Politechnika Wroclawska

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IPC Class
A61P 13/04 - Drugs for disorders of the urinary system for urolithiasis 2
A61P 31/22 - Antivirals for DNA viruses for herpes viruses 2
B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers 2
C07K 5/10 - Tetrapeptides 2
H01J 37/34 - Gas-filled discharge tubes operating with cathodic sputtering 2
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Found results for  patents

1.

CENTRIFUGAL SEPARATOR IMPELLER AND METHOD OF SIEVING OF BULK MATERIALS IN THE CENTRIFUGAL SEPARATOR

      
Application Number PL2023050070
Publication Number 2025/048656
Status In Force
Filing Date 2023-08-28
Publication Date 2025-03-06
Owner
  • POLITECHNIKA WROCŁAWSKA (Poland)
  • FOUR POINT SP. Z O.O. (Poland)
Inventor
  • Moczko, Przemysław
  • Pietrusiak, Damian
  • Wróbel, Jakub
  • Fryckowski, Oskar
  • Wilgucki, Marek
  • Małachowski, Miłosz

Abstract

A centrifugal separator impeller designed for sieving bulk materials, granulates of various density and gradation, such as minerals, sand, grains, capsules, pellets or others, made of a perforated sheet (1) in the shape of a truncated cone, on whose inner surface flows the separated material, is characterized by the fact that the perforated sheet (1) on the inner side is equipped with a spiral channel (2) which forces a spiral path of movement, consistent with its geometry, of the separated material flowing along the inner surface of the side face of the sheet (1). A method of sieving bulk materials in a centrifugal separator in which the bulk material is sieved on a vibrating impeller, which has the form of a truncated cone perforated sheet and whose inner side is equipped with a spiral channel forcing a spiral path of movement, consistent with its geometry, of the separated material, which flows over the inner surface of the side face of the sheet, is characterized by the fact that the material is sieved in the impeller, whose natural frequencies, when coinciding with the frequency of the force vibrating the impeller, i.e. when in resonance, introduce local elastic deformations of the impeller,

IPC Classes  ?

  • B04B 3/00 - Centrifuges with rotary bowls in which solid particles or bodies become separated by centrifugal force and simultaneously sifting or filtering
  • B04B 11/02 - Continuous feeding or dischargingControl arrangements therefor
  • B04B 3/06 - Centrifuges with rotary bowls in which solid particles or bodies become separated by centrifugal force and simultaneously sifting or filtering discharging solid particles by vibrating the bowl

2.

A METHOD FOR THE MANUFACTURING OF A MULTI-COMPONENT TARGET FOR MAGNETRON SPUTTERING, A SET OF TOOLS FOR THE MANUFACTURING OF A MULTI-COMPONENT TARGET FOR MAGNETRON SPUTTERING, AND THE SPUTTERING TARGET WITH ITS APPLICATION FOR THE DEPOSITION OF PROTECTIVE COATING

      
Application Number PL2023000046
Publication Number 2024/263043
Status In Force
Filing Date 2023-08-31
Publication Date 2024-12-26
Owner
  • SIEĆ BADAWCZA ŁUKASIEWICZ - POZNAŃSKI INSTYTUT TECHNOLOGICZNY (Poland)
  • INSTYTUT PODSTAWOWYCH PROBLEMÓW TECHNIKI POLSKIEJ AKADEMII NAUK (Poland)
  • SIEĆ BADAWCZA ŁUKASIEWICZ - INSTYTUT TECHNOLOGII EKSPLOATACJI (Poland)
  • POLITECHNIKA WROCŁAWSKA (Poland)
  • POLITECHNIKA WARSZAWSKA (Poland)
  • ALBATROS ALUMINIUM SP. Z O.O. (Poland)
  • SANHA POLSKA SP. Z O.O. (Poland)
Inventor
  • Garbiec, Dariusz
  • Wiśniewska, Maria
  • Mościcki,tomasz
  • Smolik, Jerzy
  • Polak, Sławomir

Abstract

A method for manufacturing a multi-component target for magnetron sputtering is that the technological process is conducted using powder materials, the components of which are selected from powders: tungsten (W), in an amount in the range of 69.9 to 84.6 wt%, advantageously 78.4 wt%, boron (B) in an amount in the range of 13.5 to 24.3 wt%, advantageously 15.2 wt% and an intermediate metal, advantageously titanium (Ti), in an amount in the range of 1.7 to 6.4 wt%, advantageously 6,4 wt%, which are placed in a high-energy ball mill in a shielding gas atmosphere, advantageously argon, and then the obtained mixture of powders (5) is compacted in a tool set constructed according to the invention, placed in the vacuum chamber of a spark plasma sintering (SPS) device, where the compacting process is conducted in a sintering temperature from 1600 °C to 1800 °C, advantageously 1650 °C, with a heating rate from 10°C/min to 400 °C/min, over a time of 2 min to 30 min, under a pressure of 30 MPa to 50 MPa, advantageously 32 MPa, in a vacuum of more than 5 x10-2mbar, advantageously 5 x10-2 mbar, to obtain a multi-component circular magnetron target with a diameter within a range of from 80 mm to 100 mm, advantageously 100 mm. A tool set for the manufacturing of multi-component target placed in a vacuum chamber of the spark plasma sintering (SPS) device, characterised in that graphite sintering tools containing cylindrical punches: lower (1) and upper (2) form with a circular die (3) a feeding chamber with an internal diameter in the range of 80 to 100 mm, advantageously 100 mm for placing a mixture of powders (5). Moreover, the entire tool set has in a horizontal plane, centric in respect to its vertical axis, sequentially placed elements. Proper selection of materials for individual elements of the tool set in the form of graphite and CFRC composite and updated design of the tool set, as well as the use of complete thermal insulation with the use of graphite felt enabled significant reduction of energy demand by the spark plasma sintering device. Multi-component magnetron target, characterized in that it has the form of a circular target with a diameter in the range of 80-100 mm, advantageously 100 mm and contains tungsten (W) in an amount of 69.9 to 84.6 wt%, advantageously 78.4 wt% and boron (B) in an amount from 13.5 to 24.3 wt%, advantageously 15.2 wt% and an intermediate metal, advantageously titanium (Ti), in an amount in the range from 1.7 to 6.4 wt%, advantageously 6.4 wt%.

