 2015-04-24
Publication Date 2015-10-29
Owner RAPID MICRO BIOSYSTEMS, INC. (USA)
Inventor
  • Shara, Kate
  • Schwedock, Julie
  • Vogel, Sommer

Abstract

The present invention features general-purpose microbiological growth media capable of supporting growth of microorganisms on membranes. The media contain casein digest, soybean digest, animal tissue digest, yeast extract, dextrose, a phosphate buffer, hemin, and L-cystine. The invention features an all-purpose microbiological growth media that can support the growth of anaerobes, molds, injured spores, and general aerobic bacteria to a greater extent than other media.

IPC Classes  ?

  • C12N 1/38 - Chemical stimulation of growth or activity by addition of chemical compounds which are not essential growth factorsStimulation of growth by removal of a chemical compound

36.

Cell culturing device

      
Application Number 14394505
Grant Number 10407707
Status In Force
Filing Date 2013-04-16
First Publication Date 2015-03-12
Grant Date 2019-09-10
Owner Rapid Micro Biosystems, Inc. (USA)
Inventor
  • Browne, Douglas J.
  • Karakozian, Sarkis
  • Chen, Xiaowei

Abstract

The invention features devices and kits for capturing and culturing microorganisms (e.g., bacteria, fungi, or protists) and methods of using the devices and kits to detect microorganisms in environmental and other samples. The device includes a nutrient media having a flat growth area on which microorganisms can grow. Samples are collected by contacting the device with any environmental sample, e.g., rolling device on a work surface or exposing device to air, or by filtering a sample through a membrane. Microorganisms deposited on the membrane derive nutrients from the underlying media and grow into colonies that can then be detected using methods known in the art. The detected colonies can be imaged digitally or with film.

IPC Classes  ?

  • C12M 1/00 - Apparatus for enzymology or microbiology
  • C12M 1/22 - Petri dishes
  • C12Q 1/04 - Determining presence or kind of microorganismUse of selective media for testing antibiotics or bacteriocidesCompositions containing a chemical indicator therefor

37.

Cassette for sterility testing

      
Application Number 14355152
Grant Number 09745546
Status In Force
Filing Date 2012-11-07
First Publication Date 2014-11-20
Grant Date 2017-08-29
Owner Rapid Micro Biosystems, Inc. (USA)
Inventor
  • Aviles, Robert C.
  • Michaud, Devin T.
  • Browne, Douglas J.

Abstract

The invention provides a device for growing cells—referred to as a cassette. The cell culturing device includes a housing that contains a lid having an optically clear window; a fluid distribution channel; a sample injection port fluidically connected to the fluid distribution channel; a base housing a porous media pad; and a media injection port fluidically connected to the media pad. The lid mates to the base to form a sterile seal; the fluid distribution channel is disposed over the media pad, which is viewable through the optical window; and sample fluid introduced into the fluid distribution channel is distributed evenly to the media pad, e.g., via a plurality of channels. The invention also provides kits that include cassettes of the invention and a tube set.

IPC Classes  ?

  • C12M 3/00 - Tissue, human, animal or plant cell, or virus culture apparatus
  • C12Q 1/22 - Testing for sterility conditions
  • C12M 1/00 - Apparatus for enzymology or microbiology
  • C12M 1/22 - Petri dishes
  • C12M 1/12 - Apparatus for enzymology or microbiology with sterilisation, filtration, or dialysis means
  • C12M 1/26 - Inoculator or sampler
  • C12M 1/34 - Measuring or testing with condition measuring or sensing means, e.g. colony counters

38.

CELL CULTURING DEVICE

      
Document Number 03171698
Status Pending
Filing Date 2013-04-16
Open to Public Date 2013-10-24
Owner RAPID MICRO BIOSYSTEMS, INC. (USA)
Inventor
  • Browne, Douglas J.
  • Karakozian, Sarkis
  • Chen, Xiaowei

Abstract

The invention features devices and kits for capturing and culturing microorganisms (e.g., bacteria, fungi, or protists) and methods of using the devices and kits to detect microorganisms in environmental and other samples. The device includes a nutrient media having a flat growth area on which microorganisms can grow. Samples are collected by contacting the device with any environmental sample, e.g., rolling device on a work surface or exposing device to air, or by filtering a sample through a membrane. Microorganisms deposited on the membrane derive nutrients from the underlying media and grow into colonies that can then be detected using methods known in the art. The detected colonies can be imaged digitally or with film.

