A dry-granulation method for producing a tablet comprising (a) pharmaceutical active ingredient in an amount 50-90% w/w and (b) one or more excipients in an amount 10-50% w/w including at least a binder which comprises (i) preparing granules from a powder comprising a binder, a pharmaceutically active ingredient and optionally one or more other excipients or pharmaceutical active ingredients by a process characterized in that a compaction force is applied to the powder to produce a compacted mass comprising a mixture of fine particles and granules and separating and removing fine particles and/or small granules from the granules by entraining the fine particles and/or small granules in a gas stream in which the compacted mass flows, wherein the direction of the flow of the gas stream has a component which is contrary to that of the direction of flow of the compacted mass, and collecting the accepted granules (ii) blending the accepted granules with other components of the tablet in granular or fine powder form wherein in step (ii) at least one other component of the tablet formulation is in granular form and is prepared from a powder comprising said other component by a process characterized in that a compaction force is applied to the powder to produce a compacted mass comprising a mixture of fine particles and granules and separating and removing fine particles and/or small granules from the granules by entraining the fine particles and/or small granules in a gas stream in which the compacted mass flows, wherein the direction of the flow of the gas stream has a component which is contrary to that of the direction of flow of the compacted mass; and (iii) compressing the resultant blend to form a tablet; with the proviso that the tablet does not comprise (a) paracetamol, maize starch and microcrystalline cellulose in a ratio of 60:20:20 w/w, (b) acebutolol HCl and starch in a ratio of 90:10 w/w, (c) sodium valproate, hypromellose and maize starch in a ratio of 90:5:5 w/w, (d) ketoprofen and maize starch in a ratio of 50:50 w/w or (e) metformin HCl, microcrystalline cellulose and maize starch in a ratio of 80:14:6 w/w.
B01J 2/22 - Processes or devices for granulating materials, in generalRendering particulate materials free flowing in general, e.g. making them hydrophobic by pressing in moulds or between rollers
B07B 1/24 - Revolving drums with fixed or moving interior agitators
B07B 4/02 - Separating solids from solids by subjecting their mixture to gas currents while the mixtures fall
B07B 4/08 - Separating solids from solids by subjecting their mixture to gas currents while the mixtures are supported by sieves, screens, or like mechanical elements
B07B 7/04 - Selective separation of solid materials carried by, or dispersed in, gas currents by impingement against baffle separators
B07B 7/06 - Selective separation of solid materials carried by, or dispersed in, gas currents by impingement against sieves
B07B 7/086 - Selective separation of solid materials carried by, or dispersed in, gas currents using centrifugal force generated by the winding course of the gas stream
A61K 31/167 - Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen atom of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
A61K 31/192 - Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
B29B 9/12 - Making granules characterised by structure or composition
A61J 3/10 - Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of compressed tablets
The invention provides, inter alia, a method for producing granules from a powder, characterized in that compaction force is applied to the powder to produce a compacted mass comprising a mixture of fine particles and granules and separating and removing fine particles and/or small granules from the other granules by entraining the fine particles and/or small granules in a gas stream. Also provided are apparatus for use in the process and tablets formed by compression of the resultant granules.
B01J 2/22 - Processes or devices for granulating materials, in generalRendering particulate materials free flowing in general, e.g. making them hydrophobic by pressing in moulds or between rollers
B07B 1/24 - Revolving drums with fixed or moving interior agitators
B07B 4/02 - Separating solids from solids by subjecting their mixture to gas currents while the mixtures fall
B07B 4/08 - Separating solids from solids by subjecting their mixture to gas currents while the mixtures are supported by sieves, screens, or like mechanical elements
B07B 7/04 - Selective separation of solid materials carried by, or dispersed in, gas currents by impingement against baffle separators
B07B 7/06 - Selective separation of solid materials carried by, or dispersed in, gas currents by impingement against sieves
B07B 7/086 - Selective separation of solid materials carried by, or dispersed in, gas currents using centrifugal force generated by the winding course of the gas stream
A61K 31/167 - Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen atom of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
A61K 31/192 - Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
B29B 9/12 - Making granules characterised by structure or composition
A61J 3/10 - Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of compressed tablets
The invention provides, inter alia, a method for producing granules from a powder, characterized in that compaction force is applied to the powder to produce a compacted mass comprising a mixture of fine particles and granules and separating and removing fine particles and/or small granules from the other granules by entraining the fine particles and/or small granules in a gas stream. Also provided are apparatus for use in the process and tablets formed by compression of the resultant granules.
A61K 9/22 - Sustained or differential release type
B07B 7/086 - Selective separation of solid materials carried by, or dispersed in, gas currents using centrifugal force generated by the winding course of the gas stream
B01J 2/22 - Processes or devices for granulating materials, in generalRendering particulate materials free flowing in general, e.g. making them hydrophobic by pressing in moulds or between rollers
B07B 1/24 - Revolving drums with fixed or moving interior agitators
B07B 4/02 - Separating solids from solids by subjecting their mixture to gas currents while the mixtures fall
B07B 4/08 - Separating solids from solids by subjecting their mixture to gas currents while the mixtures are supported by sieves, screens, or like mechanical elements
B07B 7/04 - Selective separation of solid materials carried by, or dispersed in, gas currents by impingement against baffle separators
B07B 7/06 - Selective separation of solid materials carried by, or dispersed in, gas currents by impingement against sieves
A61J 3/10 - Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of compressed tablets
The invention provides, inter alia, a method for producing granules from a powder, characterized in that a low compaction force is applied to the powder to produce a compacted mass comprising a mixture of fine particles and granules and separating fine particles from the granules by entraining the fine particles in a gas stream. Also provided are apparatus for use in the process and tablets formed by compression of the resultant granules.