IPC Classes  ?

  • C23C 14/34 - Sputtering
  • H01J 37/34 - Gas-filled discharge tubes operating with cathodic sputtering
  • B22F 3/105 - Sintering only by using electric current, laser radiation or plasma
  • C04B 35/58 - Shaped ceramic products characterised by their compositionCeramic compositionsProcessing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on non-oxides based on borides, nitrides or silicides
  • C22C 1/04 - Making non-ferrous alloys by powder metallurgy
  • C22C 29/14 - Alloys based on carbides, oxides, borides, nitrides or silicides, e.g. cermets, or other metal compounds, e. g. oxynitrides, sulfides based on borides
  • C04B 35/626 - Preparing or treating the powders individually or as batches

3.

POROUS AND SOLID ELASTOMERIC BIOACTIVE POLYMER-CERAMIC COMPOSITES FOR BONE DEFECT FILLING AND BONE TISSUE REGENERATION

      
Application Number PL2023050048
Publication Number 2024/167424
Status In Force
Filing Date 2023-06-30
Publication Date 2024-08-15
Owner
  • POLITECHNIKA WROCLAWSKA (Poland)
  • UNIWERSYTET LODZKI (Poland)
  • POLITECHNIKA KRAKOWSKA (Poland)
  • SIEC BADAWCZA LUKASIEWICZ- INSTYTUT CERAMIKI I MATERIALOW BUDOWLANYCH (Poland)
Inventor
  • Gazinska, Malgorzata
  • Zielinska, Sonia
  • Korbut, Aleksandra
  • Szustkiewicz, Konrad
  • Piszko, Pawel
  • Kryszak, Bartlomiej
  • Sieja, Katarzyna
  • Trochimczuk, Andrzej
  • Rudnicka, Karolina
  • Plocinski, Przemyslaw
  • Szwed-Grorgiou, Aleksandra
  • Krupa, Agnieszka
  • Wlodarczyk, Marcin
  • Sobczak-Kupiec, Agnieszka
  • Slota, Dagmara
  • Plorkiewicz, Wioletta
  • Tomala, Agnieszka
  • Pietak, Karina
  • Tyliszczak, Bożena
  • Biernat, Monika
  • Szterner, Piotr
  • Kurzyk, Agata
  • Antosik, Agnieszka
  • Pagacz, Joanna
  • Tymowicz-Grzyb, Paulina

Abstract

The invention regards polymer-ceramic biocomposites in two embodiments based on poly(glycerol sebacate) (PGS) containing calcium phosphate particles, produced in the form of flexible porous materials for use as implant material for filling bone defects. Also an object of the invention is a method for producing biocomposites in the form of flexible porous and solid materials.

IPC Classes  ?

  • A61L 27/18 - Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
  • A61L 27/46 - Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
  • A61L 27/56 - Porous or cellular materials
  • C04B 26/10 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds

4.

COMPOUNDS FOR THE DETECTION AND INHIBITION OF COAGULATION PROTEASES

      
Application Number GB2023050659
Publication Number 2023/175356
Status In Force
Filing Date 2023-03-17
Publication Date 2023-09-21
Owner
  • POLITECHNIKA WROCLAWSKA (Poland)
  • CAMBRIDGE ENTERPRISE LIMITED (United Kingdom)
Inventor
  • Drag, Marcin
  • Kasperkiewicz-Wasilewska, Paulina
  • Modrzycka, Sylwia
  • Huntington, James Andrew

Abstract

112341x1234xx are defined herein. The present invention also relates to compositions comprising the compounds of formula (I) or formula (X) defined herein, to processes for synthesising these compounds and to their use for the treatment and/or detection of diseases and conditions in which coagulation proteases, in particular APC, flla, fXa, and fXla, are implicated.

IPC Classes  ?

  • A61P 7/00 - Drugs for disorders of the blood or the extracellular fluid
  • A61P 7/04 - AntihaemorrhagicsProcoagulantsHaemostatic agentsAntifibrinolytic agents
  • C07K 5/103 - Tetrapeptides the side chain of the first amino acid being acyclic, e.g. Gly, Ala
  • C07K 5/107 - Tetrapeptides the side chain of the first amino acid containing carbocyclic rings, e.g. Phe, Tyr
  • C07K 5/11 - Tetrapeptides the side chain of the first amino acid containing more amino groups than carboxyl groups, or derivatives thereof, e.g. Lys, Arg
  • C07K 5/117 - Tetrapeptides the first amino acid being heterocyclic, e.g. Pro, His, Trp
  • C07K 5/10 - Tetrapeptides

5.

