Porous hydrophilic composites for use in promoting bone growth are disclosed, along with methods for their preparation. The composites comprise a porous biodegradable polymer matrix, and nanosized calcium phosphate (CaP) homogeneously dispersed throughout the polymer matrix. The CaP has a specific surface area in the range of about 180 to about 380 m2/g.
A61L 27/46 - Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
Porous hydrophilic composites for use in promoting bone growth are disclosed, along with methods for their preparation. The composites comprise a porous biodegradable polymer matrix, and nanosized calcium phosphate (CaP) homogeneously dispersed throughout the polymer matrix. The CaP has a specific surface area in the range of about 180 to about 380 m2/g.
A61L 27/46 - Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
Porous hydrophilic composites for use in promoting bone growth are disclosed, along with methods for their preparation. The composites comprise a porous biodegradable polymer matrix, and nanosized calcium phosphate (CaP) homogeneously dispersed throughout the polymer matrix. The CaP has a specific surface area in the range of about 180 to about 380 m2/g.
A61L 27/46 - Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
Chemicals for use in industry and science; chemical compositions being coatings for medical or pharmaceutical implants Pharmaceutical implants comprising living tissue; biological implants, namely, a vital processed human or animal connective tissue; pharmaceutical and veterinary preparations for the treatment of bone diseases; implants comprising living tissue; surface coatings in the nature of drug delivery agents for pharmaceutical and biological implants that facilitate the delivery of a wide range of pharmaceuticals Artificial organs, dental prostheses and implants; medical implants consisting of artificial materials; biodegradable implants consisting of artificial materials; surgical, medical, dental and veterinary apparatus and instruments for use in oral surgery; surface coatings sold as an integral component of artificial organs, dental prostheses and implants; surface coatings sold as an integral component of medical implants comprising artificial material; dental implants
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
Chemicals used in industry in the form of coatings of biocompatible materials being components of implants, in particular of surgical, medical, orthopaedic and traumatological implants, dental implants and implants for mechanical stabilisation and fixing; Chemicals for use in industry and science; Chemical compositions being coatings for medical or pharmaceutical implants. Pharmaceutical implants; Biological implants; Pharmaceutical and veterinary preparations; Implants comprising living tissue; Surface coatings for pharmaceutical and biological implants. Artificial organs, prostheses and implants; Medical implants; Biodegradable implants; Surgical, medical, dental and veterinary apparatus and instruments; Surface coatings for artificial organs, prostheses and implants; Surface coatings for medical implants; Dental implants.
6.
Zirconium and titanium phosphate coatings for implants and other substrates
This invention is directed to coated substrates, wherein the coating comprises titanium phosphate and/or zirconium phosphate. In certain embodiments the substrate is an implant for use in vivo. The invention is also directed to methods for forming coatings comprising or consisting of titanium phosphate and/or zirconium phosphate on the surface of a substrate.
This invention is directed to coated substrates, wherein the coating comprises titanium phosphate and/or zirconium phosphate. In certain embodiments the substrate is an implant for use in vivo. The invention is also directed to methods for forming coatings comprising or consisting of titanium phosphate and/or zirconium phosphate on the surface of a substrate.
This invention is directed to coated substrates, wherein the coating comprises titanium phosphate and/or zirconium phosphate. In certain embodiments the substrate is an implant for use in vivo. The invention is also directed to methods for forming coatings comprising or consisting of titanium phosphate and/or zirconium phosphate on the surface of a substrate.
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
Chemicals for use in industry and science; Chemical compositions being coatings for medical or pharmaceutical implants [ Pharmaceutical implants comprising living tissue; Biological implants, namely, a vital processed human or animal connective tissue; Pharmaceutical and veterinary preparations for the treatment of bone diseases; Implants comprising living tissue; Surface coatings in the nature of drug delivery agents for pharmaceutical and biological implants that facilitate the delivery of a wide range of pharmaceuticals ] [ Artificial organs, dental prostheses and implants; Medical implants consisting of artificial materials; Biodegradable implants consisting of artificial materials; Surgical, medical, dental and veterinary apparatus and instruments for use in oral surgery; ] Surface coatings sold as an integral component of artificial organs, dental prostheses and implants; Surface coatings sold as an integral component of medical implants comprising artificial material; Dental implants
Composites and methods of producing a mouldable bone substitute are described. A scaffold for bone growth comprises nanocrystalline hydroxyapatite (HA), a bioresorbable plasticizer, and a biodegradable polymer. Plasticizers of the invention include oleic acid, tocopherol, eugenol, 1,2,3-triacetoxypropane, monoolein, and octyl-beta-D-glucopyranoside. Polymers of the invention include poly(caprolactone), poly(D,L-Lactic acid), and poly(glycolide-co lactide). Methods of regulating porosity, hardening speed, and shapeability are also described. Composites and methods are described using nanocrystalline HA produced with and without amino acids. The scaffold for bone growth described herein displays increased strength and shapeability.