B01J 2/22 - Processes or devices for granulating materials, in generalRendering particulate materials free flowing in general, e.g. making them hydrophobic by pressing in moulds or between rollers
B03C 7/06 - Separators with cylindrical material carriers
A61J 3/10 - Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of compressed tablets
The invention provides, inter alia, a method for producing granules from a powder, characterized in that compaction force is applied to the powder to produce a compacted mass comprising a mixture of fine particles and granules and separating and removing fine particles and/or small granules from the other granules by entraining the fine particles and/or small granules in a gas stream. Also provided are apparatus for use in the process and tablets formed by compression of the resultant granules.
The invention provides, inter alia, a method for producing granules from a powder, characterized in that compaction force is applied to the powder to produce a compacted mass comprising a mixture of fine particles and granules and separating and removing fine particles and/or small granules from the other granules by entraining the fine particles and/or small granules in a gas stream. Also provided are apparatus for use in the process and tablets formed by compression of the resultant granules.
B01J 2/22 - Processes or devices for granulating materials, in generalRendering particulate materials free flowing in general, e.g. making them hydrophobic by pressing in moulds or between rollers
B07B 1/24 - Revolving drums with fixed or moving interior agitators
B07B 7/06 - Selective separation of solid materials carried by, or dispersed in, gas currents by impingement against sieves
A61J 3/06 - Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of pills, lozenges or dragees
A61J 3/10 - Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of compressed tablets
B07B 4/02 - Separating solids from solids by subjecting their mixture to gas currents while the mixtures fall
B07B 4/08 - Separating solids from solids by subjecting their mixture to gas currents while the mixtures are supported by sieves, screens, or like mechanical elements
B07B 7/04 - Selective separation of solid materials carried by, or dispersed in, gas currents by impingement against baffle separators
The invention provides, inter alia, a method for producing a tablet comprising (a) a first active ingredient in an amount 50-90% w/w and (b) one or more excipients including at least a binder in an amount 10-50% w/w.
A61J 3/10 - Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of compressed tablets
B01J 2/22 - Processes or devices for granulating materials, in generalRendering particulate materials free flowing in general, e.g. making them hydrophobic by pressing in moulds or between rollers
B07B 7/00 - Selective separation of solid materials carried by, or dispersed in, gas currents
8.
PROCESS FOR PREPARING A VERY HIGH DRUG LOAD TABLET
The invention provides, inter alia, a method for producing a tablet comprising (a) active ingredient in an amount 90.01 -99.99% w/w and (b) one or more excipients in an amount 0.01 -9.99%.
The invention provides, inter alia, a method for producing a tablet comprising (a) at least one dry granulated excipient and (b) at least one active pharmaceutical ingredient. Also a method for producing granular mass comprising one or more excipients is disclosed.
The invention provides, inter alia, a method for producing a tablet comprising (a) a first active ingredient in an amount 0.01 -19.99% w/w and (b) one or more excipients including at least a binder in an amount 80.01 -99.99% w/w.
A61J 3/10 - Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of compressed tablets
B01J 2/22 - Processes or devices for granulating materials, in generalRendering particulate materials free flowing in general, e.g. making them hydrophobic by pressing in moulds or between rollers
11.
PROCESS FOR PREPARING A TABLET COMPRISING METFORMIN
The invention provides, inter alia, a method for producing a tablet comprising (a) metformin and a second active ingredient in a combined amount of 50-90% w/w and (b) one or more excipients including at least a binder in an amount 10-50% w/w.
The invention provides a method for producing granules from a powder comprising at least 60 % w/w of ibuprofen sodium dihydrate, characterized in that compaction force is applied to the powder to produce a compacted mass comprising a mixture of fine particles and granules and separating and removing fine particles and/or small granules from the granules by entraining the fine particles and/or small granules in a gas stream. A dry-granulated mass and a tablet comprising ibuprofen sodium dehydrate and a process for preparing a tablet are provided.
B01J 2/00 - Processes or devices for granulating materials, in generalRendering particulate materials free flowing in general, e.g. making them hydrophobic
A61K 31/192 - Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
B07B 7/10 - Selective separation of solid materials carried by, or dispersed in, gas currents using centrifugal force having air recirculating within the apparatus
The invention provides, inter alia, a method for producing granules from a powder, characterized in that a low compaction force is applied to the powder to produce a compacted mass comprising a mixture of fine particles and granules and separating fine particles from the granules by entraining the fine particles in a gas stream. Also provided are apparatus for use in the process and tablets formed by compression of the resultant granules.
B01J 2/22 - Processes or devices for granulating materials, in generalRendering particulate materials free flowing in general, e.g. making them hydrophobic by pressing in moulds or between rollers
B07B 1/24 - Revolving drums with fixed or moving interior agitators
B07B 7/06 - Selective separation of solid materials carried by, or dispersed in, gas currents by impingement against sieves
A61J 3/06 - Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of pills, lozenges or dragees
A61J 3/10 - Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of compressed tablets
The invention provides, inter alia, a method for producing granules from a powder, characterized in that a low compaction force is applied to the powder to produce a compacted mass comprising a mixture of fine particles and granules and separating fine particles from the granules by entraining the fine particles in a gas stream. Also provided are apparatus for use in the process and tablets formed by compression of the resultant granules.
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