METHOD OF DEGRADING ANTIBIOTICS FROM AQUEOUS SOLUTIONS BY USING COLD ATMOSPHERIC PRESSURE PLASMA GENERATED IN A FLOWING PLASMA BRUSH AND A PLASMA BRUSH INTENDED FOR THIS METHOD

      
Application Number PL2022050027
Publication Number 2023/140747
Status In Force
Filing Date 2022-05-06
Publication Date 2023-07-27
Owner
  • POLITECHNIKA WROCŁAWSKA (Poland)
  • UNIWERSYTET GDAŃSKI (Poland)
Inventor
  • Dzimitrowicz, Anna
  • Motyka-Pomagruk, Agata
  • Caban, Magda
  • Babińska, Weronika
  • Terefinko, Dominik
  • Śledź, Wojciech
  • Jamróz, Piotr
  • Cyganowski, Piotr
  • Łojkowska, Ewa
  • Stepnowski, Piotr
  • Pohl, Paweł

Abstract

The subject of the invention is a method of degrading antibiotics in aqueous solutions by using cold atmospheric pressure plasma - pm-rf-APGD or DBD, characterized in that by the following steps: a) the analyzed aqueous antibiotic solution or a mixture of antibiotics selected from the group of fluoroquinolones and/or tetracyclines and/or trimethoprims and/or chloramphenicols and/or β-lactams, are introduced into the flow plasma brush by a connection (8) attached to the chamber (7), b) the discharge gas is introduced through a wire (1) equipped with a gas valve (2), c) the discharge gas is further transported in a pipe (1) separated into at least 3 parts in the root (3), d) then a current is applied to the metal tubes (5) with the use of a current generator, leading as a result to generation of cold atmospheric plasma (6) in the form of 4 or 5 cones of pm-rf-APGD cold plasma or DBD, respectively. e) after treatment of the aqueous solution of antibiotics or the mixture of antibiotics with the pm-rf-APGD- or DBD-type cold plasma (6), respectively, the solution is collected in a chamber (7), delivered outside through a stub pipe (10) and subjected to further analysis. The subject of the invention is also the flow plasma brush characterized in that it contains a root (3) into whose upper part a gas valve (2) and a discharge gas supply conduit (1), divided in the middle part of the root (3) into at least 3 parts, are connected, the lower part of the root (3) is equipped with metal tubes (5) from which, as a result of applying a current from a current generator, cold atmospheric pressure plasma (6) is generated, the generated plasma (6) is in the form of 4 or 5 pm-rf-APGD- or DBD-type cones, metal pipes (5) are attached to the root (3) with rubber hoses (4) and link the chamber (7) with a connection (8) and a stub pipe (10), where the metal pipes (5) are braided with copper wires (9).

IPC Classes  ?

  • C02F 1/46 - Treatment of water, waste water, or sewage by electrochemical methods
  • H05H 1/24 - Generating plasma
  • C02F 101/30 - Organic compounds
  • C02F 103/34 - Nature of the water, waste water, sewage or sludge to be treated from the chemical industry not provided for in groups

6.

A METHOD FOR THE PRODUCTION OF FUNCTIONAL HUMIC AND FULVIC PRODUCTS FROM NATURAL ORGANIC RAW MATERIALS

      
Application Number PL2020050056
Publication Number 2022/025779
Status In Force
Filing Date 2020-08-03
Publication Date 2022-02-03
Owner POLITECHNIKA WROCŁAWSKA (Poland)
Inventor
  • Hoffmann, Józef
  • Huculak-Mączka, Marta
  • Nieweś, Dominik
  • Hoffmann, Krystyna
  • Klem-Marciniak, Ewelina
  • Zieliński, Jakub
  • Kaniewski, Maciej
  • Braun-Giwerska, Magdalena
  • Biegun, Marcin

Abstract

3433433'23'23433 acid with the concentration of up to 50 wt.%, and the products in the form of humic and fulvic acids are separated, wherein the activation and/or extraction process is aided with ultrasounds.

IPC Classes  ?

  • C05F 11/02 - Other organic fertilisers from peat, brown coal, or similar vegetable deposits

7.

COMPOUNDS FOR THE TREATMENT OR DIAGNOSIS OF COVID-19

      
Application Number PL2021050037
Publication Number 2021/246886
Status In Force
Filing Date 2021-06-04
Publication Date 2021-12-09
Owner POLITECHNIKA WROCŁAWSKA (Poland)
Inventor
  • Drąg, Marcin
  • Rut, Wioletta

Abstract

Disclosed are compounds for use in the treatment, prophylaxis or diagnosis of COVID-19.

IPC Classes  ?

  • A61K 31/16 - Amides, e.g. hydroxamic acids
  • A61K 31/165 - Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
  • A61K 31/4025 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
  • A61K 31/404 - Indoles, e.g. pindolol
  • A61K 31/4188 - 1,3-Diazoles condensed with heterocyclic ring systems, e.g. biotin, sorbinil
  • A61K 31/426 - 1,3-Thiazoles
  • A61K 38/00 - Medicinal preparations containing peptides
  • A61P 31/14 - Antivirals for RNA viruses

8.

MAGNETIC MICROFLUIDIC DEVICE FOR HIGH-THROUGHPUT SCREENING

      
Application Number PL2019050075
Publication Number 2020/226519
Status In Force
Filing Date 2019-12-06
Publication Date 2020-11-12
Owner
  • POLITECHNIKA WROCŁAWSKA (Poland)
  • UNIWERSYTET MEDYCZNY IM. PIASTÓW ŚLĄSKICH WE WROCŁAWIU (Poland)
Inventor
  • Szafran, Roman
  • Gąsiorowski, Kazimierz
  • Wiatrak, Benita

Abstract

The subject of the invention is a magnetic microfluidic device for high-throughput screening, consisting of a lid (4), a base (6), tank covers (3) and a functional chip layer (5), while the chip lid contains supply tanks (8) and a millimeter graduation (7) and the functional chip layer contains culture chambers (9), characterized by the fact that it consists of a microfluidic chip (1) transparent to visible light and UV and equipped with at least three linear culture chambers (9), each with a connection to the supply vessels at the ends (8), a flexible base (6) and a magnetic microfield generator (1) consisting of a platform (10) containing the chip socket (17), spacers (12), a generator base assembly consisting of the top (13) and bottom (15), containing a magnet socket (20), a permanent magnet (14) and a number of ferromagnetic pins (11), where the arrangement of culture chambers (9) in the microfluidic chip (2) and the arrangement of ferromagnetic pins (11) of the magnetic microfield generator (1) is mutually correlated in such a way that the ferromagnetic pins (11) in the platform (10) run parallel from the surface of the culture chambers (9) to the upper surface of the permanent magnet (14).