IPC Classes  ?

  • C12M 1/12 - Apparatus for enzymology or microbiology with sterilisation, filtration, or dialysis means
  • C12M 1/22 - Petri dishes

39.

CELL CULTURING DEVICE

      
Document Number 02870358
Status In Force
Filing Date 2013-04-16
Open to Public Date 2013-10-24
Grant Date 2022-11-22
Owner RAPID MICRO BIOSYSTEMS, INC. (USA)
Inventor
  • Browne, Douglas J.
  • Karakozian, Sarkis
  • Chen, Xiaowei

Abstract

The invention features devices and kits for capturing and culturing microorganisms (e.g., bacteria, fungi, or protists) and methods of using the devices and kits to detect microorganisms in environmental and other samples. The device includes a nutrient media having a flat growth area on which microorganisms can grow. Samples are collected by contacting the device with any environmental sample, e.g., rolling device on a work surface or exposing device to air, or by filtering a sample through a membrane. Microorganisms deposited on the membrane derive nutrients from the underlying media and grow into colonies that can then be detected using methods known in the art. The detected colonies can be imaged digitally or with film.

IPC Classes  ?

  • C12M 1/00 - Apparatus for enzymology or microbiology
  • C12M 1/12 - Apparatus for enzymology or microbiology with sterilisation, filtration, or dialysis means
  • C12M 1/14 - Apparatus for enzymology or microbiology with means providing thin layers or with multi-level trays
  • C12M 1/16 - Apparatus for enzymology or microbiology containing, or adapted to contain, solid media
  • C12M 1/22 - Petri dishes
  • C12Q 1/04 - Determining presence or kind of microorganismUse of selective media for testing antibiotics or bacteriocidesCompositions containing a chemical indicator therefor

40.

CELL CULTURING DEVICE

      
Application Number US2013036816
Publication Number 2013/158666
Status In Force
Filing Date 2013-04-16
Publication Date 2013-10-24
Owner RAPID MICRO BIOSYSTEMS, INC. (USA)
Inventor
  • Browne, Douglas, J.
  • Karakozian, Sarkis
  • Chen, Xiaowei

Abstract

The invention features devices and kits for capturing and culturing microorganisms (e.g., bacteria, fungi, or protists) and methods of using the devices and kits to detect microorganisms in environmental and other samples. The device includes a nutrient media having a flat growth area on which microorganisms can grow. Samples are collected by contacting the device with any environmental sample, e.g., rolling device on a work surface or exposing device to air, or by filtering a sample through a membrane. Microorganisms deposited on the membrane derive nutrients from the underlying media and grow into colonies that can then be detected using methods known in the art. The detected colonies can be imaged digitally or with film.

IPC Classes  ?

  • C12Q 1/04 - Determining presence or kind of microorganismUse of selective media for testing antibiotics or bacteriocidesCompositions containing a chemical indicator therefor
  • C12M 1/14 - Apparatus for enzymology or microbiology with means providing thin layers or with multi-level trays
  • C12M 1/00 - Apparatus for enzymology or microbiology

41.

A CELL CULTURING DEVICE ALLOWING FILTRATION THEREIN

      
Document Number 02854000
Status In Force
Filing Date 2012-11-07
Open to Public Date 2013-05-16
Grant Date 2023-01-24
Owner RAPID MICRO BIOSYSTEMS, INC. (USA)
Inventor
  • Aviles, Robert C.
  • Michaud, Devin T.
  • Browne, Douglas J.

Abstract

The invention provides a device for growing cells - referred to as a cassette. The cell culturing device includes a housing that contains a lid having an optically clear window; a fluid distribution channel; a sample injection port fluidically connected to the fluid distribution channel; a base housing a porous media pad; and a media injection port fluidically connected to the media pad. The lid mates to the base to form a sterile seal; the fluid distribution channel is disposed over the media pad, which is viewable through the optical window; and sample fluid introduced into the fluid distribution channel is distributed evenly to the media pad, e.g., via a plurality of channels. The invention also provides kits that include cassettes of the invention and a tube set.

IPC Classes  ?

  • C12M 1/00 - Apparatus for enzymology or microbiology
  • C12M 1/14 - Apparatus for enzymology or microbiology with means providing thin layers or with multi-level trays
  • C12M 1/34 - Measuring or testing with condition measuring or sensing means, e.g. colony counters
  • C12Q 1/02 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving viable microorganisms

42.