A61L 27/46 - Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
A61L 27/58 - Materials at least partially resorbable by the body
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
Chemicals used in industry in the form of coatings of biocompatible materials being components of implants, in particular of surgical, medical, orthopaedic and traumatological implants, dental implants and implants for mechanical stabilisation and fixing; Chemicals for use in industry and science; Chemical compositions being coatings for medical or pharmaceutical implants. Pharmaceutical implants; Biological implants; Pharmaceutical and veterinary preparations; Implants comprising living tissue; Surface coatings for pharmaceutical and biological implants. Artificial organs, prostheses and implants; Medical implants; Biodegradable implants; Surgical, medical, dental and veterinary apparatus and instruments; Surface coatings for artificial organs, prostheses and implants; Surface coatings for medical implants; Dental implants.
Composites and methods of producing a moldable bone substitute are described. A scaffold for bone growth comprises nanocrystalline hydroxyapatite (HA), a bioresorbable plasticizer, and a biodegradable polymer. Plasticizers of the invention include oleic acid, tocopherol, eugenol, 1,2,3-triacetoxypropane, monoolein, and octyl-beta-D-glucopyranoside. Polymers of the invention include poly(caprolactone), poly(D,L-Lactic acid), and poly(glycolide-co lactide). Methods of regulating porosity, hardening speed, and shapeability are also described. Composites and methods are described using nanocrystalline HA produced with and without amino acids. The scaffold for bone growth described herein displays increased strength and shapeability.
A61F 2/00 - Filters implantable into blood vesselsProstheses, i.e. artificial substitutes or replacements for parts of the bodyAppliances for connecting them with the bodyDevices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
A61L 27/46 - Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
A61L 27/58 - Materials at least partially resorbable by the body
13.
Production of nanosized calcium phosphate particles as powder or coating via bifunctional precursors
Method of producing calcium phosphate particles, such as hydroxyapatite particles, in the form of a powder or coating on a solid support comprising an oxide surface or a polymer surface, such as titanium, titanium alloys, stainless steel, zirconia, glass and poly(styrene), poly(ether ether ketone) (PEEK), and poly(imide) is described. The method comprises I) providing a water solution containing calcium ions and water-soluble organic compound(s) comprising at least two functional groups, II) providing another water solution containing phosphate ions and water-soluble organic compound(s) comprising at least two functional groups, followed by III) mixing the solutions of (I) and (II) to create calcium phosphate particles coated with said water-soluble organic compounds. After washing and drying, the coated particles may be used as scaffolds or for production of a powder of calcium phosphate particles or crystals.
Composites and methods of producing a mouldable bone substitute are described. A scaffold for bone growth comprises nanocrystalline hydroxyapatite (HA), a bioresorbable plasticizer, and a biodegradable polymer. Plasticizers of the invention include oleic acid, tocopherol, eugenol, 1,2,3-triacetoxypropane, monoolein, and octyl-beta-D-glucopyranoside. Polymers of the invention include poly(caprolactone), poly(D,L-Lactic acid), and poly(glycolide-co lactide). Methods of regulating porosity, hardening speed, and shapeability are also described. Composites and methods are described using nanocrystalline HA produced with and without amino acids. The scaffold for bone growth described herein displays increased strength and shapeability.
A61L 27/12 - Phosphorus-containing materials, e.g. apatite
A61L 27/18 - Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
A61L 27/50 - Materials characterised by their function or physical properties
A61L 27/46 - Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
A61L 27/58 - Materials at least partially resorbable by the body
15.