IPC Classes  ?

  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
  • C12M 3/06 - Tissue, human, animal or plant cell, or virus culture apparatus with filtration, ultrafiltration, inverse osmosis or dialysis means
  • C12M 1/42 - Apparatus for the treatment of microorganisms or enzymes with electrical or wave energy, e.g. magnetism, sonic wave
  • B03C 1/033 - Component partsAuxiliary operations characterised by the magnetic circuit

9.

USE OF CHIRAL (1R, 2R)-DIAMINOCYCLOHEXANE DERIVATIVE WITH TADDOL SUBSTITUENT

      
Application Number PL2020050033
Publication Number 2020/222665
Status In Force
Filing Date 2020-04-24
Publication Date 2020-11-05
Owner
  • POLITECHNIKA WROCŁAWSKA (Poland)
  • UNIWERSYTET JAGIELLOŃSKI (Poland)
Inventor
  • Wojaczyńska, Elżbieta
  • Iwanejko, Jakub
  • Olszewski, Tomasz
  • Grzywa, Renata
  • Sieńczyk, Marcin
  • Pyrć, Krzysztof
  • Pachota, Magdalena

Abstract

The subject of the invention is the use of chiral (1R, 2R)-diaminocyclohexane derivative with a taddol substituent for the treatment and prevention of herpes type 1, by inhibiting the replication of HSV 1 virus.

IPC Classes  ?

  • A61K 31/498 - Pyrazines or piperazines ortho- or peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
  • A61P 31/22 - Antivirals for DNA viruses for herpes viruses

10.

USE OF A CHIRAL 2-AZABICYCLOALKANE DERIVATIVE WITH DANSYL SUBSTITUENT AS VP24 PROTEASE INHIBITOR TO INHIBIT THE REPLICATION OF HSV-1 VIRUS

      
Application Number PL2020050034
Publication Number 2020/222666
Status In Force
Filing Date 2020-04-24
Publication Date 2020-11-05
Owner
  • POLITECHNIKA WROCŁAWSKA (Poland)
  • UNIWERSYTET JAGIELLOŃSKI (Poland)
Inventor
  • Wojaczyńska, Elżbieta
  • Iwan, Dominika
  • Grzywa, Renata
  • Sieńczyk, Marcin
  • Pyrć, Krzysztof
  • Pachota, Magdalena

Abstract

The subject of the invention is the use of a chiral 2-azabicycloalkane derivative with dansyl substituent as VP24 protease inhibitor to inhibit the replication of HSV-1 virus. The invention concerns chiral 2-azabicycloalkane derivative with dansyl substituent, formula 1, for use as a drug especially for the treatment and prevention of herpes type 1 by inhibiting the replication of HSV-1 virus.

IPC Classes  ?

  • A61K 31/55 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
  • A61P 31/22 - Antivirals for DNA viruses for herpes viruses

11.

METHOD OF MANUFACTURING A MULTILAYER MICROFLUIDIC DEVICE FOR DYNAMIC TISSUE CULTURE

      
Application Number PL2018000010
Publication Number 2018/143831
Status In Force
Filing Date 2018-01-26
Publication Date 2018-08-09
Owner
  • POLITECHNIKA WROCŁAWSKA (Poland)
  • UNIWERSYTET MEDYCZNY W LODZI (Poland)
Inventor
  • Szafran, Roman
  • Pawłowska, Agnieszka
  • Fichna, Jakub
  • Lewandowska, Urszula

Abstract

The method of manufacturing a multilayer microfluidic device for the conduct of tissue culture under dynamic conditions is presented, which consists of at least six layers (these are: bottom and lid, adhesive layer, at least one auxiliary glass layer, at least one elastomeric functional layer and at least one hydrogel layer). The method is characterized by the fact that in the first stage, on the basis of pre-designed maps of each layer of the device, its elements (vascular and connecting channels and microchannels, inspection, positioning and through holes, culture chambers, partitions and tanks) are produced. For this purpose, elastomeric layers are prepared in such a way that the medium is coated with a layer of elastomer and fixed. Then the focused laser beam does the engraving and cuts the structures. The auxiliary glass layers, the adhesive layer and the bottom and lid of the microdevices are engraved and the structure are cut by means of a focused laser beam operating on material sheets. In the second stage, non-adhesive auxiliary glass layers and elastomeric functional layers are combined into sets. Each set consists of one glass layer and one elastomeric layer on a carrier which forms the temporary basis of the set. In the third stage, the previously prepared liquid hydrogel is introduced through inspection holes into the culture chambers of the sets where it is fixed and then disconnected from the temporary base of the unit. In this way, in the exposed hydrogel layer, vascular microchannels are engraved, whereas connecting channels are engraved in partitions, by means of a focused laser beam. In the fourth stage, without the use of glue, one or more sets are joined together or to the bottom or to the lid by means of an adhesive layer. In the fifth stage, the microsystem is combined with liquid supply and outlet hoses using an adhesive. In the sixth stage, the microsystem is cleaned and washed. In the seventh stage, suspension of cells of any type is introduced into the microsystem, once or several times, at intervals allowing their immobilization on the surface of microchannels. In the eighth stage, cell culture is carried out under flow conditions in order to form a network of capillary vessels within the artificial tissue.

IPC Classes  ?

  • C12M 3/00 - Tissue, human, animal or plant cell, or virus culture apparatus
  • B81B 1/00 - Devices without movable or flexible elements, e.g. microcapillary devices
  • B81B 7/00 - Microstructural systems
  • B32B 3/10 - Layered products comprising a layer with external or internal discontinuities or unevennesses, or a layer of non-planar shapeLayered products comprising a layer having particular features of form characterised by a discontinuous layer, i.e. apertured or formed of separate pieces of material
  • B32B 33/00 - Layered products characterised by particular properties or particular surface features, e.g. particular surface coatingsLayered products designed for particular purposes not covered by another single class

12.