CASSETTE FOR STERILITY TESTING

      
Application Number US2012063904
Publication Number 2013/070730
Status In Force
Filing Date 2012-11-07
Publication Date 2013-05-16
Owner RAPID MICRO BIOSYSTEMS, INC. (USA)
Inventor
  • Aviles, Robert, C.
  • Michaud, Devin, T.
  • Browne, Douglas, J.

Abstract

The invention provides a device for growing cells - referred to as a cassette. The cell culturing device includes a housing that contains a lid having an optically clear window; a fluid distribution channel; a sample injection port fluidically connected to the fluid distribution channel; a base housing a porous media pad; and a media injection port fluidically connected to the media pad. The lid mates to the base to form a sterile seal; the fluid distribution channel is disposed over the media pad, which is viewable through the optical window; and sample fluid introduced into the fluid distribution channel is distributed evenly to the media pad, e.g., via a plurality of channels. The invention also provides kits that include cassettes of the invention and a tube set.

IPC Classes  ?

  • C12M 1/00 - Apparatus for enzymology or microbiology
  • C12M 3/00 - Tissue, human, animal or plant cell, or virus culture apparatus

43.

Cassette containing growth medium

      
Application Number 11527196
Grant Number 09057046
Status In Force
Filing Date 2006-09-26
First Publication Date 2007-09-13
Grant Date 2015-06-16
Owner RAPID MICRO BIOSYSTEMS, INC. (USA)
Inventor
  • Browne, Douglas
  • Straus, Don
  • Mace, Chad

Abstract

The invention features devices for capturing and culturing cells (e.g., microorganisms, cells containing microorganisms, or cells from eukaryotic cell cultures) and methods of using these devices. One device is a cassette containing growth media that may be employed in an automated rapid enumeration system. The cassette has, for example, been enhanced with features for controlling surface flatness, optical imaging, controlled dehydration of semi solid nutrient media, controlled air and particle exchange, and automated handling. Another device of the invention is a filtration funnel that may used to concentrate cells in a sample onto a membrane.

IPC Classes  ?

  • C12M 1/34 - Measuring or testing with condition measuring or sensing means, e.g. colony counters
  • C12M 1/22 - Petri dishes
  • C12M 1/00 - Apparatus for enzymology or microbiology
  • C12M 1/12 - Apparatus for enzymology or microbiology with sterilisation, filtration, or dialysis means

44.

CASSETTE CONTAINING GROWTH MEDIUM

      
Application Number US2006037410
Publication Number 2007/038478
Status In Force
Filing Date 2006-09-26
Publication Date 2007-04-05
Owner RAPID MICRO BIOSYSTEMS, INC (USA)
Inventor
  • Browne, Douglas
  • Straus, Don
  • Mace, Chad

Abstract

The invention features devices for capturing and culturing cells (e.g., microorganisms, cells containing microorganisms, or cells from eukaryotic cell cultures) and methods of using these devices. One device is a cassette containing growth media that may be employed in an automated rapid enumeration system. The cassette has, for example, been enhanced with features for controlling surface flatness, optical imaging, controlled dehydration of semi solid nutrient media, controlled air and particle exchange, and automated handling. Another device of the invention is a filtration funnel that may used to concentrate cells in a sample onto a membrane.

IPC Classes  ?

  • C12M 1/34 - Measuring or testing with condition measuring or sensing means, e.g. colony counters
  • C12M 1/22 - Petri dishes

45.

CASSETTE CONTAINING GROWTH MEDIUM

      
Document Number 02623408
Status In Force
Filing Date 2006-09-26
Open to Public Date 2007-04-05
Grant Date 2014-04-01
Owner RAPID MICRO BIOSYSTEMS, INC. (USA)
Inventor
  • Browne, Douglas
  • Straus, Don
  • Mace, Chad

Abstract

The invention features devices for capturing and culturing cells (e.g., microorganisms, cells containing microorganisms, or cells from eukaryotic cell cultures) and methods of using these devices. One device is a cassette containing growth media that may be employed in an automated rapid enumeration system. The cassette has, for example, been enhanced with features for controlling surface flatness, optical imaging, controlled dehydration of semi solid nutrient media, controlled air and particle exchange, and automated handling. Another device of the invention is a filtration funnel that may used to concentrate cells in a sample onto a membrane.

IPC Classes  ?

  • C12Q 1/04 - Determining presence or kind of microorganismUse of selective media for testing antibiotics or bacteriocidesCompositions containing a chemical indicator therefor