Methods and systems of controlled coating of nanoparticles onto micro-rough implant surfaces and associated implants
The invention provides methods and systems that control the application of a material onto micro-rough implant surfaces. Thus, the present invention provides method of applying crystalline nanoparticles onto the surface of an implant to produce an implant with a crystalline nanoparticle layer on its surface, the method comprising: providing an implant substrate body; applying crystalline nanoparticles onto the surface of the implant; and rotating the implant, to produce an implant with a crystalline nanoparticle layer on its surface. This method of nanoparticle application is designed to promote the integration of implants, such as dental and orthopedic screws, into living tissue, and offers the ability to control the thickness and uniformity of the nanoparticle layer, in one or several layers, while simultaneously retaining the microroughness of the implant. Further provided are systems for applying crystalline nanoparticles onto the surface of an implant and implants having a crystalline nanoparticle layer on their surfaces.
B05D 1/02 - Processes for applying liquids or other fluent materials performed by spraying
B05D 1/40 - Distributing applied liquids or other fluent materials by members moving relatively to surface
B05D 3/04 - Pretreatment of surfaces to which liquids or other fluent materials are to be appliedAfter-treatment of applied coatings, e.g. intermediate treating of an applied coating preparatory to subsequent applications of liquids or other fluent materials by exposure to gases
The invention provides methods and systems that control the application of a material onto micro-rough implant surfaces. Thus, the present invention provides method of applying crystalline nanoparticles onto the surface of an implant to produce an implant with a crystalline nanoparticle layer on its surface, the method comprising: providing an implant substrate body; applying crystalline nanoparticles onto the surface of the implant; and rotating the implant, to produce an implant with a crystalline nanoparticle layer on its surface. This method of nanoparticle application is designed to promote the integration of implants, such as dental and orthopedic screws, into living tissue, and offers the ability to control the thickness and uniformity of the nanoparticle layer, in one or several layers, while simultaneously retaining the microroughness of the implant. Further provided are systems for applying crystalline nanoparticles onto the surface of an implant and implants having a crystalline nanoparticle layer on their surfaces.
Method of producing calcium phosphate particles, such as hydroxyapatite particles, in the form of a powder or coating on a solid support comprising an oxide surface or a polymer surface, such as titanium, titanium alloys, stainless steel, zirconia, glass and poly(styrene), poly(ether ether ketone) (PEEK), and poly(imide) is described. The method comprises I) providing a water solution containing calcium ions and water-soluble organic compound(s) comprising at least two functional groups, II) providing another water solution containing phosphate ions and water-soluble organic compound(s) comprising at least two functional groups, followed by III) mixing the solutions of (I) and (II) to create calcium phosphate particles coated with said water-soluble organic compounds. After washing and drying, the coated particles may be used as scaffolds or for production of a powder of calcium phosphate particles or crystals.
2/g, is described. The nano-sized crystalline calcium phosphate may be in the form of a powder or in the form of a coating on a surface. A method of producing a nano-sized crystalline calcium phosphate powder or coating is also described. The method comprises formation of a liquid crystalline phase in a water solution of calcium, phosphor and a surfactant, placing the phase in an ammonia atmosphere so that nano-sized crystals are formed, followed by either removal of the surfactant with a solvent and recovering the nano-sized crystals to obtain the powder, or diluting the ammonia-treated liquid crystalline phase with a hydrophobic organic solvent to create a microemulsion of the nano-sized crystals in water, dipping an oxide layer-coated surface of an object into the microemulsion, or alternatively saving the step of ammonia treatment of the liquid crystalline phase until after the dipping of the surface of an object into the microemulsion, followed by removal of the organic solvent and the surfactant from the surface to obtain the coating.
Synthetic nano-sized crystalline calcium phosphate, particularly hydroxyapatite, having a specific surface area in the range of 150 m2/g to 300 m2/g, is described. The nano-sized crystalline calcium phosphate may be in the form of a powder or in the form of a coating on a surface. A method of producing a nano-sized crystalline calcium phosphate powder or coating is also described. The method comprises formation of a liquid crystalline phase in a water solution of calcium, phosphor and a surfactant, placing the phase in an ammonia atmosphere so that nano-sized crystals are formed, followed by either removal of the surfactant with a solvent and recovering the nano-sized crystals to obtain the powder, or diluting the ammonia-treated liquid crystalline phase with a hydrophobic organic solvent to create a microemulsion of the nano-sized crystals in water, dipping an oxide layer-coated surface of an object into the microemulsion, or alternatively saving the step of ammonia treatment of the liquid crystalline phase until after the dipping of the surface of an object into the microemulsion, followed by removal of the organic solvent and the surfactant from the surface to obtain the coating.