MICROFLUIDIC DEVICE FOR CELL CULTURE IN GRADIENT OF BIOACTIVE SUBSTANCE

      
Application Number PL2017000122
Publication Number 2018/106132
Status In Force
Filing Date 2017-12-08
Publication Date 2018-06-14
Owner
  • POLITECHNIKA WROCŁAWSKA (Poland)
  • UNIWERSYTET MEDYCZNY IM. PIASTÓW ŚLĄSKICH (Poland)
Inventor
  • Szafran, Roman
  • Gąsiorowski, Kazimierz
  • Gębczak, Katarzyna
  • Wiatrak, Benita

Abstract

A multilayer microfluidic device for cell culture in the gradient of a bioactive substance characterised by three layers and two protective cups (3) of tanks, the top layer being a cover (6), which contains tanks of fluids feeding the culture chambers (1), reference points (4) and a millimetre graduation (5); in the middle functional layer (7), made of adhesive film, there is a set of channels serving as culture and indicator chambers (2) with semi-circular ends (8), at least one of which is intended for cell culture in concentration gradient of the active substance (culture chamber), one for cell culture without an active agent (blind test) and one to develop a concentration profile of the indicator substance (indicator chamber); and the bottom layer is the base (9).

IPC Classes  ?

  • C12M 3/00 - Tissue, human, animal or plant cell, or virus culture apparatus
  • C12M 1/00 - Apparatus for enzymology or microbiology
  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
  • B81B 7/00 - Microstructural systems

13.

METHOD OF FILLING AND EMPTYING THE WORKING CHAMBER OF THE HYDRAULIC CYLINDER AND A HYDRAULIC CYLINDER TOGETHER WITH A CONTROL SYSTEM AND A HYDRAULIC CYLINDER FOR PERFORMING THE METHOD ACCORDING TO THE INVENTION

      
Application Number PL2016000146
Publication Number 2017/099616
Status In Force
Filing Date 2016-12-08
Publication Date 2017-06-15
Owner POLITECHNIKA WROCŁAWSKA (Poland)
Inventor
  • Siwulski, Tomasz
  • Warzyńska, Urszula

Abstract

A method of filling and emptying the working chamber of the hydraulic cylinder intended for universal use in industrial practice, in particular in heavy industry and intended in particular, for use in the systems operating at high temperatures or under high workload, distinctive by the fact that hydraulic fluid is fed to each working chamber (6, 7) of the hydraulic cylinder through a valve (12a,12b) via one supply hydraulic line (8, 9), and it is discharged via a second valve (12c, 12d), through a discharge hydraulic line (10,11). A hydraulic cylinder together with a control system built from a cylinder (1), in which a plunger (23) or piston (4) interconnected with a piston rod (3) is mounted, distinctive by the fact that two hydraulic lines, each with a valve (12a, 12b, 12c, 12d), are led to each working chamber (6, 7) of the cylinder, wherein one of them is a supply hydraulic line (8, 9) and the second one is a discharge hydraulic line (10, 11). A hydraulic cylinder made of a cylinder (1) in which a plunger (23) or a piston (4) interconnected with a piston rod (3) is mounted, distinctive by the fact that each of the working chambers (6, 7) of the cylinder s equipped with two connection pipes (18, 19, 20, 21), the first of which is intended for connecting the supply hydraulic line and the other one for connecting the discharge hydraulic line.

IPC Classes  ?

  • F15B 15/08 - Fluid-actuated devices for displacing a member from one position to anotherGearing associated therewith characterised by the construction of the motor unit
  • F15B 15/14 - Fluid-actuated devices for displacing a member from one position to anotherGearing associated therewith characterised by the construction of the motor unit of the straight-cylinder type

14.

METHOD AND DEVICE FOR DETERMINING THE QUALITY OF MOTOR-CAR FUEL

      
Application Number PL2015000120
Publication Number 2017/018893
Status In Force
Filing Date 2015-07-24
Publication Date 2017-02-02
Owner POLITECHNIKA WROCŁAWSKA (Poland)
Inventor
  • Teterycz, Helena
  • Wiśniewski, Kamil
  • Klubiński, Grzegorz
  • Suchorska-Woźniak, Patrycja
  • Rac, Olga
  • Fiedot, Marta

Abstract

Method of determining the quality of motor-car fuel in accordance with the invention is characterized by the fact that with experimental methods the impedance calibration curve is determined, after which the impedance as a function of the frequency of resonator element (2) submerged in the fuel tested and stimulated by electric signal from generator (1), then from the measured impedance characteristics as a function of frequency, the field of circle on the complex plane of Nyquist plot ('Z, Z") is determined characteristic for the composition of the fuel mixture tested on the basis of which the fuel composition is determined. The device is equipped with generator (1) connected to the resonator (2), which by vector voltmeter ammeter (3) and vector ammeter (4) is connected to arithmetic system (5) connected to micro-controller (12).

IPC Classes  ?

  • G01N 27/02 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance
  • G01R 27/02 - Measuring real or complex resistance, reactance, impedance, or other two-pole characteristics derived therefrom, e.g. time constant
  • G01R 27/08 - Measuring resistance by measuring both voltage and current
  • G01R 27/22 - Measuring resistance of fluids
  • G01N 33/28 - Oils

15.

PHENOL GLYCOSIDES AND THEIR USE IN THE TREATMENT OF UROLITHIASIS

      
Application Number PL2015050028
Publication Number 2017/007346
Status In Force
Filing Date 2015-07-06
Publication Date 2017-01-12
Owner POLITECHNIKA WROCŁAWSKA (Poland)
Inventor
  • Gancarz, Roman
  • Kubas, Karolina

Abstract

The present invention relates to novel derivatives of polyphenol glycoside or polyalcohols of formula (1), wherein R1, R2, R3 is selected from the group consisting of H, OH, C(O)R4, C(0) OR4, 0 (Gly H3)n, wherein n = 0 1, 2, 3, and R4 is selected from the group consisting of H, alkyl, and Gly is a mono- or disaccharide residue. The present invention also relates to novel derivatives of glycoside polyphenols or polyalcohols, as pharmaceutical composition comprising a novel polyphenol glycoside or polyalcohols and the use of novel polyphenol glycoside or polyalcohols for the treatment of urolithiasis.

IPC Classes  ?

  • C07H 15/203 - Monocyclic carbocyclic rings other than cyclohexane ringsBicyclic carbocyclic ring systems
  • A61K 31/7034 - Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
  • A61P 13/04 - Drugs for disorders of the urinary system for urolithiasis

16.

A METHOD OF PRODUCING A PLANT PREPARATION FROM A CONE HOPS, KNOTWEED AND CRANBERRY, PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH COMPOUNDS AND THEIR USAGE

      
Application Number PL2015050029
Publication Number 2017/007347
Status In Force
Filing Date 2015-07-08
Publication Date 2017-01-12
Owner POLITECHNIKA WROCŁAWSKA (Poland)
Inventor
  • Gancarz, Roman
  • Klepacz, Ewa

Abstract

The invention relates to a method of producing a plant extracts with cone hops, knotweed and American cranberry, characterized in that the cones of hops (Humulus lupulus L.), St. John's knotweed (Polygonum aviculare L.) and fruit cranberry (Vaccinium macrocarpon L.) is extracted with carbon dioxide in a supercritical state, and then the solvent is evaporated. The present invention also relates to the preparation of plant extracts as pharmaceutical composition comprising the formulation of the plant, and the use of a preparation plant for the treatment of kidney stones and the use of extraction with carbon dioxide in supercritical conditions for preparing the plant formulations of the cone hops, knotweed and cranberry.

IPC Classes  ?

  • A61K 36/185 - Magnoliopsida (dicotyledons)
  • A61K 36/45 - Ericaceae or Vacciniaceae (Heath or Blueberry family), e.g. blueberry, cranberry or bilberry
  • A61K 36/704 - Polygonum, e.g. knotweed
  • A61P 13/04 - Drugs for disorders of the urinary system for urolithiasis

17.

ANTIVIRAL PHARMACEUTICAL PREPARATION FOR USE IN TREATMENT OF HEPATITIS C

      
Application Number IB2015054670
Publication Number 2016/051289
Status In Force
Filing Date 2015-06-22
Publication Date 2016-04-07
Owner POLITECHNIKA WROCŁAWSKA (Poland)
Inventor
  • Skoreński, Marcin
  • Oleksyszyn, Józef
  • Sieńczyk, Marcin

Abstract

The object of the present invention are novel peptide derivatives of diaryl esters of 1 - aminoalkylphosphonic acids and their use as inhibitors of NS3/4A protease expressed by human HCV virus in prophylaxis and therapy of viral hepatitis type C (VHC). The use of inhibitors with irreversible mechanism of inhibition in the treatment of HCV creates the possibility of effective improvement of the therapy inter alia by reducing the time of drug administration and limiting dosing to one drug.

IPC Classes  ?

18.

DEVICE AND METHOD FOR CONTROLLING THE CALIBRATION OF THERMOCHROMIC LIQUID-CRYSTAL MATRICES

      
Application Number IB2014064445
Publication Number 2016/038425
Status In Force
Filing Date 2014-09-11
Publication Date 2016-03-17
Owner
  • BRASTER SA (Poland)
  • POLITECHNIKA WROCŁAWSKA (Poland)
Inventor
  • Reiner, Jacek
  • Mrzygłód, Mariusz
  • Tryba, Dariusz
  • Trzyna, Marcin
  • Cieszyński, Wojciech
  • Jaremek, Henryk
  • Zmywaczyk, Janusz

Abstract

The subject of the invention is a device for controlling the calibration of thermochromic liquid- crystal matrices characterized in that it comprises a heating table (2) with stabilized thermally active means (3) and (4) placed at the ends and temperature sensors (5), stretching-pressing means (9), a lighting (9), a detector (7) and a screen (11). The invention also relates to a method of controlling the TLC matrix using the above-mentioned device and the using the said device for testing thermal-chromatic calibration of the thermochromic liquid-crystal matrices.

IPC Classes  ?

  • G01K 11/16 - Measuring temperature based on physical or chemical changes not covered by group , , , or using changes in colour, translucency or reflectance of organic materials
  • G01K 15/00 - Testing or calibrating of thermometers

19.

METHOD FOR PREPARING OF THIN AND ULTRATHIN POLYMER FILMS ON SOLID SUBSTRATES

      
Application Number PL2015000110
Publication Number 2016/003301
Status In Force
Filing Date 2015-07-02
Publication Date 2016-01-07
Owner POLITECHNIKA WROCŁAWSKA (Poland)
Inventor
  • Janus, Krzysztof
  • Sworakowski, Juliusz
  • Saniszewski, Adam
  • Bielecka, Urszula

Abstract

The invention relates to method for preparing thin and ultrathin polymer films on solid substrates, in particular: glass, quartz, ITO coated glass, mica, comprising deposition of a layer of solution or suspension of polymer, followed by fabrication of solid layer by using a laser light forming a line with uniform light intensity, which is moving in a direction perpendicular to its axis.

IPC Classes  ?

  • B05D 3/06 - Pretreatment of surfaces to which liquids or other fluent materials are to be appliedAfter-treatment of applied coatings, e.g. intermediate treating of an applied coating preparatory to subsequent applications of liquids or other fluent materials by exposure to radiation
  • B23K 26/073 - Shaping the laser spot
  • C03C 17/32 - Surface treatment of glass, e.g. of devitrified glass, not in the form of fibres or filaments, by coating with organic material with synthetic or natural resins

20.

COATING FOR ABSORBING ENERGY, ESPECIALLY THE ENERGY OF ELECTROMAGNETIC AND MECHANICAL WAVES, AND ITS USE

      
Application Number IB2014065663
Publication Number 2015/063681
Status In Force
Filing Date 2014-10-28
Publication Date 2015-05-07
Owner
  • UNIWERSYTET WROCLAWSKI (Poland)
  • POLITECHNIKA WROCLAWSKA (Poland)
Inventor
  • Kaczmar, Jacek
  • Kołodziej, Hubert
  • Mayer, Paulina
  • Sowa, Andrzej
  • Strzelecki, Stanisław
  • Vogt, Andrzej

Abstract

The invention relates to a coating for absorbing energy, especially the energy of electromagnetic and mechanical waves, which is applicable in electrical and electronic devices, and inside buildings, characterised in that it has a substrate (1) in the form of metal sheet or polymer plate, on which at least one absorber layer (2) is applied, wherein the absorber layer (2) is in the form of loose or compressed powder grains, pellets, beads or gel, on which a polymer layer (3) is placed. The object of the invention is also the use of the coating for absorbing energy.

IPC Classes  ?

  • H05K 9/00 - Screening of apparatus or components against electric or magnetic fields

21.

TEXTILE PRODUCT FOR ATTENUATION OF ELECTROMAGNETIC FIELD AND THE DEVICES FOR MANUFACTURING THE TEXTILE PRODUCT ATTENUATING ELECTROMAGNETIC FIELD

      
Application Number PL2013000006
Publication Number 2013/115660
Status In Force
Filing Date 2013-01-25
Publication Date 2013-08-08
Owner
  • INSTYTUT WŁÓKIENNICTWA (Poland)
  • POLITECHNIKA WROCŁAWSKA (Poland)
Inventor
  • Koprowska, Joanna
  • Kusiakiewicz, Janusz
  • Szwugier, Arkadiusz
  • Jegier, Grzegorz
  • Ziaja, Jan

Abstract

The subject of this invention is a textile product attenuating electromagnetic field and a device for manufacturing textile materials attenuating electromagnetic field by coating a textile material with coatings deposited by magnetron sputtering method, whereby the textile materials are intended for applications such as electromagnetic shields, used especially in hospitals, office blocks, dwelling houses and laboratories, and which may be used for manufacturing of wallpaper, curtains, blinds and roller blinds. The textile product has at least one layer (L1, L2, L3, L4) of metal and/or at least one layer (L1, L2, L3, L4) of metal oxide with the thickness below few micrometers, formula I, deposited on a substrate (S) alternately, where the number of the (L1, L2, L3, L4) layers depends on the coefficient of shielding efficiency of electromagnetic field by the textile product. Inside a vacuum chamber, above the conveying device fixed to the base (10) there is a three-layer anode in a shape of a part of cylindrical surface, mounted with insulators (6) on the base (10) fixed to the chamber housing. The anode, on the side of the target (1 1), has a sliding layer (5) and under this layer, a layer of supporting structure (4) while on the bottom, there is a temperature stabilizer (3) to which a cooling system made of a set of pipes (2) transporting the cooling medium is mounted. Above the three-layer anode there is a magnetron sputtering device (1) equipped with a rectangular target (11), connected to a supplier (27) which is coupled through a control system (26) with a computer unit (25). The control system (26) is connected through a valve controller (28) with a control valve (29), an instrument for measuring the length of a coated fabric (30), and simultaneously, through a engine velocity governor (31) with a motor (32) driving a two-way drive (9) of the conveying device.

IPC Classes  ?

  • D06M 11/83 - Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with inorganic substances or complexes thereofSuch treatment combined with mechanical treatment, e.g. mercerising with metalsTreating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with inorganic substances or complexes thereofSuch treatment combined with mechanical treatment, e.g. mercerising with metal-generating compounds, e.g. metal carbonylsReduction of metal compounds on textiles
  • C23C 14/00 - Coating by vacuum evaporation, by sputtering or by ion implantation of the coating forming material
  • H01J 37/34 - Gas-filled discharge tubes operating with cathodic sputtering
  • D06M 11/44 - Oxides or hydroxides of elements of Groups 2 or 12 of the Periodic TableZincatesCadmates
  • D06M 11/46 - Oxides or hydroxides of elements of Groups 4 or 14 of the Periodic TableTitanatesZirconatesStannatesPlumbates

22.

SPRAYING METHOD AND SPRAY HEAD COMPRISING A LAVAL NOZZLE AND AN ANNULAR INDUCTION ELECTRODE

      
Application Number PL2011000099
Publication Number 2013/028084
Status In Force
Filing Date 2011-09-30
Publication Date 2013-02-28
Owner
  • PRZEMYSŁOWY INSTYTUT MASZYN ROLNICZYCH (Poland)
  • POLITECHNIKA WROCLAWSKA (Poland)
  • TELESTO SP. Z O.O. (Poland)
Inventor
  • Sobkowiak, Boleslaw
  • Kacprzyk, Ryszard
  • Zylka, Paweł
  • Pawłowski, Tadeusz
  • Lada, Zygmunt

Abstract

Method for carrying out agrotechnical spraying with chemical substances, characterized in that pneumatic atomization is performed using a convergent - divergent nozzle (3) to which gas is supplied under pressure within the range from 1 to 5 x 105 Pa, wherein in the divergent part of the nozzle (3) in the widest point it reaches speed a few times faster than the speed of sound, so that gas accelerated to ultrasonic speed disintegrates technological liquid flowing out from a capillary tube into drops of size from a few to a dozen micrometers, which are charged in an electrical field with a direct current voltage from a few hundred to 3 kilovolts, an annular electrode (7) is being supplied with voltage ue no more that 70 percent of voltage up, at which electrical discharge begins to occur in the space between the annual electrode (7) and the capillary tube (4) for technological liquid.

IPC Classes  ?

  • B05B 5/03 - Discharge apparatus, e.g. electrostatic spray guns characterised by the use of gas
  • B05B 5/043 - Discharge apparatus, e.g. electrostatic spray guns using induction-charging

23.

ELECTRON DETECTION UNIT AND A SCANNING ELECTRON MICROSCOPE

      
Application Number PL2009000073
Publication Number 2010/008307
Status In Force
Filing Date 2009-07-13
Publication Date 2010-01-21
Owner POLITECHNIKA WROCLAWSKA (Poland)
Inventor Slowko, Witold

Abstract

The subject of the invention is a electron detector unit and a scanning electron microscope equipped with this unit, destined particularly for detection of low energy secondary electrons at the pressures range from values lower than 0.1 Pa to values exceeding 1000 Pa in the sample chamber. Electron detector unit, destined particularly for a scanning electron microscope with variable gas pressure P1 in the sample chamber contains the intermediate chamber (13 ) of a differential vacuum system where the differential pressure P2 is maintained. The intermediate chamber (13 ) is arranged under the objective lens ( 9 ) of the scanning electron microscope and sealed with a gasket ( 30 ). In a hole made in a side part of the intermediate chamber (13 ), a main light guide ( 11 ) in the form of a bar made of poly methyl methacrylate (PMMA) is fastened hermetically. Inside the intermediate chamber (13 ), a screening sleeve ( 4 ) in a shape of a cut cone is secured with use of insulating insertions. In the neighborhood of the lower hole of the screening tube ( 4 ), an anode ( 5 ) in the form of a metal ring covered with a thin layer of scintillator ( 5 ) a is arranged and electrically separated. In the lower part of the intermediate chamber ( 13 ) is a hole screened by a lower throttling aperture ( 5 ) of small diameter being sealed with an insulating interlay ( 29 ). The screening tube ( 4 ) and anode ( 5 ) and the lower throttling aperture (15 ) are placed coaxially with the electron optical axis EOA along which the electron beam EB passes. On the lower throttling aperture ( 15 ), a repelling aperture ( 31 ) made of metal foil well reflecting light is fastened with use of an insulating interlay ( 29 ). Diameter of the opening of the repelling aperture ( 31 ) is larger than that of the lower throttling aperture (15 ) and its symmetry axis is shifted aside the electron optical axis EOA toward the main light guide (11 ).

IPC Classes  ?

  • H01J 37/244 - DetectorsAssociated components or circuits therefor
  • H01J 37/18 - Vacuum locks
  • H01J 37/28 - Electron or ion microscopesElectron- or ion-diffraction tubes with scanning beams

24.

METHOD AND SYSTEM TO DETERMINE COMPENSATORY PARAMETERS OF INTRACRANIAL SPACE DURING THE INFUSION TEST

      
Application Number PL2008000001
Publication Number 2009/002196
Status In Force
Filing Date 2008-01-03
Publication Date 2008-12-31
Owner POLITECHNIKA WROCLAWSKA (Poland)
Inventor
  • Juniewicz, Henryk
  • Cieslicki, Krzysztof
  • Kasprowicz, Magdalena

Abstract

The method is that the infusion is stopped with temporary values of intracranial pressure while in the increasing phase, and when the intracranial pressure values are higher than those determined by the inflexion point tp, and also after the inflexion point value is exceeded, and in addition the inflexion point tp on a curve created by temporary values of the intracranial pressure in the increasing phase, is described by the formula: where: tp is the time at which the inflexion point occurs on the intracranial pressure curve in the increasing phase; whereas the intracranial pressure after the infusion has been stopped in the descending phase, is expressed by the following formula: where: ICP02 is a reference pressure of the cerebrospinal fluid in the descending phase, E2 is an intracranial elastance coefficient in the descending phase, RCSF2 is a resistance of the cerebrospinal fluid reabsorption in the descending phase, and then, from temporary values of the intracranial fluid pressure ICP(t) in the descending phase, the reference pressure of the cerebrospinal fluid ICP02 in the descending phase is determined, as is also E2/RCSF2 the quotient of the intracranial elastance coefficient E2 divided by the resistance of the cerebrospinal fluid reabsorption RCSF2 in the descending phase. The system consists of the intracranial pressure sensor (3) through a pressure transducer (4) that converts pressure into an analog signal, and through an analog-to- digital converter (5), is connected to a digital signal recording and processing system (6), and the infusion pump (2) is also connected to the digital signal recording and processing system (6).

IPC Classes  ?

  • A61B 5/03 - Measuring fluid pressure within the body other than blood pressure, e.g. cerebral pressure

25.

Secondary electron detector unit for a scanning electron microscope

      
Application Number 11248431
Grant Number 07425708
Status In Force
Filing Date 2005-10-13
First Publication Date 2006-02-09
Grant Date 2008-09-16
Owner Politechnika Wrolawska (Poland)
Inventor Slowko, Witold

Abstract

The secondary electron detector unit for a scanning electron microscope is mounted in a head body (1). In the lower part of the head body (1), a lower throttling aperture (2) is placed. Above the lower throttling aperture (2), the microporous plate (3) is sealed in the head body (1) by a gasket (5) and fastened with the use of the frame plate (6) which has an opening that exposes the active input area (7) placed asymmetrically with respect to the axis of the scanning electron beam (WE). Above the microporous plate (3), the scintillator (11) and the light pipe (12) are fixed at the side of the head body (1).

IPC Classes  ?

  • G01K 1/08 - Protective devices, e.g. casings